7 completed, 5 recruiting, 3 unknown, 2 enrolling by invitation. 11 Not applicable, 4 Phase 3, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 6, Unknown 3, Recruiting 1, Withdrawn 1 |
| Phase 3 | 4 | Recruiting 3, Not yet recruiting 1 |
| Phase 2 | 1 | Not yet recruiting 1 |
| Phase 4 | 1 | Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Machine Learning for Evaluating and Diagnosing Temporomandibular Disorders Low-Level Laser Acupuncture, Proprioceptive Training, Stabilization Splint Treatment - Temporomandibular Disorders (TMD), TMJ Disorder | Not applicable | Recruiting | En Chu Kong Hospital | 180 | 2026-10-09 | 2026-10-13 |
| Evaluation of the Effect of the Erchonia® EVRL on Chronic Jaw Pain Arising From TMJ Erchonia® EVRL™, Placebo Device - TMJ, TMJ Pain | Not applicable | Withdrawn | Erchonia Corporation | 2026-05-14 | 2026-09-23 | |
| Autologous Exosomes From Platelet-rich Plasma as a Modern Tool of Regenerative Dentistry Laboratory analysis of the content and biological activity of PRP, PRF, and exosomes obtained from blood samples - Temporomandibular Disorders (TMD), Muscle Pain | Enrolling by invitation | Wroclaw Medical University | 68 | 2026-05-01 | 2026-07-13 | |
| Biologic Augmentation of TMJ Arthroscopy Using BMAC Bone Marrow Aspirate Concentrate, Corticosteroid (CS) - TMJ - Oral &Maxillofacial Surgery, Oral and Maxillofacial Conditions | Phase 3 | Recruiting | Weill Medical College of Cornell University | 20 | 2026-05-01 | 2026-07-29 |
| Efficacy of Triamcinolone-Lidocaine Mix in Trigger Points Injection of Masseter Muscle: Double-blinded, Randomized Controlled Trial Saline, Triamcinolone with lidocaine, Lidocaine - TMJ Pain | Phase 2 / Phase 3 | Not yet recruiting | Cairo University | 30 | 2026-03-01 | 2026-03-03 |
| Bruxism and Pelvic Floor Dysfunction in Young Women Questionnaire and Physical Exam - Bruxism, Pelvic Floor Disorder | Enrolling by invitation | Akdeniz University | 100 | 2026-02-16 | 2026-03-12 | |
| Art-Based Pain Assessment Tool in Patients With Temporomandibular Joint Disorders Standard TMD Assessment, Artistic Pain Exploration (APE) Method - Temporomandibular Disorders (TMD), Wilkes 1 and 2 | Phase 3 | Recruiting | King Abdulaziz University | 70 | 2025-04-25 | 2025-06-15 |
| Nerve Block Treatment for Chronic Jaw Pain TMJ Pain | Recruiting | Bnai Zion Medical Center | 40 | 2025-04-25 | 2025-06-10 | |
| Comparison Between IPRF With Vit. C and IPRF Alone in Management of ID'Pain Vitamin C, Injectable platelet rich fibrin - TMJ Pain | Not applicable | Completed | Cairo University | 40 | 2024-04-15 | 2024-11-08 |
| Photobiomodulation on Pain in Patients With Temporomandibular Dysfunction Photobiomodulation using LED, Placebo - TMJ Pain | Not applicable | Completed | University of Nove de Julho | 32 | 2024-02-29 | 2026-07-29 |
| I-PRF After Arthrocentesis Plus Botox Injection to Lateral Pterygoid Muscle in Treatment of Anterior Disc Displacement TMJ Arthrocentesis Followed By Injectable Platelet Rich Fibrin And Botulinum Toxin Type A, TMJ Arthrocentesis Followed By Injectable Platelet Rich Fibrin, TMJ Arthrocentesis - TMJ Disc Disorder, TMJ Pain | Not applicable | Completed | Fayoum University | 39 | 2024-01-18 | 2026-09-01 |
| Arthrocentesis-PRF Versus Botulinum Toxin for Management of ADDwR Injectable Platelet-Rich Fibrin (I-PRF) Injection, Botulinum Toxin Type A (BOTOX) Injection - Temporomandibular Joint Internal Derangement, Temporomandibular Joint Disorders | Not applicable | Completed | Suez Canal University | 20 | 2024-01-10 | 2026-10-07 |
| Topical Treatment for TMJ Arthralgia Hydrocortisone 2.5%, Diclofenac 1% topical - TMJ Pain | Phase 3 | Recruiting | University of the Pacific | 90 | 2023-06-01 | 2024-12-11 |
| Clinical Efficacy of Polynucleotides TMJ Injections Compared to Physiotherapy. PoliArt - TMJ Disease, TMJ Pain | Not applicable | Completed | Sidoti & Tartaglia Srl | 60 | 2023-04-18 | 2024-05-07 |
| MDR-JuggerKnot Mini Soft Anchor in Maxillofacial TMJ JuggerKnot Mini Soft Anchor - TMJ Disc Disorder, TMJ Pain | Withdrawn | Zimmer Biomet | 2021-12-01 | 2022-01-27 | ||
| Arthrocentesis Followed by Prolotherapy joint lavage with dextrose - TMJ Pain | Not applicable | Unknown | Cairo University | 60 | 2020-01-08 | 2020-01-02 |
| Association of Jaw Dysfunction With Neck Disability in Subjects With Chronic Cervical Spine Disorders Musculoskeletal Pain, TMJ Pain | Completed | Horus University | 40 | 2019-06-01 | 2021-04-19 | |
| Effect of Manual Therapy on Jaw Movement and Function in Patients With Bruxism Deep friction massage, Pressure release, control group - Bruxism, TMJ Pain | Not applicable | Unknown | Cairo University | 120 | 2019-01-01 | 2018-11-27 |
| Accuracy and Efficacy of Trazodone (Desyrel) on Sleep Quality and Pain Management of TMD Patient polysomnography, Trazodone, Placebos - TMD, Sleep Bruxism | Phase 4 | Terminated | Centre hospitalier de l'Université de Montréal (CHUM) | 3 | 2018-10-15 | 2020-02-05 |
| RCT of a Temporomandibular Joint Distraction Device for Patients With Articular Disorders Diagnosis TMJ Condilar Distraction Device, Conventional Physical Therapy - TMJ Disc Disorder, TMJ Pain | Not applicable | Unknown | Fonseca, Julio | 40 | 2018-05-01 | 2018-11-13 |
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Temporomandibular Joint Disorders (9) · Bruxism (2) · Pain (2) · Arthralgia (1) · Chronic Pain (1) · Fibromyalgia (1) · Musculoskeletal Pain (1) · Myalgia (1) · Neck Pain (1) · Pelvic Floor Disorders (1) · Sleep Bruxism (1) · Sleep Wake Disorders (1)
Musculoskeletal Diseases (12) · Stomatognathic Diseases (12) · Muscular Diseases (11) · Joint Diseases (10) · Craniomandibular Disorders (9) · Jaw Diseases (9) · Mandibular Diseases (9) · Neurologic Manifestations (6) · Pathological Conditions, Signs and Symptoms (6) · Signs and Symptoms (6) · Pain (4) · Nervous System Diseases (3) · Tooth Diseases (3) · Behavior (2) · Habits (2)
Botulinum Toxins, Type A (2) · Acupressure (1) · Adrenal Cortex Hormones (1) · Arthrocentesis (1) · Ascorbic Acid (1) · Continuous Positive Airway Pressure (1) · Control Groups (1) · Diclofenac (1) · Glucose (1) · Injections (1) · Lidocaine (1) · Low-Level Light Therapy (1) · Occlusal Splints (1) · Physical Examination (1) · Polysomnography (1)
Cairo University (4) · Akdeniz University (1) · Bnai Zion Medical Center (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · En Chu Kong Hospital (1) · Erchonia Corporation (1) · Fayoum University (1) · Fonseca, Julio (1) · Horus University (1) · King Abdulaziz University (1) · Pomeranian Medical University Szczecin (1) · Sidoti & Tartaglia Srl (1) · Suez Canal University (1) · University of Nove de Julho (1) · University of the Pacific (1)
Egypt (4) · United States (3) · Brazil (1) · Canada (1) · Israel (1) · Italy (1) · Poland (1) · Portugal (1) · Saudi Arabia (1) · Taiwan (1) · Turkey (Türkiye) (1)
Ching-Mao Chang, MD, PhD (1) · Ching-Po Lin, PhD (1) · Edward Kijak, DSc (1) · Gianluca Tartaglia, MD (1) · Gilles Lavigne (1) · Gwendolyn Reeve, DMD (1) · Kacy Arnold (1) · Mohamed El-Sayed, Assistant lecturer (1) · Mohamed Said Hamed, Professor (1)
PMID 16331769, PMID 25822055, PMID 26696399, PMID 27044436, PMID 30210388, PMID 31353997, PMID 32086778, PMID 41792959