13 completed, 4 recruiting, 1 unknown. 18 Phase 3, 8 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 18 | Completed 13, Recruiting 4, Unknown 1 |
| Phase 2 | 8 | Completed 7, Recruiting 1 |
Follow Nicotine Replacement Therapy: new trials by email Literature Review of Nicotine Replacement Therapy trials Research Report on Nicotine Replacement Therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Semaglutide for Smoking Cessation in Patients With Diabetes Semaglutide, Nicotine replacement - Diabetes Mellitus, Type 2, Nicotine Addiction | Phase 3 | Recruiting | Ottawa Heart Institute Research Corporation | 100 | 2026-02-13 | 2026-09-08 |
| Tobacco Education and Lung Health Study (TEAL) Phone-based Tobacco Treatment, Nicotine Replacement, and Stepped Care Intervention, E-Referral to the Tobacco Quitline - Smoking Cessation | Phase 3 | Recruiting | Georgetown University | 1188 | 2024-02-22 | 2026-02-17 |
| Evaluating Smoking Cessation Interventions for PWH in South Africa Varenicline, Nicotine patch, Nicotine gum - Smoking Cessation, HIV | Phase 2 / Phase 3 | Recruiting | Johns Hopkins University | 660 | 2023-11-27 | 2026-10-19 |
| Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement MORE and MI and NRT, MORE and No MI and NRT, Support Group and MI and NRT - Polysubstance Abuse, Opioid Use | Phase 3 | Recruiting | Rutgers, The State University of New Jersey | 420 | 2023-09-05 | 2026-07-17 |
| Preloading With Nicotine Replacement Therapy in HIV-positive Smokers to Improve Self-Efficacy and Quit Attempts Nicoderm CQ 21Mg/24Hr Transdermal System - Tobacco Use Cessation | Phase 2 / Phase 3 | Completed | Brown University | 49 | 2021-09-01 | 2025-04-06 |
| Metabolism Informed Smoking Treatment: The MIST RCT Post-discharge automated phone calls (IVR) with option to connect with a tobacco coach., Nicotine Replacement Therapy, Varenicline - Smoking | Phase 3 | Completed | Vanderbilt-Ingram Cancer Center | 606 | 2020-11-17 | 2025-12-05 |
| Smartphone Based Smoking Cessation Intervention Smart-T + NRT, QuitGuide + NRT - Smoking Cessation | Phase 2 / Phase 3 | Completed | University of Oklahoma | 454 | 2019-08-26 | 2025-08-17 |
| PRecision Interventions for SMoking in the SCCS Nicotine patch, Varenicline, Nicotine metabolism - Tobacco Use Cessation | Phase 2 / Phase 3 | Completed | Vanderbilt University Medical Center | 67 | 2018-05-18 | 2020-06-01 |
| Studying Partial-agonists for Ethanol and Tobacco Elimination in Russians With HIV (St PETER HIV) Varenicline, Cytisine, Nicotine Replacement Therapy - HIV Infection, Alcohol Use | Phase 2 / Phase 3 | Completed | Boston Medical Center | 400 | 2017-07-19 | 2020-12-17 |
| Optimizing Tobacco Dependence Treatment in the Emergency Department Brief Negotiated Interview (BNI), Nicotine replacement therapy (NRT), CT Smokers Quitline (QL) - Tobacco Use Disorder | Phase 3 | Completed | Yale University | 1056 | 2017-02-13 | 2020-12-04 |
| Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day Very low nicotine content (VLNC) cigarettes and nicotine replacement therapy (NRT), Reduce cigarettes per day (CPD) with nicotine replacement therapy (NRT) - Tobacco Use Disorder | Phase 2 / Phase 3 | Completed | University of Vermont | 74 | 2017-02-08 | 2022-10-04 |
| The Use of Nicotine Patches Together With E-cigarettes (With and Without Nicotine) for Smoking Cessation Nicotine patch, e-cigarette, Nicotine - Smoking Cessation | Phase 3 | Completed | University of Auckland, New Zealand | 1124 | 2016-03-01 | 2021-08-19 |
| Smoking Cessation Versus Long-term Nicotine Replacement Among High-risk Smokers Standard Smoking Cessation, Extended Nicotine Replacement Therapy, Nicotine replacement therapy - Smoking, Pulmonary Disease, Chronic Obstructive | Phase 3 | Completed | University of Kansas Medical Center | 398 | 2014-05-01 | 2017-10-06 |
| The Canadian HIV Quit Smoking Trial: Tackling the Co-morbidities of Depression and Cardiovascular Disease in HIV+ Smokers Nicotine Replacement Therapy (NRT), Varenicline, HIV Tailored Quit Smoking Counseling - HIV, Smoking Cessation | Phase 3 | Unknown | Ottawa Hospital Research Institute | 256 | 2014-01-01 | 2015-12-14 |
| CPT and Smoking Cessation Cognitive Processing Therapy (CPT), Bupropion, nicotine replacement therapy (NRT) - Stress Disorders, Post-Traumatic, Smoking | Phase 2 / Phase 3 | Completed | VA Office of Research and Development | 69 | 2013-12-11 | 2018-09-11 |
| Intensive Smoking-cessation Intervention Versus Smoking-cessation Advice in Smear-positive Patients With Pulmonary Tuberculosis nicotine replacement therapy - Tuberculosis | Phase 3 | Completed | All India Institute of Medical Sciences | 800 | 2010-11-01 | 2017-10-13 |
| Highdose Nicotine Patch Therapy for Smokeless Tobacco Use nicotine replacement therapy (nicotine patches), placebo NRT - Smokeless Tobacco Use | Phase 2 / Phase 3 | Completed | Mayo Clinic | 52 | 2010-07-01 | 2014-05-19 |
| Disease Management for Smoking Cessation High intensity disease management, Low intensity disease management, Comparison group - Smoking Cessation | Phase 3 | Completed | University of Kansas Medical Center | 750 | 2009-06-01 | 2017-06-07 |
Smoking Cessation (9) · Smoking (5) · Tobacco Use Disorder (5) · Tobacco Use (3) · Tobacco Use Cessation (3) · Alcohol Drinking (1) · Coronary Disease (1) · Diabetes Mellitus, Type 2 (1) · HIV Infections (1) · Inflammation (1) · Pulmonary Disease, Chronic Obstructive (1) · Stress Disorders, Post-Traumatic (1) · Tuberculosis (1) · Vaping (1)
University of Kansas Medical Center (2) · All India Institute of Medical Sciences (1) · Boston Medical Center (1) · Brown University (1) · Georgetown University (1) · Johns Hopkins University (1) · Mayo Clinic (1) · Ottawa Heart Institute Research Corporation (1) · Ottawa Hospital Research Institute (1) · Rutgers, The State University of New Jersey (1) · University of Auckland, New Zealand (1) · University of Oklahoma (1) · University of Vermont (1) · VA Office of Research and Development (1) · Vanderbilt University Medical Center (1)
United States (12) · Canada (2) · India (1) · New Zealand (1) · Russia (1) · South Africa (1)
Edward F Ellerbeck, MD (1) · Edward F. Ellerbeck, MD, MPH (1) · Eric A Dedert, PhD (1) · Hilary A Tindle, MD, MPH (1) · Hilary Tindle, MD, MPH (1) · Jeffrey H Samet, MA, MA, MPH (1) · Jon O Ebbert, MD (1) · Jonathan E Golub, PhD MPH (1) · Louise Balfour, PhD (1) · Maureen Sanderson, PhD, RD, MPH (1) · Michael S Businelle, PhD (1) · Natalie Walker, PhD (1) · Neil Martison (1) · Nina Cooperman, PsyD (1) · Patricia Cioe, PhD (1)
PMID 34611902, PMID 16801293, PMID 18065851, PMID 18236294, PMID 18397444, PMID 18420774, PMID 18544464, PMID 19349629, PMID 19901150, PMID 21233256, PMID 22770436, PMID 23873976, PMID 29287665, PMID 30646142, PMID 30664539, PMID 31106492, PMID 31515173, PMID 31867643, PMID 32658536, PMID 35930287, PMID 37142273, PMID 38491559, PMID 39868569, PMID 40543725, PMID 40810943
R01CA101963 (1), R01CA201873 (1), R01CA221819 (1), R01CA232516 (1), R01DA057631 (1), R21CA261233 (1), U01AA020780 (1), U01CA261626 (1)