9 completed, 5 terminated, 2 withdrawn, 1 recruiting. 17 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 17 | Completed 9, Terminated 5, Withdrawn 2, Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Nitrogen: new trials by email Literature Review of Nitrogen trials Research Report on Nitrogen
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nitrous Oxide for PTSD Nitrous Oxide, Midazolam, Nitrogen - PTSD | Phase 2 | Terminated | VA Office of Research and Development | 1 | 2021-10-07 | 2023-03-03 |
| Efficacy of Nitrous Oxide in OCD: Pilot Study Nitrous Oxide, Nitrogen - Obsessive-Compulsive Disorder | Phase 2 | Recruiting | Stanford University | 45 | 2021-04-17 | 2025-08-27 |
| iNOPulse for COVID-19 Inhaled nitric oxide (iNO), Nitrogen gas, Oxygen gas - COVID-19, Hypoxemia | Phase 2 | Withdrawn | Roger Alvarez | 2020-12-01 | 2020-08-19 | |
| Effects of Prolonged Delivery of Nitric Oxide Gas on Plasma Reduction-Oxidation Reactions in Cardiac Surgical Patients Nitrogen Gas for Inhalation, Blood withdrawal, Nitric Oxide - Cardiovascular Diseases, Oxidative Stress | Phase 2 | Withdrawn | Massachusetts General Hospital | 2019-07-25 | 2025-12-02 | |
| Inhaled Gaseous Nitric Oxide (gNO) Antimicrobial Treatment of Difficult Bacterial and Viral Lung (COVID-19) Infections Nitric Oxide 0.5 % / Nitrogen 99.5 % Gas for Inhalation - Respiratory Tract Infections, Corona Virus Infection | Phase 2 | Terminated | Chris Miller | 13 | 2017-10-24 | 2021-07-16 |
| Inhaled Nitric Oxide After Out-of-Hospital Cardiac Arrest Nitric Oxide, Nitrogen - Heart Arrest, Out-Of-Hospital | Phase 2 | Terminated | Cameron Dezfulian | 57 | 2017-08-26 | 2022-04-25 |
| EMONO for the Treatment of Peripheral Neuropathic Pain Medical Air, EMONO - Neuralgia | Phase 2 | Completed | Air Liquide Santé International | 287 | 2016-11-01 | 2018-09-21 |
| Nitrous Oxide as Treatment for Major Depression - a Pilot Study Nitrous Oxide, Placebo - Depression, Major Depressive Disorder | Phase 2 | Completed | Washington University School of Medicine | 21 | 2012-11-01 | 2020-01-27 |
| Evaluation of the Efficacy and Safety of Inhaled Nitric Oxide as Adjunctive Treatment for Cerebral Malaria in Children inhaled nitric oxide, Placebo - Malaria, Cerebral | Phase 2 | Completed | Epicentre | 92 | 2011-09-01 | 2016-03-02 |
| Trial of Inhaled Nitric Oxide (iNO) on Ischemia / Reperfusion Injury During Orthotopic Liver Transplantation With Marginal Grafts Inhaled Nitric Oxide (iNO), Placebo Arm (Nitrogen) - Liver Transplant | Phase 2 | Completed | Baylor Research Institute | 23 | 2010-07-01 | 2026-01-28 |
| Efficacy Study to Evaluate the Effect of Nitric Oxide on the Treatment of Tinea Pedis (Athlete's Foot) Nitric Oxide, Nitrogen - Tinea | Phase 2 | Completed | Nitric BioTherapeutics, Inc | 50 | 2008-12-01 | 2010-02-03 |
| Study to Evaluate if Inhaled Nitric Oxide Improves Liver Function After Transplantation inhaled nitric oxide, nitrogen gas - Reperfusion Injury, Liver Injury | Phase 2 / Phase 3 | Completed | University of Alabama at Birmingham | 80 | 2008-04-01 | 2014-11-06 |
| Examining the Use of Non-Invasive Inhaled Nitric Oxide to Reduce Chronic Lung Disease in Premature Newborns Inhaled Nitric Oxide (iNO), Nitrogen (placebo) - Bronchopulmonary Dysplasia | Phase 2 | Completed | University of Colorado, Denver | 124 | 2007-01-01 | 2017-06-15 |
| Nitric Oxide in Myocardial Infarction Size Nitric Oxide, Placebo - Acute Myocardial Infarction, ST Elevation MI | Phase 2 | Terminated | Mallinckrodt | 29 | 2006-06-01 | 2019-11-21 |
| The Effects of Nitric Oxide for Inhalation in Right Ventricular Infarction Patients inhaled nitric oxide, nitrogen gas - Right Ventricular Infarction | Phase 2 | Terminated | Mallinckrodt | 3 | 2006-03-01 | 2016-09-09 |
| Safety and Tolerability of Inhaled Nitric Oxide in Patients With Cystic Fibrosis Nitric Oxide for Inhalation, Nitrogen - Cystic Fibrosis | Phase 1 / Phase 2 | Completed | Mallinckrodt | 18 | 2004-07-01 | 2019-11-13 |
| The Effects of Nitric Oxide for Inhalation During Left Ventricular Assists Device (LVAD) Implantation Nitric Oxide, Nitrogen - Congestive Heart Failure | Phase 2 | Completed | Mallinckrodt | 150 | 2003-07-01 | 2016-08-22 |
COVID-19 (2) · Bronchopulmonary Dysplasia (1) · Cardiovascular Diseases (1) · Coronavirus Infections (1) · Cystic Fibrosis (1) · Depression (1) · Depressive Disorder, Major (1) · Heart Diseases (1) · Heart Failure (1) · Hypoxia (1) · Inflammation (1) · Malaria (1) · Malaria, Cerebral (1) · Neuralgia (1) · Obsessive-Compulsive Disorder (1)
Mallinckrodt (4) · Air Liquide Santé International (1) · Baylor Research Institute (1) · Cameron Dezfulian (1) · Chris Miller (1) · Epicentre (1) · Massachusetts General Hospital (1) · Nitric BioTherapeutics, Inc (1) · Roger Alvarez (1) · Stanford University (1) · University of Alabama at Birmingham (1) · University of Colorado, Denver (1) · VA Office of Research and Development (1) · Washington University School of Medicine (1)
United States (13) · Canada (4) · Belgium (2) · Germany (2) · United Kingdom (2) · France (1) · Poland (1) · Spain (1) · Uganda (1)
James Baldassarre, MD (2) · Blair Smith, MD (1) · Cameron Dezfulian, MD (1) · Carolyn I Rodriguez, MD PhD (1) · Clark Cross, MD (1) · Devin E Eckhoff, MD (1) · Didier Bouhassira, MD (1) · Jeremy D Road, MD (1) · John D Lang, MD (1) · John Kinsella, MD (1) · John S Bynon, MD (1) · Juliet Mwanga-Amumpaire, Dr (1) · Keith A Jones, MD (1) · Lorenzo Berra, MD (1) · Luc Frenette, MD (1)
PMID 24533048, PMID 25063725, PMID 33044394, PMID 33769417, PMID 35050957, PMID 37585253
I01CX001789 (1), P50HL084923 (1)