18 completed, 1 terminated. 6 Phase 1, 6 Phase 2, 5 Phase 3, 2 Not applicable, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Completed 6 |
| Phase 2 | 6 | Completed 6 |
| Phase 3 | 5 | Completed 5 |
| Not applicable | 2 | Completed 2 |
| Phase 4 | 2 | Completed 1, Terminated 1 |
| Early Phase 1 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Over-the-counter NSAIDS on Cough Reflex Sensitivity in Patients with Upper Respiratory Tract Infections Flurbiprofen Oral Lozenge, Difflam, Flurbiprofen 8.75 MG - Cough, Upper Respiratory Tract Infections | Early Phase 1 | Completed | University of Melbourne | 101 | 2023-07-01 | 2024-12-06 |
| Buprenorphine Used With Treatment Resistant Depression in Older Adults venlafaxine XR, buprenorphine, Placebo - Major Depressive Disorder, Depression | Phase 1 / Phase 2 | Completed | Washington University School of Medicine | 18 | 2016-06-01 | 2019-06-04 |
| Study to Evaluate the Safety and Tolerability of Mucinex™(Guaifenesin) 600 mg Extended-Release Bi-Layer Tablets in the Treatment of Otherwise Healthy Patients With Symptoms of Cough, Thickened Mucus and Chest Congestion Mucinex™ extended-release (SE) - Healthy Subjects | Phase 4 | Completed | Reckitt Benckiser LLC | 552 | 2015-01-24 | 2019-03-19 |
| Incomplete Response in Late-Life Depression: Getting to Remission With Buprenorphine venlafaxine, buprenorphine, placebo - Major Depressive Disorder, Depression | Phase 1 / Phase 2 | Completed | Centre for Addiction and Mental Health | 56 | 2014-12-01 | 2018-07-26 |
| Placebo-Controlled Onset-of-Action Study of Flurbiprofen Utilizing the Double-Stopwatch Method flurbiprofen, placebo - Acute Pharyngitis, Sore Throat | Phase 3 | Completed | Reckitt Benckiser LLC | 122 | 2013-09-01 | 2017-09-28 |
| Mucinex® ER 600 mg Bi-Layer Tablet Fed and Fasted Mucinex® - Healthy Subjects | Phase 1 | Completed | Reckitt Benckiser LLC | 36 | 2013-05-29 | 2019-03-27 |
| Evaluation of Tolerance and Acceptability of a Coated Condom Test condom with new Xanthan gum condom coating - Tolerance and Acceptability of a New Condom Coating | Not applicable | Completed | Reckitt Benckiser LLC | 50 | 2012-09-01 | 2017-09-11 |
| Safety & Performance Study of Verruca Treatment Device Medical Device - Verruca, Plantar Wart | Not applicable | Completed | Reckitt Benckiser LLC | 35 | 2012-06-01 | 2017-10-11 |
| Study to Evaluate the Pharmacokinetics of Mucinex® 1200 mg Extended-Release Tablet Mucinex® - Healthy Subjects | Phase 1 | Completed | Reckitt Benckiser LLC | 24 | 2011-10-11 | 2019-02-28 |
| Safety and Efficacy of Mucinex and IR Guaifenesin the Treatment of Symptoms of Acute Upper Respiratory Tract Infections Mucinex, Immediate-release Guaifenesin, Placebo - Acute Upper Respiratory Tract Infection | Phase 2 / Phase 3 | Completed | Reckitt Benckiser LLC | 2810 | 2011-09-01 | 2013-11-14 |
| Study to Evaluate the Pharmacokinetics of Guaifenesin in Adults and Adolescents Children's Mucinex® Grape Flavor - Healthy Subjects | Phase 1 | Completed | Reckitt Benckiser LLC | 24 | 2011-06-18 | 2019-06-17 |
| Acute Cough Study In Children Dextromethorphan, Placebo - Common Cold, Infections, Upper Respiratory Tract | Phase 4 | Terminated | Pfizer | 140 | 2010-12-01 | 2012-09-20 |
| Buprenorphine for Late-Life Treatment Resistant Depression Buprenorphine - Depression | Phase 2 | Completed | University of Pittsburgh | 15 | 2010-05-01 | 2018-03-09 |
| Evaluating the Effect of Mucinex 1200mg on Mucociliary and Cough Clearance During an Acute Respiratory Infection Mucinex, Placebo - Acute Respiratory Infection | Phase 2 | Completed | Reckitt Benckiser LLC | 38 | 2010-04-01 | 2018-09-19 |
| A Study of Flurbiprofen 8.75 mg Lozenge in Patients With Pharyngitis placebo, flurbiprofen, acetaminophen 650mg - Pharyngitis | Phase 3 | Completed | Reckitt Benckiser LLC | 198 | 2009-11-01 | 2017-09-21 |
| A Study of Flurbiprofen 8.75 mg Lozenge in Patient With Pharyngitis Placebo, Flurbiprofen - Pharyngitis | Phase 3 | Completed | Reckitt Benckiser LLC | 204 | 2009-11-01 | 2017-09-21 |
| Ibuprofen/Acetaminophen Versus Nurofen Plus® and Panadeine® Extra Dental Pain Study Ibuprofen/acetaminophen, Ibuprofen/acetaminophen (higher dose), Nurofen Plus® - Post-operative Pain | Phase 3 | Completed | Reckitt Benckiser LLC | 678 | 2009-01-01 | 2018-09-17 |
| Study to Evaluate Drug-drug Interactions of Guaifenesin and Hydrocodone Bitartrate Humibid®, Hydrocodone Bitartrate, Humibid® and Hydrocodone Bitartrate tablet - Healthy Subjects | Phase 1 | Completed | Reckitt Benckiser LLC | 24 | 2007-05-05 | 2019-06-20 |
| Study of Two Formulations of Buprenorphine HCl in Opioid-dependent Subjects on Buprenorphine Maintenance Therapy (Study P04451) (COMPLETED) Buprenorphine hydrochloride marketed sublingual tablet (Subutex), Buprenorphine hydrochloride fast dissolving tablet (FDT) - Opioid Dependency | Phase 2 | Completed | Indivior Inc. | 52 | 2005-09-01 | 2023-04-11 |
Depression (3) · Depressive Disorder, Major (3) · Pharyngitis (3) · Cough (2) · Respiratory Tract Infections (2) · Common Cold (1) · Deglutition Disorders (1) · Pain, Postoperative (1) · Toothache (1) · Warts (1)
Acetylcysteine (4) · Buprenorphine (4) · Flurbiprofen (4) · Guaifenesin (4) · Acetaminophen (2) · Buprenorphine, Naloxone Drug Combination (2) · Venlafaxine Hydrochloride (2) · Benzydamine (1) · Codeine (1) · Dextromethorphan (1) · Equipment and Supplies (1) · Hydrocodone (1) · Ibuprofen (1) · acetaminophen, codeine drug combination (1)
United States (9) · United Kingdom (2) · Australia (1) · Canada (1)
Timothy J Shea, BS (2) · Daniel M Blumberger, MD (1) · Eric J Lenze, MD (1) · Jordan F Karp, M.D. (1) · Stephen Daniels (1) · Stuart Mazzone, PhD (1) · Timothy Shea, BS (1) · William Bennett, PhD (1)
PMID 25296661, PMID 24988909, PMID 25191915, PMID 26462765, PMID 27146963, PMID 29381110, PMID 31632154, PMID 31846575
KL2RR024154 (1)