8 completed, 1 active not recruiting, 1 not yet recruiting, 1 terminated. 5 Phase 2, 3 Not applicable, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 4, Terminated 1 |
| Not applicable | 3 | Active not recruiting 1, Completed 1, Not yet recruiting 1 |
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Valve Surgery: new trials by email Literature Review of Valve Surgery trials Research Report on Valve Surgery
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Single Centre Study Comparing Continuous Interstitial Fluid Lactate Detection to Standard Measurements of Lactate in Patients Undergoing Elective Coronary Artery Bypass Graft Surgery and/or Valve Replacement. Continuous Lactate Monitoring Device - Coronary Artery Bypass, Coronary Artery Bypass Graft | Not applicable | Active not recruiting | Queen Mary University of London | 61 | 2025-05-20 | 2026-06-25 |
| Effect of Preoperative Sleep Intervention on Postoperative Delirium in Adult Patients Undergoing Cardiac Surgery Cognitive behavioral therapy intervention, Melatonin intervention, Placebo intervention - Delirium - Postoperative, Sleep Problems | Not applicable | Not yet recruiting | Yan Fuxia | 1281 | 2025-02-01 | 2025-01-15 |
| Observational Study to Investigate the Effects of Training on the Administration of Cardioplexol™ Cardioplegia Solution - Coronary Artery Bypass Surgery, Valve Surgery | Phase 3 | Completed | Swiss Cardio Technologies AG | 171 | 2018-11-20 | 2021-10-21 |
| Evaluating the Risk of Cognitive Impairment After Surgical and Transcatheter Aortic Valve Replacement Observational/Cognitive Assessment - Cardiovascular Disease, Aortic Valve Stenosis | Not applicable | Completed | Minnesota Veterans Medical Research and Education Foundation | 63 | 2016-05-01 | 2018-03-26 |
| An Trial of Two Dosing Regimens of AP214 for the Prevention of Kidney Injury in Patients Undergoing Cardiac Surgery AP214, Placebo - Cardiac Surgery, Coronary Artery Bypass | Phase 2 | Completed | Action Pharma A/S | 77 | 2010-10-01 | 2012-03-15 |
| Dexmedetomidine Medication Records and Delirium After Coronary Artery Bypass Grafting Dexmedetomidine, No dexmedetomidine medication record in the specified window - Delirium, Cardiac Surgical Procedures | Completed | China Medical University Hospital | 343112 | 2010-01-01 | 2026-09-11 | |
| Pharmacokinetics of AP214 Acetate in Patients Undergoing Cardiac Surgery AP214, Placebo - Cardiac Surgery, Coronary Artery Bypass Grafting | Phase 2 | Completed | Action Pharma A/S | 42 | 2009-05-01 | 2011-05-17 |
| Effect of Prime Solution on Fluid Balance After Open Heart Surgery HES, Ringer lactate - Valve Surgery, Coronary Artery Bypass Grafting | Phase 4 | Completed | University of Helsinki | 35 | 2009-01-01 | 2015-08-25 |
| Safety, Tolerability and Pharmacodynamics of AP214 Acetate in Patients Undergoing Cardiac Surgery AP214, Placebo - Cardiac Surgery, Coronary Artery Bypass Grafting | Phase 2 | Terminated | Action Pharma A/S | 75 | 2008-03-01 | 2009-06-01 |
| Effects of Deep Breathing Exercises Two Months After Cardiac Surgery Breathing exercises - CABG, Valve Surgery | Phase 2 | Completed | Uppsala University | 357 | 2007-09-01 | 2014-06-05 |
| Preoperative Ephedrine Attenuates the Hemodynamic Responses of Propofol During Valve Surgery: A Dose Dependent Study Ephedrine, Placebo, Phenylephrine - Hypotension, Valve Surgery | Phase 2 | Completed | King Faisal University | 150 | 2004-03-01 | 2020-09-02 |
Acute Kidney Injury (3) · Postoperative Complications (2) · Aortic Aneurysm (1) · Aortic Valve Stenosis (1) · Cardiovascular Diseases (1) · Delirium (1) · Emergence Delirium (1) · Hypotension (1) · Kidney Diseases (1) · Parasomnias (1)
Female Urogenital Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Male Urogenital Diseases (3) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Renal Insufficiency (3) · Urogenital Diseases (3) · Urologic Diseases (3) · Cardiovascular Diseases (2) · Confusion (2) · Kidney Diseases (2) · Mental Disorders (2) · Nervous System Diseases (2) · Neurobehavioral Manifestations (2) · Neurocognitive Disorders (2)
Breathing Exercises (1) · Cardioplegic Solutions (1) · Dexmedetomidine (1) · Ephedrine (1) · Phenylephrine (1) · Ringer's Lactate (1)
Action Pharma A/S (3) · China Medical University Hospital (1) · King Faisal University (1) · Minnesota Veterans Medical Research and Education Foundation (1) · Queen Mary University of London (1) · Swiss Cardio Technologies AG (1) · University of Helsinki (1) · Uppsala University (1) · Yan Fuxia (1)
Denmark (2) · United States (2) · Austria (1) · Egypt (1) · Finland (1) · Germany (1) · Saudi Arabia (1) · Sweden (1) · Taiwan (1) · United Kingdom (1)
Elisabeth Westerdahl, PhD, RPT (1) · En-Bo Wu, MD (1) · Howard Fink, MD (1) · Mohamed R El Tahan, M.D (1) · Prof Anthony Mathur (1) · Raili T Suojaranta-Ylinen, MD, PhD (1) · Santiago Garcia, MD (1) · Thomas M Beaver, MD, MPH (1)
PMID 24280904, PMID 24678691, PMID 40491721
2008 (1)