10 completed, 4 terminated, 2 withdrawn. 16 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 16 | Completed 10, Terminated 4, Withdrawn 2 |
Follow Dextromethorphan: new trials by email Literature Review of Dextromethorphan trials Research Report on Dextromethorphan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dextromethorphan as an Augmentation Agent in Treatment-resistant Schizophrenia Dextromethorphan, Placebo - Treatment Resistant Schizophrenia | Phase 4 | Completed | All India Institute of Medical Sciences, Bhubaneswar | 40 | 2023-08-31 | 2025-05-09 |
| Repurposing of Dextromethorphan as an Adjunct Therapy in Patients With Major Depressive Disorder Selective Serotonin Reuptake Inhibitors, Dextromethorphan, Placebo - Major Depressive Disorder | Phase 4 | Completed | All India Institute of Medical Sciences, Bhubaneswar | 60 | 2022-02-10 | 2023-12-22 |
| Dextromethorphan Added on for Children With Chronic Irritability Dextromethorphan, placebo - Irritable Mood | Phase 4 | Completed | Tri-Service General Hospital (TSGH) | 120 | 2021-05-09 | 2026-10-07 |
| Dextromethorphan Use in Multimodal Analgesia Regimens for Total Knee Arthroplasty Dextromethorphan, Placebo - Concentrate, Acetaminophen - Pain, Postoperative | Phase 4 | Terminated | University of Southern California | 23 | 2017-01-01 | 2019-05-14 |
| Phase 4, Vedolizumab-4002 Post-marketing, Disease-Drug-Drug Interaction Study Caffeine, Losartan, Omeprazole - Colitis, Ulcerative, Crohn Disease | Phase 4 | Withdrawn | Takeda | 2016-11-01 | 2020-10-27 | |
| Effects of Isotretinoin on CYP2D6 Activity Isotretinoin, dextromethorphan - CYP2D6 Polymorphism | Phase 4 | Completed | University of Washington | 33 | 2016-07-26 | 2025-01-28 |
| Dextromethorphan Pediatric Acute Cough Study Dextromethorphan Hydrobromide, Placebo, Cough recording device - Cough | Phase 4 | Terminated | Pfizer | 131 | 2016-02-25 | 2021-04-28 |
| Effectiveness, Safety, and Health-Related Outcomes of NUEDEXTA® in Nursing Home Patients With Pseudobulbar Affect (PBA) NUEDEXTA® - Pseudobulbar Affect (Involuntary Laughing and/or Crying) | Phase 4 | Terminated | Avanir Pharmaceuticals | 5 | 2015-09-01 | 2017-07-03 |
| Evaluation of CYP450 Activities in Diabetic Patients vs. Non-diabetic Subjects CRCHUM-MT cocktail - Type 2 Diabetes | Phase 4 | Completed | Centre hospitalier de l'Université de Montréal (CHUM) | 73 | 2015-04-01 | 2019-07-23 |
| Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo diphenhydramine/phenylephrine/cocoa; dextromethorophan; placebo, diphenhydramine/phenylephrine/cocoa; placebo; dextromethorphan, dextromethorphan; diphenhydramine/phenylephrine/cocoa; placebo - Cough Reflex Sensitivity | Phase 4 | Completed | Montefiore Medical Center | 22 | 2014-01-01 | 2018-02-28 |
| Study to Evaluate Effect of Belatacept on Pharmacokinetics of Inje Cocktail in Healthy Volunteers Caffeine, Losartan, Omeprazole - Transplant Rejection | Phase 4 | Completed | Bristol-Myers Squibb | 45 | 2013-01-01 | 2014-06-27 |
| Does Pre and Postoperative Dextromethorphan Reduce Post-tonsillectomy Pain in Children? Dextromethorphan, Placebo - Pain, Postoperative | Phase 4 | Completed | Dr. Rachel Rooney | 85 | 2012-03-01 | 2020-09-21 |
| Acute Cough Study In Children Dextromethorphan, Placebo - Common Cold, Infections, Upper Respiratory Tract | Phase 4 | Terminated | Pfizer | 140 | 2010-12-01 | 2012-09-20 |
| Assessment of Opioid Analgesia in Sickle Cell Dextromethorphan, Codeine, Morphine - Sickle Cell Disease | Phase 4 | Withdrawn | Children's National Research Institute | 2006-11-01 | 2014-12-23 | |
| Treatment of Acute Sinusitis Acetaminophen, Amoxicillin, Dextromethorphan hydrobromide with guaifenesin - Acute Respiratory Infections, Acute Rhinosinusitis | Phase 4 | Completed | Washington University School of Medicine | 172 | 2006-10-01 | 2012-12-28 |
| Vascular Endothelial Protection Effects of Dextromethorphan Dextromethorphan - Atherosclerosis, Smoking | Phase 4 | Completed | National Cheng-Kung University Hospital | 40 | 2005-03-01 | 2008-01-31 |
Cough (3) · Pain, Postoperative (2) · Anemia, Sickle Cell (1) · Atherosclerosis (1) · Colitis, Ulcerative (1) · Common Cold (1) · Crohn Disease (1) · Depressive Disorder, Major (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 2 (1) · Inflammation (1) · Respiratory Tract Infections (1) · Rhinosinusitis (1) · Schizophrenia, Treatment-Resistant (1) · Sinusitis (1)
All India Institute of Medical Sciences, Bhubaneswar (2) · Pfizer (2) · Avanir Pharmaceuticals (1) · Bristol-Myers Squibb (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Children's National Research Institute (1) · Dr. Rachel Rooney (1) · Montefiore Medical Center (1) · National Cheng-Kung University Hospital (1) · Takeda (1) · Tri-Service General Hospital (TSGH) (1) · University of Southern California (1) · University of Washington (1) · Washington University School of Medicine (1)
United States (9) · India (2) · Taiwan (2) · Canada (1)
Chin-Bin Yeh, M.D., Ph.D. (1) · Hanna Schittek, MD (1) · Jane Garbutt, MB, ChB (1) · Jean-Louis Chiasson, MD (1) · Julia C. Finkel, M.D. (1) · Mary F Hebert, PharmD (1) · Ping-Yen Liu, MD, PhD (1) · Rachel Rooney, MD, FRCPC (1) · Rituparna Maiti, M.D. (1) · Veronique Michaud, BPharm, PhD (1)
PMID 21844413, PMID 22337680, PMID 25673148, PMID 28194724, PMID 28916283, PMID 29439084, PMID 29532791, PMID 29660207, PMID 31099895, PMID 32755625, PMID 33070149, PMID 33904154, PMID 34242798, PMID 37864393, PMID 38688675, PMID 39551007, PMID 41780197
R01GM124264 (1), U01AI064655 (1)