14 completed, 3 unknown, 2 not yet recruiting, 2 recruiting. 23 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 23 | Completed 14, Unknown 3, Not yet recruiting 2, Recruiting 2, Terminated 1, Withdrawn 1 |
| Phase 2 | 1 | Completed 1 |
Follow Venous Insufficiency: new trials by email Literature Review of Venous Insufficiency trials Research Report on Venous Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Design and Rationale of the COLT Study Colchicine 0.5 MG Oral Tablet, Placebo - Venous Thrombosis Deep (Limbs), Post-thrombotic Syndrome | Phase 3 | Not yet recruiting | Azienda Sanitaria Locale ASL 6, Livorno | 940 | 2026-06-01 | 2026-02-25 |
| Colchicine to Quench the Inflammatory Response After Deep Vein Thrombosis (The Conquer-DVT Pilot Trial) Colchicine 0.5 mg po, Placebo 0.5 mg po - Venous Thromboembolism | Phase 3 | Recruiting | Ottawa Hospital Research Institute | 150 | 2025-07-07 | 2026-07-23 |
| Immunosuppressive Therapy Alone Versus Plus Oral Anticoagulation in the Treatment of VT Associated With Behcet's Disease Placebo plus immunosuppression, Rivaroxaban plus immunosupression - Behcet Disease, Behcet Disease and Vascular Involvement | Phase 3 | Not yet recruiting | Marmara University | 110 | 2025-04-30 | 2025-04-13 |
| The MUFFIN-PTS Trial Micronized Purified Flavonoid Fraction, Placebo - Post-Thrombotic Syndrome | Phase 3 | Unknown | Sir Mortimer B. Davis - Jewish General Hospital | 88 | 2022-02-04 | 2023-11-30 |
| Statins for Venous Event Reduction in Patients With Venous Thromboembolism Rosuvastatin Calcium, Placebo Oral Tablet - Venous Thromboembolism, Blood Clot | Phase 3 | Recruiting | Ottawa Hospital Research Institute | 2700 | 2021-02-10 | 2026-01-15 |
| Resolution Enhancement by a Supplemental Obstruction Lessening Venoactive Drug for Eight Weeks in Deep Vein Thrombosis Hydroxyethylrutoside - Deep Vein Thrombosis | Phase 3 | Completed | Maastricht University Medical Center | 44 | 2020-12-08 | 2024-03-01 |
| Pediatric High-Risk Deep Venous Thrombosis Lytic Outcomes Trial Recombinant tissue plasminogen activator (rt-PA), Standard Anticoagulation Therapy - Deep Vein Thrombosis, Post-Thrombotic Syndrome | Phase 3 | Withdrawn | University of Colorado, Denver | 2018-07-01 | 2018-08-10 | |
| Study to Assess the Efficacy and Safety of Endolex Forte VErsus Diosmin and Hesperidin in Reducing VeNous Insufficiency Endolex Forte®, A combination of diosmin and hesperidin - Chronic Venous Insufficiency | Phase 3 | Unknown | SunWave Pharma | 120 | 2016-11-01 | 2016-10-28 |
| Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers HP802-247, HP802-247 Vehicle - Venous Ulcer, Venous Stasis Ulcer | Phase 3 | Terminated | Healthpoint | 252 | 2013-11-01 | 2016-10-03 |
| Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2 HP802-247, Vehicle - Venous Leg Ulcers | Phase 3 | Completed | Healthpoint | 155 | 2012-11-01 | 2017-07-26 |
| Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI) Flavonid, Daflon - Venous Insufficiency | Phase 3 | Unknown | Azidus Brasil | 140 | 2010-10-01 | 2010-10-27 |
| Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis Recombinant tissue plasminogen activator (rt-PA) - Deep Vein Thrombosis, Venous Thrombosis | Phase 3 | Completed | Washington University School of Medicine | 692 | 2009-11-01 | 2018-03-29 |
| Assess the Efficacy and Tolerability of Antistax Film-coated Tablets in Patients With Chronic Venous Insufficiency Red vine leaf extract (AS 195), Placebo - Venous Insufficiency | Phase 3 | Completed | Boehringer Ingelheim | 250 | 2009-03-01 | 2014-05-16 |
| THERMES ET VEINES: Spa for Prevention of Leg Ulcers Immediate spa treatment, Late spa treatment - Venous Insufficiency, Leg Ulcer | Phase 3 | Completed | Association Francaise pour la Recherche Thermale | 425 | 2008-05-01 | 2012-10-01 |
| Evaluation of the Duration of Therapy for Thrombosis in Children Shortened duration (6 weeks) of anticoagulant therapy, Conventional duration (3 months) of anticoagulant therapy, No Intervention - Venous Thrombosis | Phase 3 | Completed | Johns Hopkins All Children's Hospital | 532 | 2008-03-01 | 2025-06-18 |
| Efficacy and Tolerability CVI (A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial (CVI) Read vine leaf extract (AS 195) - Venous Insufficiency | Phase 3 | Completed | Boehringer Ingelheim | 202 | 2006-03-01 | 2013-10-29 |
| The Influence of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Disease urea contained compressing stockings, compressing stockings - Venous Insufficiency | Phase 2 / Phase 3 | Completed | University Medicine Greifswald | 42 | 2005-06-01 | 2005-09-20 |
| Clinical Study of BNS003 on Swelling in Legs Due to Venous Reflux BNS003 - Venous Insufficiency | Phase 3 | Completed | Boehringer Ingelheim | 180 | 2004-07-01 | 2014-08-08 |
| The SOX Trial: Compression Stockings to Prevent the Post-Thrombotic Syndrome Knee-length, graduated elastic compression stocking, Knee-length, placebo stocking - Deep Venous Thrombosis | Phase 3 | Completed | Sir Mortimer B. Davis - Jewish General Hospital | 806 | 2004-06-01 | 2014-08-18 |
| Evaluation of a Venous-Return Assist Device (Venowave) to Treat Post-Thrombotic Syndrome: A Randomized Controlled Trial Veno-device (Venowave) - Postphlebitic Syndrome | Phase 3 | Completed | Hamilton Health Sciences Corporation | 32 | 2004-05-01 | 2008-07-22 |
Showing 20 of 23. Sign in to see all of them.
Postthrombotic Syndrome (12) · Venous Thrombosis (11) · Venous Thromboembolism (5) · Postphlebitic Syndrome (3) · Thrombosis (3) · Varicose Ulcer (3) · Inflammation (2) · Ulcer (2) · Varicose Veins (2) · Wounds and Injuries (2) · Behcet Syndrome (1) · Leg Ulcer (1)
Cardiovascular Diseases (23) · Vascular Diseases (23) · Embolism and Thrombosis (14) · Thrombosis (11) · Thromboembolism (5) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Skin Diseases (4) · Skin and Connective Tissue Diseases (4) · Peripheral Vascular Diseases (3) · Phlebitis (3) · Skin Ulcer (3) · Venous Thrombosis (3) · Leg Ulcer (2)
AS 195 (2) · Colchicine (2) · Tissue Plasminogen Activator (2) · Antistax (1) · Diosmin (1) · Heparin (1) · Hesperidin (1) · Hydroxyethylrutoside (1) · Immune Tolerance (1) · Immunosuppression Therapy (1) · Polidocanol (1) · Rivaroxaban (1) · Rosuvastatin Calcium (1) · Tablets (1) · Tinzaparin (1)
Boehringer Ingelheim (4) · Healthpoint (2) · Ottawa Hospital Research Institute (2) · Sir Mortimer B. Davis - Jewish General Hospital (2) · Aalborg University Hospital (1) · Association Francaise pour la Recherche Thermale (1) · Azidus Brasil (1) · Azienda Sanitaria Locale ASL 6, Livorno (1) · Hamilton Health Sciences Corporation (1) · Johns Hopkins All Children's Hospital (1) · Maastricht University Medical Center (1) · Marmara University (1) · SunWave Pharma (1) · University Hospital, Grenoble (1) · University Medicine Greifswald (1)
Canada (7) · Germany (4) · United States (4) · France (3) · Austria (2) · Czechia (2) · Netherlands (2) · Australia (1) · Belgium (1) · Brazil (1) · Denmark (1) · Hungary (1) · Ireland (1) · Israel (1) · Italy (1)
Tommy Lee, MSHS (2) · Alexandre Frederico, Doctor (1) · Andrea Ladwig (1) · Benedicte Laursen, MD, DMSc (1) · Calin Giurcaneanu, MD (1) · Clive Kearon, MB, MRCP, FRCP(C), PhD (1) · Fatma Alibaz-Oner, Prof (1) · Herbert B Slade, MD (1) · Herbert B. Slade, MD (1) · Jean-Philippe Galanaud, MD, PhD (1)
PMID 29037354, PMID 20047905, PMID 21239190, PMID 23537968, PMID 24135621, PMID 24315521, PMID 25183442, PMID 29211671, PMID 30586751, PMID 30699446, PMID 31354089, PMID 31592728, PMID 31843251, PMID 33141449, PMID 33445952, PMID 34518263, PMID 35015038, PMID 39321425, PMID 39968829
U01HL088476 (1), U01HL130048 (1)