23 completed, 6 recruiting, 2 active not recruiting, 2 terminated. 35 Phase 2, 8 Phase 3, 6 Phase 1.
Follow Nicotine Replacement Therapy: new trials by email Literature Review of Nicotine Replacement Therapy trials Research Report on Nicotine Replacement Therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| DOSE-UP: Dose Optimization for Smoking and E-Cigarette Use Pharmacotherapy Text- and web-based support, Nicotine Replacement Therapy (NRT, nicotine patch), Nicotine replacement therapy lozenge - Dual Use of Cigarettes and E-cigarettes | Phase 2 | Not yet recruiting | Medical University of South Carolina | 321 | 2026-11-01 | 2026-10-15 |
| Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation Varenicline (VAR), Nicotine lozenge (NRT), Smartphone intervention with adherence components (COMBO-A) - Smoking Cessation | Phase 2 | Recruiting | University of Oklahoma | 496 | 2026-07-21 | 2026-08-19 |
| Enhancing Smoking Cessation for African American People Everywhere ESCAPE app + NRT, quiSTART app + NRT, Control (CTRL) - ESCAPE Intervention+NRT, quitSTART Intervention+NRT | Phase 2 | Recruiting | University of Houston | 300 | 2026-06-30 | 2026-07-13 |
| Semaglutide for Post-Smoking Cessation Weight Management semaglutide 2.4mg, Placebo, Nicotine Replacement Therapy (NRT, nicotine patch) - Obesity, Overweight | Phase 2 | Recruiting | The University of Texas Health Science Center, Houston | 197 | 2024-04-23 | 2026-09-21 |
| Evaluating Smoking Cessation Interventions for PWH in South Africa Varenicline, Nicotine patch, Nicotine gum - Smoking Cessation, HIV | Phase 2 / Phase 3 | Recruiting | Johns Hopkins University | 660 | 2023-11-27 | 2026-10-19 |
| Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD active repetitive transcranial magnetic stimulation, sham repetitive transcranial magnetic stimulation, cognitive behavioral therapy for smoking cessation - Tobacco Use Disorder | Phase 2 | Recruiting | VA Office of Research and Development | 50 | 2023-10-31 | 2026-02-18 |
| Overcoming Nicotine Dependence to Enable Quitting Nicotine Replacement Therapy (NRT) Sampling, Practice Quitting (PQ) Counseling, Motivational Interviewing (MI) Counseling - Tobacco Use, Smoking Cessation | Phase 1 / Phase 2 | Recruiting | Rush University Medical Center | 780 | 2023-03-24 | 2026-09-09 |
| Incentives for Oklahoma Tobacco Helpline Engagement in Persistent Poverty Counties Coaching calls, Nicotine replacement therapy, Financial Incentives - Cigarette Smoking, Nicotine Dependence | Phase 2 | Completed | University of Oklahoma | 165 | 2022-03-09 | 2024-12-30 |
| Mobile App for Smoking Cessation and Mental Health Smart-T Mental Health and NRT, Smart-T Mental Health+ and NRT, QuitGuide + NRT - Smoking Cessation, Mental Illness | Phase 2 | Active not recruiting | University of Oklahoma | 64 | 2021-12-14 | 2026-05-01 |
| Heart Rate Variability Biofeedback for Smoking Cessation Treatment Cognitive-Behavioral Smoking Cessation, Heart Rate Variability Biofeedback, Nicotine patch - Tobacco Smoking | Phase 2 | Completed | Rutgers, The State University of New Jersey | 28 | 2021-11-29 | 2024-05-01 |
| Preloading With Nicotine Replacement Therapy in HIV-positive Smokers to Improve Self-Efficacy and Quit Attempts Nicoderm CQ 21Mg/24Hr Transdermal System - Tobacco Use Cessation | Phase 2 / Phase 3 | Completed | Brown University | 49 | 2021-09-01 | 2025-04-06 |
| STARS (Smoking Treatment And Remote Sampling) Study Varenicline 0.5 MG, Nicotine Replacement Therapy (NRT) - Smoking, Smoking Cessation | Phase 1 / Phase 2 | Completed | Medical University of South Carolina | 652 | 2021-02-08 | 2026-02-17 |
| Electronic Cigarettes as a Harm Reduction Strategy in Individuals With Substance Use Disorder E cigarettes, Nicotine Replacement Therapy - Cigarette Smoking, Addiction | Phase 2 | Completed | NYU Langone Health | 48 | 2020-10-27 | 2024-12-20 |
| Effectiveness of Combination Varenicline and Oral Nicotine Replacement Therapy (COMBO) Varenicline, Oral Nicotine Replacement Therapy (NRT), Medication Reminders - Smoking Cessation | Phase 2 | Terminated | University of Oklahoma | 34 | 2020-01-07 | 2024-02-06 |
| Smartphone Based Smoking Cessation Intervention Smart-T + NRT, QuitGuide + NRT - Smoking Cessation | Phase 2 / Phase 3 | Completed | University of Oklahoma | 454 | 2019-08-26 | 2025-08-17 |
| Text Messaging-Based Smoking Cessation Program for Homeless Youth Group counseling and nicotine replacement, Group counseling, nicotine replacement, and text messaging support - Cigarette Smoking | Phase 1 / Phase 2 | Completed | RAND | 77 | 2019-05-30 | 2020-07-22 |
| Heart Rate Variability Biofeedback for Smoking Cessation Cognitive-Behavioral Smoking Cessation, Heart Rate Variability Biofeedback (HRVB), Transdermal Nicotine patch - Tobacco Smoking | Phase 2 | Completed | Rutgers, The State University of New Jersey | 10 | 2019-04-24 | 2020-08-25 |
| PRecision Interventions for SMoking in the SCCS Nicotine patch, Varenicline, Nicotine metabolism - Tobacco Use Cessation | Phase 2 / Phase 3 | Completed | Vanderbilt University Medical Center | 67 | 2018-05-18 | 2020-06-01 |
| Studying Partial-agonists for Ethanol and Tobacco Elimination in Russians With HIV (St PETER HIV) Varenicline, Cytisine, Nicotine Replacement Therapy - HIV Infection, Alcohol Use | Phase 2 / Phase 3 | Completed | Boston Medical Center | 400 | 2017-07-19 | 2020-12-17 |
| Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day Very low nicotine content (VLNC) cigarettes and nicotine replacement therapy (NRT), Reduce cigarettes per day (CPD) with nicotine replacement therapy (NRT) - Tobacco Use Disorder | Phase 2 / Phase 3 | Completed | University of Vermont | 74 | 2017-02-08 | 2022-10-04 |
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Smoking Cessation (22) · Smoking (11) · Tobacco Use Disorder (10) · Cigarette Smoking (6) · Tobacco Use Cessation (4) · Tobacco Smoking (3) · Tobacco Use (3) · Vaping (2) · Alcohol Drinking (1) · Behavior, Addictive (1) · Cardiovascular Diseases (1) · Coronary Disease (1) · Depression (1) · Depressive Disorder, Major (1) · HIV Infections (1)
University of Oklahoma (5) · National Institute on Drug Abuse (NIDA) (3) · Mayo Clinic (2) · Mclean Hospital (2) · Medical University of South Carolina (2) · Rutgers, The State University of New Jersey (2) · VA Office of Research and Development (2) · Boston Medical Center (1) · Brown University (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Evotec Neurosciences GmbH (1) · Johns Hopkins University (1) · M.D. Anderson Cancer Center (1) · McNeil AB (1) · NYU Langone Health (1)
United States (31) · Germany (1) · Russia (1) · South Africa (1) · United Kingdom (1)
Jon O Ebbert, MD (2) · Alla Radicke, MD (1) · Amanda Mathew, PhD (1) · Anne Joseph, MD (1) · Darla E. Kendzor, Ph.D. (1) · Darla E. Kendzor, PhD (1) · Darla Kendzor, PhD (1) · Dorothy Hatsukami, Ph.D. (1) · Elisabeth Kruse, PhD (1) · Eric A Dedert, PhD (1) · Hilary A Tindle, MD, MPH (1) · Jan Blalock, PhD (1) · Jasjit S. Ahluwalia, MD (1) · Jeffrey H Samet, MA, MA, MPH (1)
PMID 20060229, PMID 21928117, PMID 22761006, PMID 23873976, PMID 24075893, PMID 25361769, PMID 30664539, PMID 31106492, PMID 31867643, PMID 31934869, PMID 32075695, PMID 32501274, PMID 32658536, PMID 33792551, PMID 33852730, PMID 34375409, PMID 34611902, PMID 35930287, PMID 37230961, PMID 37889541, PMID 38491559, PMID 39477130, PMID 40543725, PMID 40554081, PMID 40810943, PMID 42101840
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