8 completed, 2 terminated, 2 unknown, 1 recruiting. 13 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 13 | Completed 8, Terminated 2, Unknown 2, Recruiting 1 |
Follow Dextromethorphan: new trials by email Literature Review of Dextromethorphan trials Research Report on Dextromethorphan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism Caffeine Tablet, Bupropion Hydrochloride Capsels, Repaglinide Capsels - Drug Interaction | Not applicable | Completed | Helsinki University Central Hospital | 12 | 2024-08-22 | 2026-03-06 |
| Dextromethorphan for Treatment of Postoperative Pain Dextromethorphan Hydrobromide, Placebo - Post-operative Pain | Not applicable | Recruiting | Nathanael Heckmann | 160 | 2022-09-15 | 2026-03-27 |
| Endobiotics for Phenotyping of Human Cytochrome P450 Enzymes Dextromethorphan 5 MG, Paroxetine 10Mg Tablet, Paroxetine 20Mg Tablet - Healthy | Not applicable | Completed | Jules Desmeules | 40 | 2019-01-01 | 2022-01-04 |
| Impact of Genetic Polymorphism on Drug-Drug Interactions Involving CYP2D6 Dextromethorphan 5 MG, Tramadol 10 mg, Duloxetine 60mg - Healthy | Not applicable | Completed | Jules Desmeules | 34 | 2016-07-01 | 2019-04-19 |
| Effect of Acute Ethanol Consumption on The Activity of Major Cytochrome P450 Enzymes, NAT2 and P-glycoprotein caffeine, tolbutamide, omeprazole, dextromethorphan, digoxin, midazolam single doses, ethanol multiple doses plus caffeine, tolbutamide, omeprazole, dextromethorphan, digoxin, midazolam single doses - AOD Effects and Consequences | Not applicable | Completed | University of Cologne | 16 | 2015-06-01 | 2019-09-09 |
| Drug Metabolism and Antidepressant Omeprazole (10 mg, A02BC01) - Depression | Not applicable | Unknown | University Hospital, Geneva | 100 | 2014-12-01 | 2015-05-08 |
| The Effects of Multiple Dose Fluoxetine and Metabolites on CYP1A2, CYP2C19, CYP2D6 and CYP3A4 Activity Fluoxetine, Lovastatin, Omeprazole, caffeine, midazolam, dextromethorphan - Drug-Drug Interaction, Healthy Volunteers | Not applicable | Completed | University of Washington | 10 | 2011-09-01 | 2018-06-29 |
| Effect of N-methyl D-aspartate (NMDA) Receptor Antagonist Dextromethorphan on Opiods Analgesia and Tolerance in Pediatric Intensive Care Unit Patients Dextromethorphan, Placebo - Pain, Opioid Tolerance | Not applicable | Unknown | King Abdullah International Medical Research Center | 36 | 2011-01-01 | 2015-04-14 |
| Efficacy Study of Dextromethorphan to Treat Rheumatoid Arthritis Dextromethorphan hydrobromide - Rheumatoid Arthritis | Not applicable | Completed | Taichung Veterans General Hospital | 48 | 2010-01-01 | 2015-03-31 |
| Dextromethorphan in Treating Patients With Fatigue Caused by Cancer dextromethorphan hydrobromide - Fatigue, Unspecified Adult Solid Tumor, Protocol Specific | Not applicable | Terminated | University of Medicine and Dentistry of New Jersey | 30 | 2003-10-01 | 2011-05-17 |
| A Pilot Study of Dextromethorphan for the Prevention and Treatment of Methotrexate Neurotoxicity Dextromethorphan - Neurotoxicity Syndromes | Not applicable | Terminated | University of Medicine and Dentistry of New Jersey | 20 | 2003-03-01 | 2009-12-11 |
| Hepatic Drug Biotransformation in Children With Obstructive Sleep Apnea Dextromethorphan, Caffeine - Sleep Apnea | Not applicable | Completed | Virginia Commonwealth University | 69 | 2003-01-01 | 2009-03-19 |
| Study of the Pathogenesis of Rett Syndrome dextromethorphan, topiramate, Donepezil - Rett Syndrome | Not applicable | Completed | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 120 | 1995-01-01 | 2005-06-24 |
Agnosia (1) · Arthritis, Rheumatoid (1) · Depression (1) · Fatigue (1) · Mental Disorders (1) · Neurologic Manifestations (1) · Neurotoxicity Syndromes (1) · Pain (1) · Pain, Postoperative (1) · Rare Diseases (1) · Rett Syndrome (1) · Sleep Apnea Syndromes (1)
Jules Desmeules (2) · University of Medicine and Dentistry of New Jersey (2) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Helsinki University Central Hospital (1) · King Abdullah International Medical Research Center (1) · Nathanael Heckmann (1) · Taichung Veterans General Hospital (1) · University Hospital, Geneva (1) · University of Cologne (1) · University of Washington (1) · Virginia Commonwealth University (1)
United States (4) · Switzerland (2) · Finland (1) · Germany (1) · Saudi Arabia (1)
Celia Lloret-Linares, MD, PhD (1) · Connie Davis, MD. (1) · Der-Yuan Chen, M.D., Ph.D. (1) · Jules A Desmeules, Pr (1) · Mary Jayne Kennedy, Pharm.D. (1) · Nina Isoherranen, PhD. (1) · Peter Cole, MD (1) · Sakkubai Naidu (1) · Susan Goodin, PharmD, FCCP, BCOP (1) · Uwe Fuhr (1)
PMID 24018772, PMID 27867308, PMID 29570971, PMID 32719417, PMID 36991450
2016 (1), 2018 (1), 2023 (1), P01GM032165 (1), P30CA072720 (1)