15 completed, 2 unknown, 1 suspended, 1 withdrawn. 9 Phase 4, 4 Not applicable, 3 Phase 2, 2 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 9 | Completed 7, Unknown 1, Withdrawn 1 |
| Not applicable | 4 | Completed 2, Suspended 1, Unknown 1 |
| Phase 2 | 3 | Completed 3 |
| Phase 3 | 2 | Completed 2 |
| Phase 1 | 1 | Completed 1 |
Follow acetaminophen, codeine drug combination: new trials by email Literature Review of acetaminophen, codeine drug combination trials Research Report on acetaminophen, codeine drug combination
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cannabinoid vs Opioid for Photorefractive Keratectomy Pain Control oral cannabinoid, oral codeine/acetaminophen - Photorefractive Keratectomy, Myopia | Phase 2 | Completed | University of Florida | 35 | 2024-02-01 | 2025-08-07 |
| An Randomized Control Trial Comparing Two Drug Combinations for Pain Management After Third Molars Surgery diclofenac / acetaminophen /codeine, ibuprofen/acetaminophen/codeine - Impacted Third Molar Tooth, PAIN | Not applicable | Suspended | University of Zimbabwe | 78 | 2023-03-01 | 2023-01-05 |
| Paracetamol Vs Caffeine Vs Codeine in the Management of Post Traumatic Pain in Emergencies Paracetamol, Paracetamol Codeine, Paracetamol caféine - Acute Pain Due to Trauma | Phase 3 | Completed | University of Monastir | 1500 | 2022-11-01 | 2023-06-28 |
| Celecoxib vs. Acetaminophen/Codeine/Caffeine for Post-operative Analgesia in Rhinoplasty. Celecoxib 200mg, Acetaminophen, Codeine Drug Combination - Pain, Postoperative, Surgery--Complications | Phase 4 | Unknown | Blake Raggio | 60 | 2020-03-01 | 2020-08-04 |
| Minimizing Narcotic Analgesics After Endocrine Surgery Acetaminophen 500Mg Cap, Tylenol #3 Oral Tablet, Tramadol - Thyroid Cancer, Thyroid Nodule | Phase 4 | Completed | Minerva A Romero Arenas | 126 | 2018-03-09 | 2021-05-11 |
| Acetaminophen/Codeine vs Acetaminophen/Ibuprofen for Pain Control and Patient Satisfaction After Hand Surgery Acetaminophen/Ibuprofen, Acetaminophen/Codeine - Pain, Postoperative | Phase 4 | Completed | University of Pennsylvania | 144 | 2015-12-01 | 2019-02-18 |
| Comparative Efficacy of 4 Oral Analgesics Oxycodone/acetaminophen, Hydrocodone/acetaminophen, Codeine/acetaminophen - Pain | Phase 4 | Completed | Montefiore Medical Center | 416 | 2015-07-01 | 2018-02-13 |
| Bioequivalence Study of Co-codamol 15mg/500mg Capsules vs Co-codamol 30mg/500mg Tablets in Healthy Subjects co-codamol 15mg/500mg capsule, co-codamol 30mg/500mg tablet - Healthy | Phase 1 | Completed | Galen Limited | 50 | 2014-09-23 | 2017-09-12 |
| Treatment of Chronic Pain From Osteoarthritis Codeine/paracetamol, Oxycodone/naloxone - Chronic Pain | Phase 4 | Withdrawn | Fondazione IRCCS Policlinico San Matteo di Pavia | 2013-06-01 | 2017-04-19 | |
| Comparison of Two Combinations of Opioid and Non-opioid Analgesics for Acute Periradicular Abscess Fixed-dose oral tablet of codeine/ acetaminophen every 4 hours for 3 days, Fixed-dose oral tablet of tramadol/ acetaminophen every 4 hours for 3 days - Periapical Abscess | Not applicable | Completed | Federal University of Rio Grande do Sul | 27 | 2013-04-01 | 2016-04-25 |
| Efficacy of Preoperative Administration of Paracetamol-codeine on Pain Following Impacted Mandibular Third Molar Surgery Paracetamol Codeine, Placebo Oral Tablet - To Control Pain After Third Molar Surgery | Phase 4 | Completed | University of Roma La Sapienza | 32 | 2013-02-21 | 2017-02-10 |
| Ibuprofen Versus Codeine. Is One Better for Post-operative Pain Relief Following Reduction of Paediatric Forearm Fractures? Acetaminophen and Ibuprofen, Acetaminophen and Codeine - Fracture, Pain | Not applicable | Unknown | University of Manitoba | 50 | 2012-07-01 | 2013-07-25 |
| Analgesic Effect of Paracetamol, Paracetamol + Codeine, Ibuprofen and Their Combination Ibuprofen + Paracetamol, Ibuprofen + Paracetamol + Codeine, Paracetamol + Codeine - Pain, Postoperative | Phase 4 | Completed | Ullevaal University Hospital | 200 | 2009-06-01 | 2016-03-30 |
| A Study to Compare Oxycodone/Naloxone Prolonged Release Against Codeine/Paracetamol in the Treatment of Moderate to Severe Chronic Low Back Pain or Pain Due to Osteoarthritis Oxycodone/Naloxone, Codeine/Paracetamol - Osteoarthritis, Back Pain | Phase 4 | Completed | Napp Pharmaceuticals Limited | 247 | 2009-02-01 | 2011-11-02 |
| Ibuprofen/Acetaminophen Versus Nurofen Plus® and Panadeine® Extra Dental Pain Study Ibuprofen/acetaminophen, Ibuprofen/acetaminophen (higher dose), Nurofen Plus® - Post-operative Pain | Phase 3 | Completed | Reckitt Benckiser LLC | 678 | 2009-01-01 | 2018-09-17 |
| Buprenorphine in the Treatment of Osteoarthritis (OA) in the Elderly Buprenorphine, Codeine paracetamol - Osteoarthritis | Phase 4 | Completed | Napp Pharmaceuticals Limited | 219 | 2006-03-01 | 2011-06-14 |
| SB-705498 Dental Pain Study After Tooth Extraction SB705498 400 mg, SB705498 1000 mg, Placebo - Toothache | Phase 2 | Completed | GlaxoSmithKline | 145 | 2005-12-07 | 2019-01-28 |
| Comparison of Acetaminophen With Codeine and Ibuprofen for Children With Injuries ibuprofen, acetaminophen with codeine - Pain | Not applicable | Completed | University of California, San Diego | 68 | 2002-11-01 | 2007-05-17 |
| Chiropractic Care, Medication, and Self-Care for Neck Pain Chiropractic spinal manipulation, Acetaminophen, Self-care - Neck Pain | Phase 2 | Completed | National Center for Complementary and Integrative Health (NCCIH) | 270 | 2001-09-01 | 2008-01-25 |
Pain (7) · Pain, Postoperative (5) · Agnosia (4) · Osteoarthritis (3) · Acute Pain (2) · Toothache (2) · Back Pain (1) · Chronic Pain (1) · Fractures, Bone (1) · Goiter (1) · Hyperopia (1) · Inflammation (1) · Lymphoma, Follicular (1) · Myopia (1) · Neck Pain (1)
Napp Pharmaceuticals Limited (2) · Blake Raggio (1) · Federal University of Rio Grande do Sul (1) · Fondazione IRCCS Policlinico San Matteo di Pavia (1) · Galen Limited (1) · GlaxoSmithKline (1) · Minerva A Romero Arenas (1) · Montefiore Medical Center (1) · National Center for Complementary and Integrative Health (NCCIH) (1) · Reckitt Benckiser LLC (1) · Ullevaal University Hospital (1) · University of California, San Diego (1) · University of Florida (1) · University of Manitoba (1) · University of Monastir (1)
United States (7) · United Kingdom (4) · Canada (2) · Italy (2) · Norway (1) · South Korea (1) · Tunisia (1) · Zimbabwe (1)
David Bell, MD (1) · David Steinberg, MD (1) · Gaute Lyngstad, DDS (1) · Henry A Reinhart, MD (1) · Jamil Asaria, MD (1) · Janet H Friday (1) · Lasse A Skoglund, DDS, DSci (1) · Maria Paola Cristalli, DDS (1) · Massimo Allegri, MD (1) · Minerva A Romero Arenas, MD, MPH (1) · Nouira Semir (1) · Prof Philip Conaghan (1) · Samuel K Snyder, MD (1) · Stephen Daniels (1)
PMID 21477658, PMID 22213489, PMID 28325960, PMID 29114833, PMID 37349498, PMID 42524865
2005 (1), 2014 (1)