14 completed, 3 unknown, 2 terminated. 19 Phase 2, 6 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 19 | Completed 14, Unknown 3, Terminated 2 |
| Phase 1 | 6 | Completed 3, Unknown 2, Terminated 1 |
| Phase 3 | 1 | Completed 1 |
Follow Venous Insufficiency: new trials by email Literature Review of Venous Insufficiency trials Research Report on Venous Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mechanisms of Deep Vein Thrombosis (DVT) and Vein Wall Fibrosis Rosuvastatin - Post-thrombotic Syndrome, Deep Vein Thrombosis Leg | Phase 1 / Phase 2 | Unknown | Khanh Nguyen | 30 | 2021-06-01 | 2021-10-15 |
| Study Evaluating Efficacy and Safety of Crisaborole in Adults With Stasis Dermatitis crisaborole ointment, vehicle ointment - Stasis Dermatitis | Phase 2 | Completed | Pfizer | 66 | 2020-06-26 | 2022-05-02 |
| A Study Evaluating ClariVein With a Sclerosing Agent for the Treatment of Venous Insufficiency ClariVein RES, Sodium Tetradecyl Sulfate 1% Injection, Sodium Tetradecyl Sulfate 3% Injection - Venous Insufficiency | Phase 2 | Terminated | Vascular Insights, LLC | 19 | 2017-09-22 | 2022-03-02 |
| Cooling Leg and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence Cooling gel pack, Cooling cotton pack - Venous Hypertension Ulcers, Venous Stasis Ulcer | Phase 2 | Completed | Medical University of South Carolina | 140 | 2015-06-01 | 2021-06-30 |
| Venavine Intensive® in the Treatment of Symptoms Associated With Chronic Venous Insufficiency Gelatine capsule, Venavine Intensive® - Venous Insufficiency | Phase 2 | Completed | University of Johannesburg | 40 | 2015-02-01 | 2016-05-19 |
| The Efficacy of Venavine Intensive® on the Quality of Life in Females With Chronic Venous Insufficiency Gelatine Capsule, Venavine Intensive® - Venous Insufficiency | Phase 2 | Completed | University of Johannesburg | 40 | 2015-01-01 | 2016-05-19 |
| The Use of Intermittent Pneumatic Compression Device for Symptomatic Relief in Patients With Post Thrombotic Syndrome ActiveCare+S.F.T 3rd generation - Post Thrombotic Syndrome | Phase 2 | Unknown | Hadassah Medical Organization | 20 | 2012-07-01 | 2012-07-17 |
| Efficacy of RPh201 Applied Topically for the Treatment of Hard to Heal Chronic Ulcerated Wounds RPh201, botanical drug product - Chronic Wound | Phase 1 / Phase 2 | Terminated | Regenera Pharma Ltd | 4 | 2011-12-01 | 2018-09-04 |
| Cooling Lower Leg Skin to Prevent Venous Leg Ulcers in Patients With Poor Vein Circulation Cryotherapy: Cooling gel wrap, Usual care - Venous Disease, Venous Vascular Diseases and Syndromes | Phase 1 / Phase 2 | Completed | Medical University of South Carolina | 197 | 2011-08-01 | 2016-04-05 |
| Endoluminale Obliteration Der Stammvene Mit Dem 1470nm Laser Versus VNUS Closure Fast Laser, Radiofrequency - Venous Insufficiency | Phase 1 / Phase 2 | Unknown | Ludwig Boltzmann Institute for Operative Laparoscopy | 140 | 2010-06-01 | 2013-10-30 |
| Endovascular Treatment for Chronic Cerebrospinal Venous Insufficiency (CCSVI) balloon angioplasty and/or stenting - Multiple Sclerosis | Phase 1 / Phase 2 | Completed | Euromedic Specialist Clinics, Poland | 100 | 2010-03-01 | 2015-02-10 |
| Study of Thymosin Beta 4 in Patients With Venous Stasis Ulcers Thymosin Beta 4, Placebo - Venous Stasis Ulcers | Phase 2 | Completed | RegeneRx Biopharmaceuticals, Inc. | 72 | 2006-07-01 | 2010-03-30 |
| Evaluation of DermStream(tm) - an Irrigation Product for Chronic Wound Management DermaStream(tm) application and Streaming of Saline - Venous Insufficiency, Diabetes | Phase 1 / Phase 2 | Completed | EnzySurge | 11 | 2006-03-01 | 2008-08-01 |
| Compression Device Safety Study Placebo - No device worn, Prototype device(unnamed)-A battery operated inflatable pneumatic cuffs - Venous Insufficiency | Phase 2 | Completed | ConvaTec Inc. | 16 | 2005-07-01 | 2008-10-31 |
| The Influence of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Disease urea contained compressing stockings, compressing stockings - Venous Insufficiency | Phase 2 / Phase 3 | Completed | University Medicine Greifswald | 42 | 2005-06-01 | 2005-09-20 |
| Community RCT of the Effectiveness of Two Compression Bandaging Technologies Four-layer Bandage (Elastomeric), Short-stretch Bandage (Non-elastomeric) - Venous Ulcer | Phase 2 | Completed | Queen's University | 426 | 2004-01-01 | 2015-11-20 |
| Efficacy of Antistax® in Improving Microcirculation of the Skin in the Leg in Patients Suffering From Chronic Venous Insufficiency Antistax®, Placebo - Venous Insufficiency | Phase 2 | Completed | Boehringer Ingelheim | 71 | 2002-04-01 | 2014-07-16 |
| Physical Conditioning in Management of Chronic Venous Insufficiency Physical Conditioning - Venous Insufficiency | Phase 2 | Completed | US Department of Veterans Affairs | 60 | 1999-01-01 | 2009-01-21 |
| Antistax® in Patients With Chronic Venous Insufficiency Antistax®, low dose, Antistax®, high dose, Placebo - Venous Insufficiency | Phase 2 | Completed | Boehringer Ingelheim | 260 | 1998-04-01 | 2014-07-16 |
Varicose Ulcer (4) · Leg Ulcer (3) · Bronchiolitis Obliterans Syndrome (2) · Postthrombotic Syndrome (2) · Diabetes Mellitus (1) · Diabetic Foot (1) · Foot Ulcer (1) · Hypertension (1) · Multiple Sclerosis (1) · Syndrome (1) · Venous Thrombosis (1)
Cardiovascular Diseases (19) · Vascular Diseases (19) · Skin Diseases (4) · Skin Ulcer (4) · Skin and Connective Tissue Diseases (4) · Varicose Veins (4) · Immune System Diseases (3) · Bronchial Diseases (2) · Bronchiolitis (2) · Bronchiolitis Obliterans (2) · Bronchitis (2) · Embolism and Thrombosis (2) · Endocrine System Diseases (2) · Graft vs Host Disease (2) · Lung Diseases (2)
Antistax (2) · Gelatin (2) · 3-methoxy-14,15-methyleneestra-1,3,5-triene-17-ol (1) · Exercise Therapy (1) · Gels (1) · Injections (1) · Lasers (1) · Rosuvastatin Calcium (1) · Sodium Tetradecyl Sulfate (1) · Standard of Care (1) · crisaborole (1) · thymosin beta(4) (1)
Boehringer Ingelheim (2) · Medical University of South Carolina (2) · University of Johannesburg (2) · ConvaTec Inc. (1) · EnzySurge (1) · Euromedic Specialist Clinics, Poland (1) · Hadassah Medical Organization (1) · Khanh Nguyen (1) · Ludwig Boltzmann Institute for Operative Laparoscopy (1) · Pfizer (1) · Queen's University (1) · RegeneRx Biopharmaceuticals, Inc. (1) · Regenera Pharma Ltd (1) · US Department of Veterans Affairs (1) · University Medicine Greifswald (1)
United States (6) · Israel (3) · Germany (2) · Poland (2) · South Africa (2) · Austria (1) · Canada (1) · Italy (1)
Radmila Razlog, M.TechHom (2) · Andrea Ladwig (1) · Andreas Shamiyeh (1) · Arie Bass, Prof. (1) · Connie Harris, MNSc (1) · Elizabeth A Nelson, PhD (1) · Elizabeth VanDenKerkhof, PhD (1) · Eran Tamir, Dr. (1) · Galia Spectre, MD (1) · Giorgio Guarnera, MD (1) · Ian D Graham, PhD (1) · John Fryer, Ph.D. Assistant Director (1) · Karen Lorimer, MNSc (1) · Khanh P Nguyen, MD (1) · Margaret B Harrison, PhD (1)
PMID 33141449, PMID 21995267, PMID 23031428, PMID 23388350, PMID 25703058, PMID 26719678, PMID 26888961, PMID 29489633, PMID 33735146, PMID 35507774, PMID 39313976
R01NR012237 (1)