30 completed, 12 unknown, 9 recruiting, 3 active not recruiting. 40 Not applicable, 4 Phase 1, 2 Phase 2, 2 Phase 3, 2 Phase 4.
Follow Age-Related Cognitive Decline: new trials by email Literature Review of Age-Related Cognitive Decline trials Research Report on Age-Related Cognitive Decline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| EMBRACE - From Vulnerable to Empowered: Implementation and Evaluation of a Multicomponent Program to Tackling Age-related Decline EMBRACE Intervention - Age-Related Cognitive Decline | Not applicable | Not yet recruiting | University Fernando Pessoa | 120 | 2026-06-01 | 2026-06-05 |
| Feasibility and Adherence to a Technology-assisted Home-based Strength Training Program in Adults With Type 2 Diabetes Mellitus and Mild Cognitive Impairment Progressive Exercise Program (12 Weeks) - Type2diabetes, Mild Cognitive Impairment | Not applicable | Recruiting | The University of Texas Medical Branch, Galveston | 20 | 2026-04-14 | 2026-05-11 |
| Acute Effects of THC in Older Adult Delta-9-THC Low Dose, Placebo, Delta-9-THC Medium Dose - Age-related Cognitive Decline | Phase 1 | Recruiting | Yale University | 60 | 2025-06-06 | 2026-10-09 |
| A Graphene Far-infrared Intervention Study of Cognitive Status in Older Adults Graphene-Based Far-Infrared Intervention, Thermal-Effects Control - Subjective Cognitive Decrease (SCD), Age-Related Cognitive Decline | Not applicable | Completed | Institute of Psychology, Chinese Academy of Sciences | 168 | 2025-03-01 | 2026-11-03 |
| Multidomain Interventions for Elderly Individuals in Residential Structures Physical activity, Cognitive stimulation, Nutritional Intervention - Aging, Age-Related Cognitive Decline | Not applicable | Completed | Istituto di Neuroscienze Consiglio Nazionale delle Ricerche | 90 | 2025-02-03 | 2026-04-08 |
| Cardiac-Control Affecting Learning Through Mindfulness (CALM) Daily practice - Age-related Cognitive Decline, Alzheimer Disease | Not applicable | Recruiting | University of Southern California | 240 | 2025-01-14 | 2026-05-13 |
| Cognitive Function and EEG Brain Network Remodeling Among Users of Hearing Aids With ARHL hearing aids - Age-related Hearing Loss, Age-related Cognitive Decline | Active not recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 60 | 2024-12-01 | 2025-03-25 | |
| ItaliaN Study With Tailored Multidomain Interventions to Prevent Functional and Cognitive Decline in Community-dwelling Older Adults Nutritional intervention, Physical exercise, Cognitive training - Age-related Cognitive Decline | Not applicable | Recruiting | University of Milano Bicocca | 1340 | 2024-07-16 | 2025-07-29 |
| Multi-organ Responses to CHronic Physical Activity and INactivity Decreased Physical Activity, Increased Physical activity - Sedentary Behavior, Metabolic Syndrome | Not applicable | Recruiting | University of Nottingham | 40 | 2024-03-12 | 2025-12-04 |
| Effectiveness Of Computer-Based Cognitive Training in Age-Related Cognitive Decline Aerobic Exercise and Computerized Cognitive Training, Conventional Exercises and Brain health lectures - Age-related Cognitive Decline | Not applicable | Completed | University of Jazan | 60 | 2024-01-15 | 2025-07-29 |
| Brain Enhancement Training Towards Elders Resilience to Aging, Phase IIB Computerized Plasticity-Based Adaptive Cognitive Training - Age-related Cognitive Decline | Not applicable | Completed | Posit Science Corporation | 135 | 2023-12-14 | 2026-02-19 |
| Interest of Two Digital Devices for the Diagnosis of Neurocognitive Disorders in Elderly People With Cognitive Symptoms. COGNUM_ALZVR - Age-related Cognitive Decline, Computers, Handheld | Not applicable | Unknown | RIVAGES | 150 | 2023-04-17 | 2023-09-13 |
| Study on the Chronic and Acute Effects of Nordic Berry Beverage on Cognitive Function Active berry product, Reference berry-like product - Age-related Cognitive Decline | Not applicable | Completed | Aventure AB | 62 | 2023-01-17 | 2023-07-06 |
| Heart Rate and Breathing Effects on Attention and Memory Brain training, Paced breathing - Aging, Alzheimer Disease | Not applicable | Completed | University of Southern California | 91 | 2023-01-11 | 2026-01-09 |
| Decoding the Cognitive Trajectory of Hong Kong SuperAgers: a Longitudinal Follow-up Study Ageing - Age-related Cognitive Decline, Cognitive Deterioration | Unknown | Chinese University of Hong Kong | 400 | 2022-06-01 | 2023-12-12 | |
| OsteoPreP: Food Supplements for Postmenopausal Bone Health Pendulum WBF-038, Pendulum Placebo - Postmenopausal Osteopenia, Bone Loss, Age Related | Phase 4 | Unknown | Australian Catholic University | 160 | 2022-05-01 | 2024-07-09 |
| Brain Aging: Muscle-to-brain Axis Modulates Physio-cognitive Decline Multi-domain intervention - Age-related Cognitive Decline, Age-related Physiology Decline | Not applicable | Completed | National Yang Ming Chiao Tung University | 102 | 2021-11-01 | 2023-12-26 |
| Development of an Innovative Health Ingredient From Marine By-products for the Healthy Aging Blue fish hydrolysate, Placebo - Memory Impairment, Age-related Cognitive Decline | Not applicable | Completed | Abyss Ingredients | 53 | 2021-09-14 | 2024-01-09 |
| Multi-target Dietary Supplement Tolerability in an Aging Population (MTDSST) Multi-target Dietary Supplement (MTDS) - Aging, Age-related Cognitive Decline | Not applicable | Unknown | Douglas Boreham | 70 | 2021-09-03 | 2023-05-17 |
| TAS Test: Online Motor-cognitive Tests for Early Detection of Alzheimer's Disease Cognitive test scores, clinical diagnosis and blood biomarkers - Alzheimer Disease, Dementia | Recruiting | University of Tasmania | 3000 | 2021-03-05 | 2023-10-30 |
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Cognitive Dysfunction (15) · Dementia (9) · Alzheimer Disease (7) · Motor Activity (7) · Memory Disorders (3) · Frailty (2) · Neurocognitive Disorders (2) · Obesity (2) · Psychological Well-Being (2) · Bipolar Disorder (1) · Breast Neoplasms (1) · Caregiver Burden (1) · Communicable Diseases (1) · Delirium (1) · Dementia, Vascular (1)
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Exercise (7) · Cognitive Training (5) · Brain-Computer Interfaces (2) · Mindfulness-Based Stress Reduction (2) · Aging (1) · Dietary Supplements (1) · Dronabinol (1) · Electroencephalography (1) · Evoked Potentials (1) · Ginkgo biloba extract (1) · Hearing Aids (1) · Hematologic Tests (1) · Metabolic Networks and Pathways (1) · Nutritional Status (1) · Oral Hygiene (1)
Posit Science Corporation (3) · Washington University School of Medicine (3) · Duke-NUS Graduate Medical School (2) · USDA Human Nutrition Research Center on Aging (2) · University of Milano Bicocca (2) · University of South Florida (2) · University of Southern California (2) · Abyss Ingredients (1) · American Academy of Regenerative Medicine (1) · Arizona State University (1) · Australian Catholic University (1) · Aventure AB (1) · Baycrest (1) · Center for Strategic Planning, of the Federal Medical and Biological Agency (1) · Chinese University of Hong Kong (1)
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Barbara Shukitt-Hale, PhD (2) · Eric J Lenze, MD (2) · Hyun Kyu Lee, PhD (2) · Tammy M Scott, PhD (2) · Tih Shih Lee, MD, PhD (2) · Ashley Schnakenberg Martin, PhD (1) · Carol E Greenwood, PhD (1) · Chandramallika Basak, Ph.D. (1) · Deepak C D'Souza, MD (1) · Douglas Boreham, PhD (1) · Duk L. Na, MD,PhD (1) · Edmund Wascher, PhD (1) · Eric Lenze, MD (1)
PMID 12661673, PMID 14590636, PMID 15147597, PMID 16914401, PMID 17365902, PMID 19276547, PMID 20223924, PMID 20434961, PMID 21767731, PMID 23299183, PMID 23341434, PMID 23806438, PMID 24260218, PMID 25030513, PMID 25405755, PMID 25771249, PMID 25898367, PMID 25940230, PMID 26044346, PMID 26707544, PMID 26765946, PMID 27476869, PMID 28386225, PMID 28912076, PMID 29215971, PMID 29407466, PMID 29724228, PMID 30472317, PMID 30534095, PMID 30561718, PMID 30587151, PMID 31226405, PMID 31553501, PMID 32212856, PMID 32923622, PMID 33087078, PMID 34216693, PMID 34515905, PMID 34662523, PMID 34676455, PMID 34682500, PMID 34715151, PMID 34859527, PMID 35139918, PMID 35285810, PMID 35315588, PMID 35476252, PMID 35675345, PMID 35850660, PMID 36341846
2018 (1), R01AG049369 (1), R01AG070349 (1), R01AG072694 (1), R01AG075014 (1), R01AG080652 (1), R21DA058138 (1), R56AG058234 (1)