8 completed, 5 unknown, 2 recruiting. 15 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 15 | Completed 8, Unknown 5, Recruiting 2 |
| Phase 2 | 3 | Completed 1, Recruiting 1, Unknown 1 |
Follow Dextromethorphan: new trials by email Literature Review of Dextromethorphan trials Research Report on Dextromethorphan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Efficacy of EXV-802 and EXV-801 in the Treatment of Agitation in Alzheimer's Disease Dementia EXV-802, Placebo, EXV-801 - Agitation Associated With Alzheimer's Disease Dementia | Phase 2 / Phase 3 | Recruiting | Exciva GmbH | 300 | 2026-02-02 | 2026-08-14 |
| A Trial of Dextromethorphan and Bupropion Sustained-Release Tablets in Patients With Major Depressive Disorder Dextromethorphan and Bupropion Sustained-Release Tablets, Placebo - Major Depressive Disorder (MDD) | Phase 3 | Recruiting | CSPC Ouyi Pharmaceutical Co., Ltd. | 388 | 2025-04-11 | 2025-05-06 |
| Dextromethorphan, Memantine Monotherapy, or Combined Use of Dextromethorphan and Memantine in Amphetamine Addiction Dextromethorphan, Memantine, Dextromethorphan and memantine - Amphetamine Addiction, Pharmacotherapy | Phase 2 / Phase 3 | Unknown | National Cheng-Kung University Hospital | 120 | 2020-08-11 | 2020-12-29 |
| Evaluating the Efficacy of Dextromethorphan/Quinidine in Treating Irritability in Huntington's Disease Dextromethorphan/quinidine 20mg/10mg (DM/Q 20mg/10mg), Placebo - Huntington Disease, Irritability | Phase 3 | Completed | The University of Texas Health Science Center, Houston | 20 | 2019-08-05 | 2024-01-05 |
| Open-Label Safety Study of AXS-05 in Subjects With Depression AXS-05 (dextromethorphan and bupropion) oral tablets - Major Depressive Disorder, Treatment Resistant Depression | Phase 3 | Completed | Axsome Therapeutics, Inc. | 876 | 2019-07-08 | 2022-10-12 |
| Dextromethorphan as a Novel Non-opioid Adjunctive Agent for Pain Control in Medication Abortion Dextromethorphan Hydrobromide, Avicel PH101 (Microcrystalline Cellulose NF) for Compounding, Oxycodone - Abortion in First Trimester | Phase 3 | Completed | Study Investigator-Sponsor | 156 | 2018-07-28 | 2020-08-06 |
| Combination of Dextromethorphan and Memantine in Treating Bipolar Disorder Dextromethorphan, Memantine, dextromethorphan+memantine - Bipolar Disorder II | Phase 3 | Unknown | National Cheng-Kung University Hospital | 300 | 2013-01-01 | 2017-07-11 |
| An Open-Label Immunogenicity and Pharmacokinetics Study of Daclizumab High Yield Process Prefilled Syringe in Relapsing Remitting Multiple Sclerosis Midazolam, Caffeine, S-warfarin - Relapsing-Remitting Multiple Sclerosis | Phase 3 | Completed | Biogen | 133 | 2011-11-01 | 2017-03-14 |
| Dextromethorphan and Silymarin in Chronic Kidney Disease (CKD) Patients Dextromethorphan, Silymarin, sugar pill - Proteinuria | Phase 3 | Unknown | National Cheng-Kung University Hospital | 45 | 2010-01-01 | 2010-03-24 |
| Combined Therapy of Methadone and Dextromethrophan Dextromethorphan - Opioid Abuse | Phase 3 | Unknown | National Cheng-Kung University Hospital | 1500 | 2008-04-01 | 2010-08-26 |
| Safety and Efficacy of AVP-923 in PBA Patients With ALS or MS dextromethorphan hydrobromide 20 mg and quinidine sulfate 10 mg, dextromethorphan hydrobromide 30 mg and quinidine sulfate 10 mg, Placebo - Pseudobulbar Affect (PBA) | Phase 3 | Completed | Avanir Pharmaceuticals | 326 | 2007-12-01 | 2017-04-12 |
| Add-on Dextromethorphan in Bipolar Disorders Valproate, Dextromethorphan 60 mg per day, Placebo - Bipolar Disorder | Phase 3 | Completed | National Cheng-Kung University Hospital | 300 | 2007-06-01 | 2013-09-17 |
| Add-On Therapy to Risperidonein Schizophrenia Dextromethorphan - Schizophrenia | Phase 2 / Phase 3 | Completed | National Cheng-Kung University Hospital | 161 | 2005-01-01 | 2013-02-28 |
| Independent Studies of Dextromethorphan and of Donepezil Hydrochloride for Rett Syndrome dextromethorphan, donepezil hydrochloride - Rett Syndrome | Phase 3 | Unknown | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 90 | 2004-09-01 | 2005-06-24 |
| Treatment for Chronic Pain in Patients With Advanced Cancer dextromethorphan hydrobromide, morphine sulfate - Chronic Myeloproliferative Disorders, Leukemia | Phase 3 | Completed | NCIC Clinical Trials Group | 87 | 1998-06-11 | 2020-04-03 |
Bipolar Disorder (2) · Depressive Disorder, Major (2) · Agnosia (1) · Amphetamine-Related Disorders (1) · Amyotrophic Lateral Sclerosis (1) · Blast Crisis (1) · Burkitt Lymphoma (1) · Depression (1) · Depressive Disorder, Treatment-Resistant (1) · Hodgkin Disease (1) · Huntington Disease (1) · Immunoblastic Lymphadenopathy (1) · Immunoglobulin Light-chain Amyloidosis (1) · Inflammation (1) · Leukemia (1)
National Cheng-Kung University Hospital (6) · Avanir Pharmaceuticals (1) · Axsome Therapeutics, Inc. (1) · Biogen (1) · CSPC Ouyi Pharmaceutical Co., Ltd. (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Exciva GmbH (1) · NCIC Clinical Trials Group (1) · Study Investigator-Sponsor (1) · The University of Texas Health Science Center, Houston (1)
United States (7) · Taiwan (6) · Canada (2) · Czechia (2) · Poland (2) · Argentina (1) · Brazil (1) · China (1) · Germany (1) · Hungary (1) · Italy (1) · Slovakia (1) · Spain (1) · United Kingdom (1)
Ru-Band Lu, MD (4) · Adrian Hepner, M.D. (1) · Eduardo Bruera, MD (1) · Erin L Furr Stimming, MD (1) · Junne-Ming Sung, MD (1) · SakkuBai R. Naidu, MD (1) · Tzu-Yun Wang (1)
PMID 17397698, PMID 20839238, PMID 22730040, PMID 27411694, PMID 32115672, PMID 36332661, PMID 41499296
P01HD024448 (1)