47 completed, 5 recruiting, 3 unknown, 1 active not recruiting. 57 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 57 | Completed 47, Recruiting 5, Unknown 3, Active not recruiting 1, Terminated 1 |
| Phase 2 | 4 | Completed 3, Unknown 1 |
Follow Dextromethorphan: new trials by email Literature Review of Dextromethorphan trials Research Report on Dextromethorphan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Multiple-dose Study Investigating the Drug-drug Interaction Potential and QTc Effects of Fosmanogepix in Healthy Adult Subjects Fosmanogepix, Placebo, The medicine cocktail (caffeine, bupropion, flurbiprofen, omeprazole, dextromethorphan and midazolam) - Healthy Adult Participants | Phase 1 | Recruiting | Basilea Pharmaceutica | 42 | 2026-10-01 | 2026-10-19 |
| An Early-Stage Study in Multiple Clinics of How Afimkibart May Affect the Body's Processing of Medicines That Rely on Cytochrome P450 Enzymes in Participants With Ulcerative Colitis Afimkibart, Caffeine, Warfarin - Active Ulcerative Colitis | Phase 1 | Recruiting | Hoffmann-La Roche | 25 | 2026-06-29 | 2026-10-16 |
| A Study of Psychedelics in Healthy Older Adults With Low Well-being Psilocybin (drug), Dextromethorphan (DXM) - Anhedonia in Healthy Volunteers, Older Adults (50-90 Years) | Phase 1 | Recruiting | Jennifer Mitchell | 80 | 2026-06-01 | 2026-09-09 |
| A Study to Investigate the Effect of Capivasertib on the Pharmacokinetics of Oral Dextromethorphan (CYP2D6 Substrate) in Healthy Participants Dextromethorphan, Capivasertib - Healthy Participants | Phase 1 | Completed | AstraZeneca | 42 | 2026-03-19 | 2026-07-27 |
| A Study Investigating the Change in Metabolism Phenotype in Paediatric, Adolescent & Young Adults With Hodgkin or Non-Hodgkin Lymphoma. Omeprazole, Dextromethorphan - Hodgkin Lymphoma, Non Hodgkin Lymphoma | Phase 1 | Recruiting | Murdoch Childrens Research Institute | 10 | 2025-07-22 | 2026-08-27 |
| Investigation of Psychedelic Effects in Psychoactive Substances Placebo, Psilocybin, Ketamine - Psychedelic Effects in Healthy Volunteers | Phase 1 | Recruiting | Johns Hopkins University | 50 | 2025-02-05 | 2026-02-23 |
| A Study Evaluating the Potential of BMS-984923 to Alter the Systemic Exposure of Three Orally Administered Probe Substrates BMS-984923, Midazolam, Caffeine - Drug Drug Interaction (DDI) | Phase 1 | Active not recruiting | Allyx Therapeutics | 36 | 2024-11-04 | 2025-02-07 |
| Study to Evaluate the Drug-drug Interaction of JMKX001899 in Healthy Subjects JMKX001899, Itraconazole, Midazolam - Solid Tumor, Adult | Phase 1 | Unknown | Jemincare | 72 | 2024-04-01 | 2024-04-04 |
| A Study of IBI351 in Healthy Subjects Itraconazole, IBI351, Dextromethorphan - Healthy Subjects | Phase 1 | Completed | Innovent Biologics (Suzhou) Co. Ltd. | 24 | 2023-03-10 | 2023-10-24 |
| DDI Study of Single Oral Dose of Acoziborole With Sequential Co-administration of Midazolam and Dextromethorphan Acoziborole, Midazolam, Dextromethorphan - Trypanosomiasis, African | Phase 1 | Completed | Drugs for Neglected Diseases | 20 | 2023-02-09 | 2023-07-17 |
| A Drug Interaction Study of LY3871801 in Healthy Participants LY3871801, Methotrexate, Warfarin - Healthy | Phase 1 | Completed | Eli Lilly and Company | 39 | 2022-11-02 | 2023-04-18 |
| A Study of Imlunestrant (LY3484356) in Female Healthy Participants Imlunestrant, Repaglinide, Omeprazole - Healthy | Phase 1 | Completed | Eli Lilly and Company | 113 | 2022-07-07 | 2025-12-12 |
| Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Midazolam, Repaglinide, Dextromethorphan, Metformin, Rosuvastatin and Dolutegravir Midazolam, Repaglinide, Dextromethorphan - Malaria | Phase 1 | Completed | Novartis Pharmaceuticals | 48 | 2022-03-09 | 2022-11-04 |
| PK Study to Assess Drug-drug Interaction and QTc Between Sitravatinib and a Cocktail of Substrates Sitravatinib, Warfarin, Dextromethorphan - Advanced Solid Tumor | Phase 1 | Completed | Mirati Therapeutics Inc. | 40 | 2021-04-08 | 2024-05-08 |
| Phenotyping of High Dose Rifampicin phenotyping cocktail, rifampicin - Tuberculosis | Phase 1 | Completed | Radboud University Medical Center | 25 | 2021-01-07 | 2021-08-17 |
| Drug-drug Interaction Study of KL1333 in Healthy Subjects KL1333, Flurbiprofen, Dextromethorphan - Mitochondrial Disease | Phase 1 | Completed | Abliva AB | 14 | 2020-11-10 | 2021-10-20 |
| Three Dosing Regimens of Dextromethorphan (DXM) Reportedly Used in Major Depressive Disorder Dextromethorphan - MDD, Treatment Resistant Depression | Phase 1 | Completed | Johns Hopkins University | 5 | 2020-03-15 | 2022-11-04 |
| Impact of Nuedexta on Bulbar Physiology and Function in ALS dextromethorphan HBr and quinidine sulfate - Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Completed | University of Florida | 28 | 2019-07-25 | 2023-03-08 |
| Licorice Botanical Dietary Supplements - Metabolism and Safety in Women Licorice, Alprazolam 2 MG, Caffeine 100 MG - Food-drug Interaction | Phase 1 | Completed | University of Illinois at Chicago | 19 | 2019-04-01 | 2023-05-06 |
| Study to Evaluate the Effects of 90 mg Intravenous Infusions of GC4419 on the Single Dose Pharmacokinetics of Dextromethorphan in Healthy Adult Subjects Dextromethorphan HBr, GC4419 - Healthy | Phase 1 | Completed | Galera Therapeutics, Inc. | 13 | 2019-02-10 | 2019-06-19 |
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