10 completed, 5 recruiting, 3 terminated, 2 withdrawn. 22 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 22 | Completed 10, Recruiting 5, Terminated 3, Withdrawn 2, Enrolling by invitation 1, Unknown 1 |
Follow Varicose Ulcer: new trials by email Literature Review of Varicose Ulcer trials Research Report on Varicose Ulcer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nonhealing Venous Leg Ulcers Treated With a Standard of Care (SoC) Alone or Standard of Care and Dehydrated Human Placenta Tissue (dHPT) With Crossover Amnion-Intermediate-Chorion, Standard of Care (SOC) - Venous Leg Ulcer (VLU) | Phase 4 | Enrolling by invitation | Cellution Biologics | 70 | 2026-02-04 | 2026-08-06 |
| A Non-Randomized Open Label Clinical Trial Evaluating DermaBind TL DermaBind TL - Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU) | Phase 4 | Completed | HealthTech Wound Care | 150 | 2025-12-10 | 2026-10-30 |
| COMS for Chronic Ulcers Treatment Concurrent optical and magnetic stimulation (COMS) treatment - Venous Leg Ulcer, Wound Heal | Phase 4 | Recruiting | Sebastian Probst | 122 | 2025-10-01 | 2026-05-08 |
| Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers Standard of Care DFU, Tri-Membrane Wrap™ DFU, Membrane Wrap™ DFU - Diabetic Foot, DFU | Phase 4 | Recruiting | BioLab Holdings | 650 | 2025-07-15 | 2025-07-28 |
| Trial to Evaluate Cyclical Topical Wound Oxygen Therapy in the Treatment of Chronic Venous Leg Ulcers Topical Wound Oxygen Therapy, Sham Control Topical Wound Oxygen - Venous Leg Ulcer (VLU) | Phase 4 | Recruiting | AOTI Ltd. | 212 | 2025-01-15 | 2025-11-19 |
| Evaluating Several Cellular, Acellular, and Matrix-like Products (CAMPs) and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot and Venous Leg Ulcers. ACApatch™, caregraFT™, Standard of Care - Venous Leg Ulcer, Venous Leg | Phase 4 | Recruiting | Tiger Biosciences, LLC. | 340 | 2024-12-06 | 2026-09-22 |
| Evaluating Intact Fish Skin Graft and Standard of Care Versus Standard of Care Alone in Nonhealing Venous Leg Ulcers Intact Fish Skin Graft (IFSG) + Standard of Care, Standard of Care - Venous Leg Ulcer (VLU), Venous Leg Ulcers | Phase 4 | Recruiting | Kerecis Ltd. | 150 | 2024-11-25 | 2025-01-24 |
| Study Evaluating Several CAMPs in Nonhealing Diabetic Foot and Venous Leg Ulcers Amnion-Intermediate-Chorion, Amnion-Chorion-Amnion, Standard of Care - Diabetic Foot Ulcer, Venous Leg Ulcer | Phase 4 | Completed | Cellution Biologics | 292 | 2024-10-14 | 2026-04-13 |
| Effectiveness of a Hydrophobic Dressing for Microorganisms' Colonization and Infection Control of Vascular Ulcers CUTIMED, AQUACEL silver - Venous Leg Ulcer, Bacterial Infections | Phase 4 | Unknown | University of Malaga | 204 | 2019-05-15 | 2020-03-25 |
| Effect of PEM Treatment of Superficial Axial and Tributary Vein Reflux on Improvement of Wound Healing in VLUs Polidocanol Endovenous Microfoam (PEM) - Leg Ulcer, Veins, Varicose | Phase 4 | Withdrawn | OhioHealth | 2017-04-10 | 2017-09-15 | |
| Amniotic Membrane Allograft Application in the Management of Venous Leg Ulcerations AmnioExCel dressing and compression therapy, SOC alginate dressing and compression therapy - Varicose Ulcer, Venous Insufficiency | Phase 4 | Terminated | Prisma Health-Upstate | 2 | 2017-02-15 | 2021-12-16 |
| Skin Ulcers Treatment With an Handicraft Topical Device drenovac handcrafted, Healing - Foot Ulcer, Varicose Ulcer | Phase 4 | Completed | Coordinación de Investigación en Salud, Mexico | 144 | 2014-03-01 | 2015-07-30 |
| Wound Fluid Protease Levels During Use of Novel Wound Dressing Novel Dressing - Venous Stasis Ulcers | Phase 4 | Completed | Hollister Incorporated | 35 | 2012-02-01 | 2016-11-25 |
| Restore Calcium Alginate Dressing, Silver vs Aquacel Ag in the Treatment of Critically Colonized Venous Leg Ulcers Restore Calcium Alginate Dressing, AquaCel Ag Wound Dressing - Venous Ulcer, Infection | Phase 4 | Terminated | Hollister Wound Care LLC | 19 | 2011-10-01 | 2013-02-15 |
| Clinical Trial to Evaluate the Efficacy, Tolerance and Acceptability of URGO Dressing vs a Hydrofibre in the Local Management of Venous or Predominantly Venous Mixed Leg Ulcers. Dressing - Varicose Ulcer | Phase 4 | Completed | Laboratoires URGO | 159 | 2011-05-01 | 2013-03-29 |
| A Post Marketing Study of Apligraf in Non-healing Wounds of Subjects With Venous Leg Ulcers Apligraf, Standard of Care Dressing Group - Venous Ulcer | Phase 4 | Completed | Organogenesis | 30 | 2011-03-01 | 2015-09-24 |
| Neuromuscular Electrical Therapy in Venous Ulcers neuromuscular electrical stimulation - Chronic Venous Insufficiency | Phase 4 | Completed | Faculdade Evangelica do Parana | 20 | 2011-02-01 | 2013-12-24 |
| Trial on the Efficacy of Prontosan Wound Irrigation Solution and Prontosan Wound Gel Prontosan Wound Irrigation Solution and Prontosan Wound Gel, Normal Saline and Placebo Gel - Venous Leg Ulcer | Phase 4 | Completed | B. Braun Ltd. Centre of Excellence Infection Control | 34 | 2009-10-01 | 2014-04-01 |
| A Post-Marketing Clinical Study of Apligraf for Venous Leg Ulcers Apligraf - Varicose Ulcer | Phase 4 | Withdrawn | Organogenesis | 2008-07-01 | 2015-08-19 | |
| OASIS Wound Matrix (Oasis) Mechanism of Action OASIS Wound Matrix - Diabetic Foot Ulcers (DFU), Venous Stasis Ulcers (VSU) | Phase 4 | Completed | Healthpoint | 13 | 2007-10-01 | 2011-06-09 |
Showing 20 of 22. Sign in to see all of them.
Diabetic Foot (7) · Leg Ulcer (5) · Ulcer (4) · Foot Ulcer (3) · Varicose Veins (2) · Bacterial Infections (1) · Gastroesophageal Reflux (1) · Infections (1) · Leg Injuries (1) · Pressure Ulcer (1) · Venous Insufficiency (1) · Wounds and Injuries (1)
Cardiovascular Diseases (22) · Skin Diseases (22) · Skin Ulcer (22) · Skin and Connective Tissue Diseases (22) · Vascular Diseases (22) · Varicose Veins (20) · Leg Ulcer (17) · Diabetes Complications (7) · Diabetes Mellitus (7) · Diabetic Angiopathies (7) · Diabetic Neuropathies (7) · Endocrine System Diseases (7) · Foot Ulcer (4) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4)
Standard of Care (4) · Bandages (1) · Compression Bandages (1) · Polidocanol (1) · Therapeutics (1) · cancer procoagulant (1)
Cellution Biologics (2) · Organogenesis (2) · AOTI Ltd. (1) · B. Braun Ltd. Centre of Excellence Infection Control (1) · BioLab Holdings (1) · Coordinación de Investigación en Salud, Mexico (1) · Faculdade Evangelica do Parana (1) · HealthTech Wound Care (1) · Healthpoint (1) · Hollister Incorporated (1) · Hollister Wound Care LLC (1) · Kerecis Ltd. (1) · Laboratoires URGO (1) · OhioHealth (1) · Prisma Health-Upstate (1)
United States (15) · France (2) · Austria (1) · Brazil (1) · Germany (1) · Spain (1) · Switzerland (1) · United Kingdom (1)
Anil Hingorani, MD (1) · Carl Van Gils, DPM, CWS (1) · Damien Bates, MD, PhD, FRACS (Plast.) (1) · Davin Haraway, DO (1) · Evangelos Badiavas, MD, PhD (1) · Fany Guadalupe Pat Espadas, MCs (1) · Ginger Salvadalena, PhD, RN (1) · Keith Harding, MD (1) · Korelo Raciele, M.sC (1) · Luis Sandoval Jurado, PhD (1) · Mike Griffiths, DProf, DMS, CRT, FCMI (1) · Raghu Kolluri, MD (1)
PMID 22990161, PMID 27822727, PMID 28053158, PMID 31674093, PMID 3893385, PMID 42366370