88 completed, 15 unknown, 8 terminated, 2 active not recruiting. 44 Phase 3, 31 Not applicable, 25 Phase 4, 17 Phase 2, 9 Phase 1.
Follow fanasil, pyrimethamine drug combination: new trials by email Literature Review of fanasil, pyrimethamine drug combination trials Research Report on fanasil, pyrimethamine drug combination
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Perennial Malaria Chemoprevention in the Malaria Vaccine Era Sulfadoxine pyrimethamine + Amodiaquine, Dihydroartemisinin Piperaquine, Dihydroartemisinin Piperaquine Placebo - Malaria, Falciparum | Phase 4 | Not yet recruiting | Stanford University | 1290 | 2026-09-01 | 2026-01-07 |
| Parasite Clearance and Protection From Infection (PCPI) in Zambia SP (Macleods Pharmaceuticals Ltd), AS (Guilin Pharmaceuticals) - Malaria | Phase 3 | Completed | London School of Hygiene and Tropical Medicine | 600 | 2024-07-24 | 2025-03-12 |
| Effectiveness and Cost-effectiveness of Integrated Model for Malaria and Helminth Control Sulphadoxine-pyrimethamine and Amodiaquine - Malaria, Soil Transmitted Helminths | Not applicable | Unknown | London School of Hygiene and Tropical Medicine | 1200 | 2024-05-27 | 2024-03-20 |
| Eggs for Gut Health Whole egg powder, Corn powder, Supercereal Plus - Moderate Acute Malnutrition, Stunting | Not applicable | Completed | Washington University School of Medicine | 461 | 2023-10-09 | 2025-02-06 |
| Improving Cognition and Gestational Duration With Targeted Nutrition M-RUSF+ (Maternal Ready-to-Use Supplementary Food + DHA/EPA/choline), M-RUSF (Maternal Ready-to-Use Supplementary Food), Azithromycin - Malnutrition in Pregnancy, Preterm Birth | Not applicable | Active not recruiting | Washington University School of Medicine | 1660 | 2023-08-18 | 2026-03-02 |
| Perennial Malaria Chemoprevention (PMC) in Côte d'Ivoire Sulfadoxine pyrimethamine - Malaria, Anemia | Completed | London School of Hygiene and Tropical Medicine | 1381 | 2023-08-11 | 2026-09-08 | |
| Perennial Malaria Chemoprevention (PMC) in Cameroon Sulfadoxine pyrimethamine - Anemia, Malaria | Completed | London School of Hygiene and Tropical Medicine | 2138 | 2023-07-19 | 2026-09-08 | |
| Innovative Intermittent Preventive Treatment Approaches to Reduce Malaria Burden in School-age Children in Burkina Faso Sulphadoxine-Pyrimethamine/Amodiaquine, Dihydroartemisinin/Piperaquine (DP) plus Ivermectin (IVM) - Malaria | Phase 3 | Unknown | Malaria Consortium | 13000 | 2023-07-15 | 2023-11-22 |
| Comparing Chemoprevention Drugs for School-based Malaria Control Dihydroartemisinin-Piperaquine, Chloroquine, Sulfadoxine pyrimethamine - Malaria,Falciparum, Anemia in Children | Phase 4 | Completed | University of Maryland, Baltimore | 646 | 2023-02-13 | 2023-08-07 |
| Sulfadoxine-pyrimethamine Plus Dihydroartemisinin-piperaquine for Intermittent Preventive Treatment in Pregnancy Dihydroartemisinin-Piperaquine (DP), Sulfadoxine pyrimethamine (SP) - Malaria, Malaria in Pregnancy | Phase 3 | Active not recruiting | Menzies School of Health Research | 1172 | 2022-08-31 | 2025-06-06 |
| Controlled Human Malaria Infection Transmission Model - Phase A PfSPZ Challenge, Sulfadoxine-Pyrimethamine, Piperaquine - Malaria,Falciparum | Phase 1 / Phase 2 | Suspended | University of Oxford | 44 | 2022-08-22 | 2024-05-23 |
| Effectiveness, Feasibility and Acceptability of Seasonal Malaria Chemoprevention in Aweil South County in South Sudan Sulfadoxine pyrimethamine, Amodiaquine - Malaria | Phase 3 | Unknown | Malaria Consortium | 3575 | 2022-07-18 | 2024-03-25 |
| Chemoprevention Efficacy Study in Burkina Faso Sulfadoxine pyrimethamine, Amodiaquine - Malaria | Phase 4 | Unknown | Malaria Consortium | 800 | 2022-07-15 | 2023-11-01 |
| Feasibility and Safety of Combining Anti-malarial With Deworming Drugs in African Children Albendazole, Praziquantel, Amodiaquine - Malaria, Soil Transmitted Helminths | Not applicable | Unknown | London School of Hygiene and Tropical Medicine | 600 | 2022-06-16 | 2022-07-14 |
| Effectiveness and Chemoprevention Efficacy of Implementing Seasonal Malaria Chemoprevention in Karamoja Region, Uganda Sulfadoxine pyrimethamine and amodiaquine, dihydroartemisinin-piperaquine - Malaria | Phase 4 | Unknown | Malaria Consortium | 6805 | 2022-06-01 | 2023-11-01 |
| Effectiveness of Seasonal Malaria Chemoprevention in Nampula Province, Mozambique: Type Two Hybrid Implementation Study Chemopreventive Agent - SPAQ, Control Test - no drugs given - Malaria | Phase 4 | Unknown | Malaria Consortium | 3156 | 2022-01-08 | 2023-11-02 |
| Gametocytocidal and Transmission-blocking Efficacy of PQ in Combination With AL and TQ in Combination With SPAQ in Mali Artemether-lumefantrine, Primaquine Phosphate, Sulphadoxine-pyrimethamine with amodiaquine - Malaria,Falciparum | Phase 2 | Completed | London School of Hygiene and Tropical Medicine | 80 | 2021-10-12 | 2022-01-18 |
| Comparison of ISTp- PYRAMAX-US-RDT to IPTp-SP to Prevent Malaria in Pregnant Women in DRC (ULTRAPYRAPREG) Sulfadoxine pyrimethamine, Pyramax - Malaria in Pregnancy | Phase 3 | Completed | University of Kinshasa | 250 | 2021-05-06 | 2022-11-04 |
| Optimal Chemopreventive Regimens to Prevent Malaria and Improve Birth Outcomes in Uganda Sulfadoxine-pyrimethamine (SP), Dihydroartemisinin-piperaquine (DP) - Malaria | Phase 3 | Completed | Grant Dorsey, M.D, Ph.D. | 2757 | 2020-12-28 | 2025-11-06 |
| The ASPIRE Trial - Aiming for Safe Pregnancies by Reducing Malaria and Infections of the Reproductive Tract IPTp-sulphadoxine-pyrimethamine plus metronidazole, IPTp-dihydroartemisinin-piperaquine plus metronidazole, IPTp-sulphadoxine-pyrimethamine - Pregnancy Malaria, Bacterial Vaginoses | Phase 3 | Completed | London School of Hygiene and Tropical Medicine | 5436 | 2019-12-15 | 2023-05-22 |
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Malaria (87) · Malaria, Falciparum (22) · Anemia (13) · HIV Infections (5) · Malaria, Vivax (4) · Birth Weight (3) · HIV Seropositivity (3) · Schistosomiasis (3) · Acquired Immunodeficiency Syndrome (2) · Anemia, Sickle Cell (2) · Growth Disorders (2) · Premature Birth (2) · AIDS-Related Opportunistic Infections (1) · Autoimmune Diseases (1) · Autoimmune Lymphoproliferative Syndrome (1)
London School of Hygiene and Tropical Medicine (33) · Centers for Disease Control and Prevention (7) · Institute of Tropical Medicine, Belgium (5) · Malaria Consortium (5) · National Institute of Allergy and Infectious Diseases (NIAID) (5) · Hospital Clinic of Barcelona (4) · Washington University School of Medicine (4) · Pfizer (3) · Radboud University Medical Center (3) · University of California, San Francisco (3) · University of Cape Town (3) · University of Oxford (3) · Albert Schweitzer Hospital (2) · Grant Dorsey, M.D, Ph.D. (2) · Liverpool School of Tropical Medicine (2)
Mozambique (11) · Kenya (9) · Malawi (9) · Tanzania (9) · Uganda (9) · Burkina Faso (7) · Mali (7) · The Gambia (6) · Ghana (5) · Nigeria (5) · Zambia (5) · Gabon (4) · Papua New Guinea (4) · Senegal (4) · Benin (3)
Brian Greenwood, MD (4) · Mark J Manary, MD (4) · Paul J Milligan, PhD (4) · Badara Cisse, PhD (3) · Brian Greenwood, FRCP, FRS (3) · Clara Menendez, MD, PhD (3) · Karen Barnes, MBChB (3) · R Matthew Chico, MPH, PhD (3) · Alassane Dicko, MD (2) · Christine Manyando, MD (2) · Daniel Chandramohan, MBBS, PhD (2) · Frank Mosha, PhD (2) · Ghulam Rahim Awab, MD (2)
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P01HD059454 (1), R01AI104702 (1)