46 completed, 24 unknown, 19 recruiting, 9 not yet recruiting. 80 Not applicable, 4 Phase 4, 2 Early Phase 1, 2 Phase 2, 2 Phase 3.
Follow ACL Injury: new trials by email Literature Review of ACL Injury trials Research Report on ACL Injury
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Reducing Disparities in Knee Arthroscopy for Adolescents Educational program and patient navigator - Knee Injury, ACL Injury | Not applicable | Not yet recruiting | Ann & Robert H Lurie Children's Hospital of Chicago | 80 | 2027-10-01 | 2026-06-18 |
| A Paradigm Shift in Musculoskeletal Rehabilitation Assessment After ACL Reconstruction Using Near-Infrared Spectroscopy Incremental Interval Test on a Cycle Ergometer - ACL Injury, Hemodynamics | Not yet recruiting | Universitat de Lleida | 129 | 2026-10-01 | 2026-09-10 | |
| Study to Use Oral Losartan to Decrease the Risk of Postoperative Scarring Following (ACL) Reconstruction Losartan, Placebo - ACL Injury, ACL Reconstruction | Phase 4 | Not yet recruiting | Rush University Medical Center | 144 | 2026-08-01 | 2025-12-15 |
| Differences in Outcomes and Failure Rates Between Allografts and Autografts in Revision Anterior Cruciate Ligament Reconstruction ACL Injury, Graft Failure | Recruiting | Stefano Zaffagnini | 150 | 2026-07-08 | 2026-08-04 | |
| Motor Imagery-Enhanced Rehabilitation Modulates Cortical Plasticity and Functional Recovery After ACL Reconstruction Motor Imagery Therapy (i.e., "mentally practicing movement"), conventional rehabilitation" - ACL Injury | Not applicable | Recruiting | Peking University Third Hospital | 80 | 2026-06-15 | 2026-09-22 |
| The Effect of Accelerated Rehabilitation After Anterior Cruciate Ligament Reconstruction With and Without Suture Tape Reinforcement ACL Reconstruction - ACL Injury | Not applicable | Not yet recruiting | Assiut University | 114 | 2026-05-01 | 2026-04-30 |
| Extended Oral Tranexamic Acid After Anterior Cruciate Ligament Reconstruction Tranexamic Acid (TXA), Placebo - ACL Injury, ACL Tears | Phase 4 | Withdrawn | Campbell Clinic | 2026-04-01 | 2026-03-03 | |
| Post Operative Use of Neuromuscular Electrical Stimulation (NMES) Device for ACLR Patients Zynex NexWave Electrotherapy Device - ACL Reconstruction, ACL Surgery | Not applicable | Enrolling by invitation | University of Kansas Medical Center | 25 | 2026-02-10 | 2026-03-17 |
| Study of Functional Magnetic Resonance Signal Variations in Patients Undergoing Anterior Cruciate Ligament Reconstruction With the Application of a Dedicated Neuromotor Training Effect of targeted neuromotor training in patients undergoing ACL reconstruction on the volumetric activation of cerebral cortex regions during fMRI. - fMRI, ACL Injury | Not applicable | Recruiting | Stefano Zaffagnini | 12 | 2026-02-07 | 2026-02-27 |
| Validation and Cultural Adaptation of the KOOS-ACL Scale for the Italian Population PROMS submition - Scale Reliability Validity, ACL Injury | Not yet recruiting | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | 120 | 2026-01-19 | 2026-02-04 | |
| Comparison of Six-Month Functional Outcomes Following Anterior Cruciate Ligament (ACL) Reconstruction Using Peroneus Longus Tendon Grafts With Adjunctive Secretome Injection Versus Without Secretome Injection Secretome, Placebo - ACL Injury, ACL Tear | Not applicable | Completed | PT. Prodia Stem Cell Indonesia | 24 | 2025-11-14 | 2026-07-23 |
| Comparative Effectiveness of Blood Flow Restriction With or Without Total Motion Release in ACL Rehabilitation Blood Flow Restriction, Total Motion Release - ACL Injury, ACL Reconstruction | Not applicable | Completed | Green International University | 44 | 2025-11-02 | 2026-05-15 |
| Functional Movement Training Versus Functional Stability Training in Post-ACL Surgery Functional Movement training, Functional stability training - ACL Injury | Not applicable | Recruiting | Riphah International University | 32 | 2025-10-15 | 2026-09-30 |
| Effect of Contralateral NMES on Quadriceps Activation After ACL Injury or Surgery Neuromuscular Electrical Stimulation - ACL Injury | Not applicable | Not yet recruiting | Schulthess Klinik | 25 | 2025-09-01 | 2025-09-05 |
| Kinesio Taping for the Knee and Ankle: Acute Impact on Balance, Proprioception, and ACL Risk Kinesio Taping (KT) applied to the knee then ankle, Kinesio Taping (KT) applied to the ankle then knee - ACL Injury, Kinesiotape | Not applicable | Not yet recruiting | Tokat Gaziosmanpasa University | 24 | 2025-08-30 | 2025-08-24 |
| Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction Placebo Split-Belt Training, Split-Belt Training - ACL, Anterior Cruciate Ligament | Not applicable | Recruiting | University of Michigan | 9 | 2025-08-13 | 2026-09-15 |
| Internal Bracing Following ACL Reconstruction Arthrex Internal Brace, ACL Reconstruction - ACL Injury | Not applicable | Withdrawn | NYU Langone Health | 2025-04-01 | 2026-01-09 | |
| Intraoperative Energy Expenditure During ACL Reconstruction Surgery ACL Injury, Meniscal Injuries | Recruiting | ASL Lecce | 80 | 2025-02-01 | 2026-10-13 | |
| MRI Morphology of Femoral Notch in ACL Injury MRI - ACL Injury | Not yet recruiting | Assiut University | 72 | 2025-01-01 | 2024-11-27 | |
| Primary ACL Reconstruction in Patient Over 40 Years: Allograft Versus Autograft ACL reconstruction - ACL, ACL Injury | Unknown | Università Vita-Salute San Raffaele | 40 | 2024-12-01 | 2024-09-05 |
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Anterior Cruciate Ligament Injuries (120) · Knee Injuries (7) · Muscle Weakness (3) · Pain, Postoperative (3) · Athletic Injuries (2) · Kinesiophobia (2) · Osteoarthritis (2) · Pain (2) · Wounds and Injuries (2) · Arthritis (1) · Asthenia (1) · Atrophy (1) · Hip Injuries (1) · Lacerations (1) · Motor Activity (1)
Leg Injuries (120) · Wounds and Injuries (118) · Knee Injuries (113) · Pathological Conditions, Signs and Symptoms (9) · Musculoskeletal Diseases (8) · Neurologic Manifestations (8) · Signs and Symptoms (8) · Pathologic Processes (6) · Joint Diseases (5) · Nervous System Diseases (4) · Arthritis (3) · Muscular Diseases (3) · Neuromuscular Manifestations (3) · Postoperative Complications (3) · Rheumatic Diseases (3)
Blood Flow Restriction Therapy (4) · Anterior Cruciate Ligament Reconstruction (3) · Bupivacaine (2) · Magnetic Resonance Imaging (2) · Rehabilitation (2) · Resistance Training (2) · Acupuncture Therapy (1) · Amyloid (1) · Anti-Inflammatory Agents (1) · Calcium Dobesilate (1) · Congresses as Topic (1) · Control Groups (1) · Dexamethasone (1) · Dexmedetomidine (1) · Educational Status (1)
Assiut University (4) · University Hospital, Caen (4) · Hospital for Special Surgery, New York (3) · I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio (3) · Istituto Ortopedico Rizzoli (3) · NYU Langone Health (3) · Stefano Zaffagnini (3) · University of Michigan (3) · Ann & Robert H Lurie Children's Hospital of Chicago (2) · Chang Gung Memorial Hospital (2) · Children's Hospital Medical Center, Cincinnati (2) · Chinese University of Hong Kong (2) · Mayo Clinic (2) · Peking University Third Hospital (2) · Riphah International University (2)
United States (42) · Italy (13) · France (7) · Canada (4) · Egypt (4) · Turkey (Türkiye) (4) · Belgium (3) · China (3) · Pakistan (3) · Spain (3) · Switzerland (3) · Denmark (2) · Finland (2) · Hong Kong (2) · Indonesia (2)
Chandramouli Krishnan, PT, PhD (2) · Riann M Palmieri-Smith, PhD, ATC (2) · Adam Anz, MD (1) · Adam Weaver, PT, DPT (1) · Alessandro Di Martino, MD (1) · Andrew Bi, MD (1) · Andrew J Sheean, MD (1) · Andrew Watson, MD, MS (1) · Anikar Chhabra, MD (1) · Austin Stone, MD, PhD (1) · Carey Breabaker, MD (1) · Carlos Romero Morales, PT (1) · Chad Lavender, MD (1) · Colin Bond, PhD, MBA (1) · Derek Dewig (1)
PMID 10999422, PMID 15611003, PMID 15870638, PMID 17333120, PMID 17908881, PMID 18292988, PMID 18678953, PMID 19170587, PMID 19962074, PMID 20805695, PMID 21287823, PMID 21678095, PMID 22421565, PMID 22672794, PMID 22892410, PMID 23302260, PMID 24198658, PMID 24352823, PMID 25547048, PMID 25635874, PMID 25733936, PMID 26714740, PMID 27357530, PMID 27474385, PMID 28451617, PMID 28590374, PMID 29741923, PMID 30944945, PMID 30974516, PMID 32247421, PMID 32755488, PMID 34126566, PMID 34471447, PMID 34916884, PMID 35101085, PMID 35366082, PMID 35962841, PMID 36476466, PMID 37347015, PMID 38238809, PMID 39047990, PMID 39159822, PMID 39221503, PMID 40101801, PMID 40181441, PMID 40194659, PMID 40365171, PMID 42459597, PMID 42544937, PMID 9430571
R21AR082643 (2), 2025 (1), K23AR084596 (1), R01AR055563 (1)