32 completed, 7 withdrawn, 6 terminated, 5 recruiting. 20 Phase 2, 19 Phase 1, 15 Not applicable, 1 Phase 3.
Follow Tongue Cancer: new trials by email Literature Review of Tongue Cancer trials Research Report on Tongue Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Surgeon-performed Ultrasound for Real-time Guidance In Oral Cancer Surgeries - A Multicenter Randomized Controlled Trial Ultrasound imaging, Standard Treatment - Tongue Cancer, Oral Cancer | Not applicable | Recruiting | Tobias Todsen | 150 | 2025-09-15 | 2026-05-13 |
| Normative Ranges of Lingual Strength and Endurance and the Impact of the IOPI Lingual Strength Trainer on Quantitative Functional Outcomes and Patient-Reported Outcomes After Partial Glossectomy or Hemiglossectomy for Oral Tongue Cancer, An Unblinded: Randomized Pilot Study Iowa Oral Performance Instrument (IOPI) - Tongue Cancer | Not applicable | Recruiting | Memorial Sloan Kettering Cancer Center | 60 | 2025-08-07 | 2026-06-30 |
| Anterolateral Thigh Myofascial Fat Composite Flap for Reconstruction of Hemiglossectomy Defects in Obese Patients With Tongue Cancer The anterolateral femoral myofascial fat composite flap (ALT-MF) repairs tongue defects in patients with tongue cancer - Tongue Cancer | Active not recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 35 | 2023-05-15 | 2026-07-06 | |
| Arabic PRO Measures for Head and Neck Cancer Radiotherapy. Radiation - Head and Neck Cancer, Head and Neck Neoplasms | Recruiting | King Saud University | 125 | 2023-05-01 | 2024-10-29 | |
| Surgical Margin Assessment by 3D Ultrasound 3D ultrasound - Tongue Cancer, Squamous Cell Carcinoma | Not applicable | Unknown | Copenhagen University Hospital, Rigshospitalet | 7 | 2023-01-01 | 2023-02-23 |
| The Registry of Oncology Outcomes Associated With Testing and Treatment Biomarker Testing (L), Systemic Treatment (T), Patient Reported Outcomes (P) - Adenocarcinoma, Adenocystic Carcinoma | Completed | Taproot Health | 167 | 2021-05-05 | 2024-12-18 | |
| Clinical Study Evaluating the Proper Surgical Safety Margin for Early Stage Oral Tongue Cancers 1.5 cm surgical safety margin for cT1-2N0 oral tongue cancers, 1.0 cm surgical safety margin for cT1-2N0 oral tongue cancers - Tongue Cancer, Tongue Cancer TNM Staging Primary Tumor (T) T1 | Not applicable | Terminated | Samsung Medical Center | 125 | 2021-01-18 | 2025-05-18 |
| Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S QBS10072S - Astrocytoma, Brain Cancer | Phase 1 | Completed | Quadriga Biosciences, Inc. | 15 | 2020-07-20 | 2023-01-18 |
| Oral Stent Device for Radiation Treatments of Oral Cancers CT Scan, Experimental Oral Stent Device - Tongue Tumor, Tongue Cancer | Withdrawn | Indiana University | 2019-09-25 | 2021-02-09 | ||
| Ultrasound in Tongue Cancer- a Help to Decide Depth of Invasion and to Improve the Surgical Margin Ultrasound - Tongue Cancer, Floor of Mouth Squamous Cell Carcinoma | Not applicable | Completed | Region Örebro County | 42 | 2019-05-28 | 2021-12-27 |
| Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene A166 - HER2-positive Breast Cancer, HER2 Gene Mutation | Phase 1 / Phase 2 | Completed | Klus Pharma Inc. | 49 | 2018-07-16 | 2023-08-03 |
| Radiotherapy of Tongue Cancer Using an Intraoral Stent Intraoral stent, No intraoral stent - Tongue Cancer | Phase 1 | Completed | Oslo University Hospital | 13 | 2018-03-09 | 2023-11-03 |
| Quality of Life in Patients Treated for Tongue and/or Jaw Neoplasia Before and After Speech Therapy Speech-language guidance, Speech therapy exercises for swallowing, Speech therapy exercises for speech - Tongue Cancer, Jaw Cancer | Not applicable | Completed | Hospital de Clinicas de Porto Alegre | 30 | 2018-03-01 | 2019-10-15 |
| Correlation of FAZA PET Hypoxia Imaging To 3D Histology in Oral Tongue Cancer (18)F-Fluoroazomycin arabinoside, Pimonidazole - Tongue Cancer | Phase 1 / Phase 2 | Suspended | Sunnybrook Health Sciences Centre | 10 | 2018-01-25 | 2024-08-12 |
| Prosthesis Guided Speech Rehabilitation of T1/T2 Cancers of the Tongue Palatal Augmentation Prosthesis (PAP), Articulation Therapy - Tongue Neoplasms, Tongue Cancer | Not applicable | Recruiting | University of Michigan | 40 | 2018-01-02 | 2026-05-08 |
| High-activity Natural Killer Immunotherapy for Small Metastases of Tongue Cancer High-activity natural killer - Tongue Cancer | Phase 1 / Phase 2 | Completed | Fuda Cancer Hospital, Guangzhou | 20 | 2016-12-01 | 2019-09-12 |
| Hypofractionated Radiation Therapy Followed by Surgery in Treating Patients With Advanced Squamous Cell Carcinoma of the Oral Cavity hypofractionated radiation therapy, intensity-modulated radiation therapy, therapeutic conventional surgery - Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity, Stage III Verrucous Carcinoma of the Oral Cavity | Not applicable | Withdrawn | Rutgers, The State University of New Jersey | 2016-08-01 | 2022-09-28 | |
| Cetuximab and Radiation Therapy in Treating Patients With Stage III-IV Head and Neck Cancer cetuximab, cisplatin, external beam radiation therapy - Stage III Squamous Cell Carcinoma of the Hypopharynx, Stage III Squamous Cell Carcinoma of the Larynx | Not applicable | Terminated | Rutgers, The State University of New Jersey | 8 | 2015-03-25 | 2021-04-21 |
| Circulating Tumor DNA in Predicting Outcomes in Patients With Stage IV Head and Neck Cancer or Stage III-IV Non-small Cell Lung Cancer Cytology specimen, Laboratory biomarker analysis - Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Salivary Gland Squamous Cell Carcinoma | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 130 | 2014-07-22 | 2025-05-15 | |
| Sorafenib Tosylate, Cisplatin, and Docetaxel in Treating Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck sorafenib tosylate, cisplatin, docetaxel - Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Recurrent Metastatic Squamous Neck Cancer With Occult Primary | Phase 1 | Completed | Ohio State University Comprehensive Cancer Center | 3 | 2014-04-14 | 2018-05-24 |
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Tongue Neoplasms (54) · Squamous Cell Carcinoma of Head and Neck (33) · Salivary Gland Neoplasms (22) · Mouth Neoplasms (13) · Head and Neck Neoplasms (7) · Carcinoma, Non-Small-Cell Lung (5) · Colonic Neoplasms (5) · Esthesioneuroblastoma, Olfactory (5) · Laryngeal Neoplasms (5) · Oropharyngeal Neoplasms (5) · Pancreatic Neoplasms (5) · Breast Neoplasms (4) · Rectal Neoplasms (4) · Stomach Neoplasms (4) · Bile Duct Neoplasms (3)
Mouth Diseases (54) · Neoplasms by Site (54) · Stomatognathic Diseases (54) · Tongue Diseases (54) · Neoplasms (51) · Head and Neck Neoplasms (47) · Mouth Neoplasms (41) · Neoplasms by Histologic Type (40) · Neoplasms, Glandular and Epithelial (40) · Carcinoma (39) · Carcinoma, Squamous Cell (32) · Salivary Gland Diseases (22) · Digestive System Diseases (10) · Gastrointestinal Diseases (10) · Respiratory Tract Diseases (10)
Cetuximab (8) · Cisplatin (4) · Erlotinib Hydrochloride (4) · Radiation (3) · Radiotherapy, Intensity-Modulated (3) · Sorafenib (3) · Biopsy (2) · Carboplatin (2) · Docetaxel (2) · Everolimus (2) · Radiotherapy (2) · Taxes (2) · Ultrasonography (2) · 1-phenyl-3,3-dimethyltriazene (1) · 130-nm albumin-bound paclitaxel (1)
National Cancer Institute (NCI) (13) · Ohio State University Comprehensive Cancer Center (5) · Fox Chase Cancer Center (3) · Roswell Park Cancer Institute (3) · University of Chicago (3) · Rutgers, The State University of New Jersey (2) · Copenhagen University Hospital, Rigshospitalet (1) · Fuda Cancer Hospital, Guangzhou (1) · Hospital de Clinicas de Porto Alegre (1) · Indiana University (1) · King Saud University (1) · Klus Pharma Inc. (1) · Marilyn Dodd (1) · Mayo Clinic (1) · Memorial Sloan Kettering Cancer Center (1)
United States (39) · China (3) · Denmark (2) · Sweden (2) · Australia (1) · Brazil (1) · Canada (1) · Italy (1) · Norway (1) · Saudi Arabia (1) · South Africa (1) · South Korea (1)
Anurag Singh (2) · Barbara Burtness (2) · Jill Gilbert (2) · Sung Kim (2) · Alexander Langerman (1) · Amit Agrawal (1) · Amit Agrawal, MD (1) · Christopher Thomas (1) · Einar Dale, MD PhD (1) · Enver Ozer, MD (1) · Floyd C. Holsinger (1) · Frank Meyskens (1) · Gary L. Clayman (1) · Han-Sin Jeong, MD PhD (1) · Hassan Arshad, MD (1)
PMID 14520092, PMID 23639862, PMID 25057165, PMID 25965900, PMID 26062933, PMID 26611425, PMID 26928328, PMID 29149611, PMID 30850872, PMID 31405750, PMID 35945244, PMID 36537851, PMID 40166973
P30CA072720 (2), U10CA021115 (2), U10CA032102 (2), N01CM00100 (1), N01CM62201 (1), N01CM62202 (1), N01CM62206 (1), P30CA006927 (1), P30CA014599 (1), P30CA015083 (1), P30CA015704 (1), P30CA016672 (1), P30CA068485 (1), P30CA076292 (1), P50CA097007 (1)