147 completed, 33 unknown, 12 terminated, 10 recruiting. 209 Phase 3, 24 Phase 2.
Follow Vomiting: new trials by email Literature Review of Vomiting trials Research Report on Vomiting
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use Tradipitant, Placebo - Nausea and Vomiting, Obesity | Phase 3 | Recruiting | Vanda Pharmaceuticals | 280 | 2026-03-27 | 2026-04-20 |
| Adding Aprepitant to a Multimodal Strategy for the Prevention of Postoperative Nausea and Vomiting in High-risk Outpatient Surgical Patients Aprepitant 40mg, Placebo - Nausea and Vomiting, Postoperative, Prevention | Phase 3 | Completed | Centre hospitalier de l'Université de Montréal (CHUM) | 260 | 2026-02-27 | 2026-08-27 |
| Olanzapine Plus Metoclopramide for the Prevention of Opioid-Induced Nausea and Vomiting Olanzapine, Metoclopramide - Nausea, Vomiting | Phase 3 | Recruiting | Affiliated Hospital of Qinghai University | 222 | 2026-02-03 | 2026-04-27 |
| Olanzapine for Prevention of Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy Olanzapine Tablets, Placebo - Breakthrough Chemotherapy-Induced Vomiting (CIV) in Pediatric Patients, Pediatric Cancer | Phase 3 | Not yet recruiting | Shanghai Children's Medical Center | 100 | 2025-07-01 | 2025-06-25 |
| Comparison of Dexmedetomidine and Dexamethasone for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy Dexamedomedine, Dexamethasone - Postoperative Nausea and Vomiting | Phase 3 | Completed | Patel Hospital, Pakistan | 68 | 2025-06-01 | 2026-02-23 |
| MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children Melatonin, Isotonic sodium chloride solution - Emergence Delirium | Phase 3 | Recruiting | Arash Afshari | 676 | 2025-01-21 | 2026-08-18 |
| Olanzapine Versus Placebo for Moderately Emetogenic Chemotherapy olanzapine, Placebo - Chemotherapy Induced Nausea and Vomiting | Phase 3 | Recruiting | Mahidol University | 140 | 2025-01-10 | 2025-02-27 |
| To Evaluate the Efficacy and Safety of QLM2010 for Prevention of Chemotherapy-induced Nausea and Vomiting After Highly Emetogenic Chemotherapy. QLM2010 for injection；dexamethasone, fosaprepitant dimeglumine for injection；palonosetron hydrochloride injection；dexamethasone - Chemotherapy-Induced Nausea and Vomiting | Phase 3 | Completed | Qilu Pharmaceutical Co., Ltd. | 665 | 2025-01-03 | 2025-11-18 |
| Antiemetic Fosaprepitant To Remedy Nausea and Vomiting Fosaprepitant 150 mg, Ondansetron 4 mg - Nausea and Vomiting, Nausea | Phase 2 / Phase 3 | Recruiting | Montefiore Medical Center | 200 | 2024-11-13 | 2026-05-18 |
| Efficacy and Safety Study of Aprepitant Injection for Prevention of Post-operative Nausea and Vomiting Aprepitant Injection, Aprepitant Injection Placebo - Post-operative Nausea and Vomiting (PONV) | Phase 3 | Unknown | CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. | 486 | 2024-10-28 | 2024-08-09 |
| A Pilot Study to Evaluate Barhemsys for the Prevention of Postoperative Nausea And Vomiting in the Bariatric Surgery Population Amisulpride IV Prevention, Amisulpride IV Treatment, Placebo Preventative - Post Operative Nausea and Vomiting | Phase 3 | Unknown | Benaroya Research Institute | 100 | 2024-09-13 | 2024-09-26 |
| Opioid Free Versus Opioid Balanced Anesthesia in Ophthalmic Surgery Dexmedetomidine, Fentanyl - Anesthesia and Analgesia, Anesthesia, Endotracheal | Phase 2 / Phase 3 | Unknown | Universitas Indonesia | 104 | 2024-06-01 | 2024-04-30 |
| Prevention and Treatment of CINV Caused by TC Regimen in Gynecological Malignant Tumor Patients Aprepitant Injection - Gynecological Tumor, Ovarian Cancer | Phase 3 | Completed | Sichuan Cancer Hospital and Research Institute | 143 | 2024-05-31 | 2025-12-04 |
| NEPA Combined With Olanzapine, Dexamethasone-sparing for the Effect of CINV in Patients Receiving HEC Regimens Netupitant / Palonosetron Oral Capsule [Akynzeo], Olanzapine, Dexamethasone Oral - Chemotherapy-induced Nausea and Vomiting, Highly Emetogenic Chemotherapy | Phase 3 | Completed | Fudan University | 644 | 2024-05-01 | 2026-04-09 |
| Electroacupuncture Plus Antiemetic Therapy for Chemotherapy-Induced Nausea and Vomiting in Patients With Breast Cancer Electroacupuncture, Antiemetic Therapy, Sham electroacupuncture - Electroacupuncture, Olanzapine-contained Four-drug Antiemetic | Phase 3 | Recruiting | Feixue Song | 370 | 2024-03-07 | 2024-03-21 |
| Oral Dexamethasone for Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy Dexamethasone Oral, Dexamethasone - Postoperative Nausea and Vomiting | Phase 3 | Unknown | Mansoura University | 814 | 2024-03-04 | 2024-03-12 |
| Trial of Itopride 150mg Once a Day Versus Itopride 50 mg Thrice a Day; in Patients With Functional Dyspepsia Itopride Hydrochloride 150 mg extended release tablets, Itopride Hydrochloride 50 mg film coated tablets - Functional Dyspepsia | Phase 3 | Completed | Abbott | 564 | 2024-02-28 | 2026-04-03 |
| An Evaluation the Effect of Superhydration Versus Dextrose 10% for Prevention of Post Operative Nausea and Vomiting After Laparoscopic Cholecystectomy (Prospective Randomised Controlled Study) ringer lactate (20ml/kg), Dextrose 10% - Postoperative Nausea and Vomiting (PONV) | Phase 3 | Completed | Ain Shams University | 204 | 2024-02-25 | 2025-02-26 |
| the Efficacy and Safety of Ondansetron Oral Soluble Pellicles Ondansetron Oral Soluble Pellicles - Nausea and Vomiting | Phase 3 | Unknown | The First Affiliated Hospital of Xinxiang Medical College | 184 | 2024-02-20 | 2024-02-28 |
| Efficacy and Safety Study of Aprepitant Injection for Prevention of Post-operative Nausea and Vomiting Aprepitant Injection, Aprepitant Injection Placebo - Postoperative Nausea and Vomiting | Phase 3 | Completed | Qilu Pharmaceutical (Hainan) Co., Ltd. | 518 | 2024-02-02 | 2025-04-23 |
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Nausea (84) · Postoperative Nausea and Vomiting (65) · Pain, Postoperative (18) · Breast Neoplasms (10) · Neoplasms (10) · Pain (10) · Gastroparesis (8) · Agnosia (5) · Diarrhea (5) · Uterine Cervical Neoplasms (5) · Abdominal Pain (4) · Diabetes Mellitus (4) · Gastroenteritis (4) · Hematemesis (4)
Pathological Conditions, Signs and Symptoms (209) · Signs and Symptoms (209) · Signs and Symptoms, Digestive (208) · Pathologic Processes (74) · Postoperative Complications (68) · Nausea (59) · Neurologic Manifestations (42) · Neoplasms by Site (31) · Neoplasms (30) · Pain (25) · Digestive System Diseases (22) · Gastrointestinal Diseases (21) · Urogenital Diseases (15) · Endocrine System Diseases (13)
Dexamethasone (62) · Ondansetron (39) · Aprepitant (30) · Palonosetron (25) · Granisetron (20) · Olanzapine (16) · Calcium Dobesilate (9) · Metoclopramide (9) · Sodium Chloride (9) · fosaprepitant (9) · Saline Solution (7) · netupitant, palosentron drug combination (7) · casopitant (6) · Gabapentin (5) · ramosetron (5)
Merck Sharp & Dohme LLC (12) · Helsinn Healthcare SA (9) · Acacia Pharma Ltd (6) · GlaxoSmithKline (6) · M.D. Anderson Cancer Center (5) · All India Institute of Medical Sciences (3) · Alliance for Clinical Trials in Oncology (3) · Assiut University (3) · Charleston Laboratories, Inc (3) · Fudan University (3) · Tesaro, Inc. (3) · Vanda Pharmaceuticals (3) · Allergan (2) · Balgrist University Hospital (2) · Duchesnay Inc. (2)
United States (67) · China (21) · Germany (21) · Canada (17) · France (14) · Italy (13) · Russia (13) · Hungary (12) · Egypt (11) · Poland (11) · South Korea (11) · Bulgaria (10) · Denmark (10) · India (10) · Ukraine (10)
Dennis Vargo, MD (3) · Alejandro Gonzalez-Ojeda, M.D., Ph.D. (2) · Fausto Roila, MD (2) · Moataz M Emara, MD, EDAIC (2) · Patrick Zingg, MD (2) · Sameer Bakhshi, MD (2) · A. Riaz, MD (1) · Alana Koehler, MD (1) · Aldo Maina, M.D. (1) · Alex Molassiotis, MD (1) · Alex Sia (1)
PMID 16314401, PMID 19775450, PMID 23062719, PMID 24276953, PMID 26272769, PMID 27410922, PMID 28285236, PMID 30968588, PMID 31094774, PMID 32931400, PMID 10485781, PMID 10824073, PMID 11030465, PMID 11497388, PMID 11773155, PMID 12145072, PMID 12377323, PMID 12562658, PMID 12712486, PMID 12736106, PMID 12784346, PMID 14504060, PMID 14559886, PMID 14635083, PMID 14966097, PMID 15680647, PMID 15837996, PMID 16198982, PMID 16436839, PMID 16766588, PMID 16849762, PMID 18633023, PMID 19135415, PMID 19428297, PMID 19568773, PMID 19805683, PMID 20037151, PMID 20692030, PMID 20692031, PMID 20835873, PMID 20842754, PMID 20843504, PMID 21182781, PMID 21383291, PMID 21436683, PMID 21465325, PMID 21851346, PMID 21872708, PMID 22024310, PMID 22141732
2014 (3), 2008 (2), 2019 (2), U10CA037420 (2), 2005 (1), 2009 (1), 2017 (1), U10CA031946 (1), U10CA081920 (1)