23 completed, 2 recruiting, 2 terminated, 2 unknown. 30 Phase 2, 4 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 30 | Completed 23, Recruiting 2, Terminated 2, Unknown 2, Not yet recruiting 1 |
| Phase 1 | 4 | Completed 3, Unknown 1 |
| Phase 3 | 3 | Completed 1, Recruiting 1, Unknown 1 |
Follow Dextromethorphan: new trials by email Literature Review of Dextromethorphan trials Research Report on Dextromethorphan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nintedanib With or Without Dextromethorphan in Patients With Idiopathic Pulmonary Fibrosis (IPF) Nintedanib,Dextromethorphan, Nintedanib,Placebo - Idiopathic Pulmonary Fibrosis (IPF) | Phase 2 | Not yet recruiting | First Affiliated Hospital of Wenzhou Medical University | 60 | 2026-05-12 | 2026-05-13 |
| Safety and Efficacy of EXV-802 and EXV-801 in the Treatment of Agitation in Alzheimer's Disease Dementia EXV-802, Placebo, EXV-801 - Agitation Associated With Alzheimer's Disease Dementia | Phase 2 / Phase 3 | Recruiting | Exciva GmbH | 300 | 2026-02-02 | 2026-08-14 |
| Study of Dextromethorphan in OCD and Related Disorders Fluoxetine, Dextromethorphan - Obsessive-Compulsive Disorder, Illness Anxiety Disorder | Phase 2 | Recruiting | Stanford University | 60 | 2022-01-20 | 2026-05-20 |
| Dextromethorphan, Memantine Monotherapy, or Combined Use of Dextromethorphan and Memantine in Amphetamine Addiction Dextromethorphan, Memantine, Dextromethorphan and memantine - Amphetamine Addiction, Pharmacotherapy | Phase 2 / Phase 3 | Unknown | National Cheng-Kung University Hospital | 120 | 2020-08-11 | 2020-12-29 |
| A Pilot Study: a Non-opioid Technique for Postoperative Adenoidectomy Pain Relief in Pediatric Patients Dextromethorphan, Acetaminophen, Dexmedetomidine - Adenoid Hypertrophy | Phase 2 | Completed | Arlyne Thung | 10 | 2019-08-02 | 2021-02-05 |
| Impact of Nuedexta on Bulbar Physiology and Function in ALS dextromethorphan HBr and quinidine sulfate - Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Completed | University of Florida | 28 | 2019-07-25 | 2023-03-08 |
| Add-on Low Dose Dextromethorphan and Memantine in Patients With Amphetamine-type Stimulants Use Disorder dextromethorphan and memantine (DM+MM), Placebos - Stimulants Use Disorder | Phase 1 / Phase 2 | Completed | Tzu-Yun Wang | 85 | 2018-07-24 | 2020-12-10 |
| Dextromethorphan in Fibromyalgia Dextromethorphan, Placebo - Fibromyalgia | Phase 2 | Completed | University of Alabama at Birmingham | 27 | 2018-06-26 | 2022-08-26 |
| AXS-05 Phase II Trial on Smoking Behavior AXS-05, Bupropion SR - Smoking Cessation, Smoking, Cigarette | Phase 2 | Completed | James Davis | 58 | 2018-03-25 | 2022-12-19 |
| Pilot Study Using an NMDA Antagonist to Modulate Transcranial Direct Current Stimulation (tDCS) Effects on Sensory Discrimination Direct Current Stimulation, Dextromethorphan - Schizophrenia | Phase 1 / Phase 2 | Unknown | University of Ottawa | 12 | 2015-04-01 | 2015-04-27 |
| Histamine Glutamate Antagonism in Stroke Diphenhydramine, Pantoprazole, Famotidine - Acute Cerebrovascular Accident, Cerebral Edema | Phase 2 | Completed | University of Florida | 3 | 2014-12-01 | 2015-12-15 |
| Dextromethorphan in Chemotherapy-induced Peripheral Neuropathy Management Dextromethorphan - Chemotherapy-induced Peripheral Neuropathy | Phase 2 | Terminated | University Hospital, Clermont-Ferrand | 19 | 2014-11-25 | 2022-10-10 |
| A Study to Investigate the Glucose Lowering Effects of Dextromethorphan Alone or in Combination With Sitagliptin in Subjects With Type 2 Diabetes Mellitus (T2DM) After an Oral Glucose Tolerance Test Dextromethorphan, Sitagliptin, Placebo - Type 2 Diabetes Mellitus | Phase 2 | Completed | Profil Institut für Stoffwechselforschung GmbH | 34 | 2013-10-01 | 2017-11-07 |
| Clinical Trial Nuedexta in Subjects With ALS Nuedexta, Matching Placebo - Amyotrophic Lateral Sclerosis (ALS) | Phase 2 | Completed | Center for Neurologic Study, La Jolla, California, | 90 | 2013-04-01 | 2017-03-24 |
| Study of NMDA Antagonists and Neuropathic Pain Dextromethorphan (drug used like antitussive), Memantine (drug used in Alzheimer's disease), Placebo (lactose) - Neuropathic Pain | Phase 2 | Completed | University Hospital, Clermont-Ferrand | 7 | 2012-05-01 | 2026-04-21 |
| Placebo Controlled Trial of Dextromethorphan in Rett Syndrome dextromethorphan, placebo - Rett Syndrome | Phase 2 | Completed | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 57 | 2012-03-01 | 2018-12-04 |
| Nuedexta for the Treatment of Adults With Autism Nuedexta, Placebo - Autism | Phase 2 | Completed | Sutter Health | 13 | 2012-01-24 | 2017-12-08 |
| Trial of Naltrexone and Dextromethorphan for Gulf War Illness naltrexone, Dextromethorphan - Gulf War Illness | Phase 2 | Completed | East Carolina University | 60 | 2012-01-01 | 2016-03-03 |
| Dextromethorphan, Amantadine and Glucose Homeostasis in Diabetes Subjects Dextromethorphan hydrobromide, Amantadine, Pacebo 1 (placebo for Amantadine) - Type 2 Diabetes Mellitus | Phase 2 | Completed | Profil Institut für Stoffwechselforschung GmbH | 20 | 2011-09-01 | 2012-07-12 |
| Dextromethorphan for Diabetic Macular Edema Dextromethorphan hydrobromide - Diabetic Macular Edema | Phase 1 / Phase 2 | Completed | National Eye Institute (NEI) | 7 | 2011-08-01 | 2020-07-28 |
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Neuralgia (3) · Agnosia (2) · Amyotrophic Lateral Sclerosis (2) · Chronic Pain (2) · Diabetes Mellitus (2) · Diabetes Mellitus, Type 2 (2) · Hyperalgesia (2) · Inflammation (2) · Nerve Degeneration (2) · Rett Syndrome (2) · Schizophrenia (2) · Spinal Cord Injuries (2) · Amphetamine-Related Disorders (1) · Autistic Disorder (1) · Body Dysmorphic Disorders (1)
Brigham and Women's Hospital (2) · Hugo W. Moser Research Institute at Kennedy Krieger, Inc. (2) · National Cheng-Kung University Hospital (2) · National Institute of Dental and Craniofacial Research (NIDCR) (2) · Profil Institut für Stoffwechselforschung GmbH (2) · University Hospital, Clermont-Ferrand (2) · University of Florida (2) · Aegerion Pharmaceuticals, Inc. (1) · Arlyne Thung (1) · Center for Neurologic Study, La Jolla, California, (1) · East Carolina University (1) · Exciva GmbH (1) · First Affiliated Hospital of Wenzhou Medical University (1) · James Davis (1) · National Eye Institute (NEI) (1)
United States (21) · Germany (3) · Taiwan (3) · Canada (2) · France (2) · Czechia (1) · Italy (1) · Poland (1) · Slovakia (1) · Spain (1) · United Kingdom (1)
Christine N. Sang, MD, MPH (2) · Tzu-Yun Wang (2) · Alin O Stirban, MD (1) · Alin Stirban, MD (1) · Arlyne Thung, MD (1) · Carol A Parise, PhD (1) · Catherine A Cukras, MD, PhD (1) · Charles O'Brien, M.D., Ph.D. (1) · Danielle Impey, Ph.D. (cand.) (1) · Emily Plowman, PhD (1) · James M Davis, MD (1) · Jarred W Younger, PhD (1) · Jeremy Shefner, MD, PhD (1) · Lauren Tabor, PhD (1)
PMID 22730040, PMID 24948402, PMID 25636304, PMID 26362564, PMID 30584490, PMID 31447547
R01NS041503 (2), 2014 (1)