7 completed, 2 terminated, 1 recruiting. 10 Phase 2, 3 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 7, Terminated 2, Recruiting 1 |
| Phase 3 | 3 | Terminated 2, Completed 1 |
| Phase 1 | 1 | Completed 1 |
Follow Suicide, Attempted: new trials by email Literature Review of Suicide, Attempted trials Research Report on Suicide, Attempted
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| iTBS+D-Cycloserine for Youth Suicide D-Cycloserine, intermittent Theta-Burst-repetitive Transcranial Magnetic Stimulation, Placebo oral tablet - Suicidal Ideation, Suicide, Attempted | Phase 2 | Recruiting | University of Calgary | 54 | 2024-03-11 | 2024-11-12 |
| A Study to Evaluate the Safety and Effectiveness of a Digital Therapeutic OTX-202, OTX-000, Treatment as Usual - Suicide, Attempted, Suicidal Ideation | Phase 2 / Phase 3 | Terminated | Oui Therapeutics, Inc. | 356 | 2022-04-07 | 2025-06-12 |
| Sequential Therapy for the Treatment of Severe Bipolar Depression. NRX-101 Oral Capsule, Lurasidone Oral Capsule, Ketamine Intravenous Infusion - Bipolar Depression, Suicidal Ideas | Phase 2 | Completed | NeuroRx, Inc. | 22 | 2018-01-15 | 2021-05-25 |
| Aftercare Focus Study (AFS): A Clinical Trial to Reduce Short-Term Suicide Risk After Hospitalization Collaborative Assessment and Management of Suicidality, Treatment as Usual - Suicidal Ideation, Suicide, Attempted | Phase 2 | Completed | University of Washington | 150 | 2015-08-01 | 2021-01-05 |
| Lithium for Suicidal Behavior in Mood Disorders Lithium, Placebo - Depressive Disorder, Bipolar Disorder | Phase 2 / Phase 3 | Terminated | VA Office of Research and Development | 519 | 2015-07-08 | 2024-04-29 |
| miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment Outcome ketamine - Major Depressive Disorder | Phase 2 | Completed | University of Alabama at Birmingham | 247 | 2015-04-20 | 2022-08-30 |
| Effectiveness of a Family-Based Intervention for Adolescent Suicide Attempters (The SAFETY Study) SAFETY, Enhanced usual care - Suicide | Phase 1 / Phase 2 | Completed | University of California, Los Angeles | 72 | 2006-03-01 | 2025-03-30 |
| Treatment of Adolescent Suicide Attempters (TASA) fluoxetine, sertraline, citalopram - Depression, Suicide, Attempted | Phase 2 / Phase 3 | Completed | New York State Psychiatric Institute | 120 | 2004-03-01 | 2020-06-22 |
| Family Intervention for Suicidal Youth: Emergency Care FISP + Usual Care, Usual Care - Suicide, Attempted | Phase 2 | Completed | Centers for Disease Control and Prevention | 2003-10-01 | 2007-11-15 | |
| Youth-Nominated Support Team Intervention for Suicidal Adolescents Youth-Nominated Support Team - Suicide, Attempted | Phase 2 | Completed | University of Michigan | 448 | 2002-11-01 | 2013-11-11 |
Suicidal Ideation (5) · Depression (3) · Suicide (3) · Bipolar Disorder (2) · Anxiety Disorders (1) · Depressive Disorder (1) · Depressive Disorder, Major (1) · Dysthymic Disorder (1)
Behavior (10) · Behavioral Symptoms (10) · Self-Injurious Behavior (10) · Suicide (7) · Mental Disorders (5) · Mood Disorders (4) · Bipolar and Related Disorders (2) · Depressive Disorder (2)
Cycloserine (2) · Lithium (2) · Therapeutics (2) · Bupropion (1) · Citalopram (1) · Cognitive Behavioral Therapy (1) · Escitalopram (1) · Fluoxetine (1) · Ketamine (1) · Lurasidone Hydrochloride (1) · Mirtazapine (1) · Safety (1) · Sertraline (1) · Venlafaxine Hydrochloride (1) · interleukin-24 (1)
Centers for Disease Control and Prevention (1) · NeuroRx, Inc. (1) · New York State Psychiatric Institute (1) · Oui Therapeutics, Inc. (1) · University of Alabama at Birmingham (1) · University of Calgary (1) · University of California, Los Angeles (1) · University of Michigan (1) · University of Washington (1) · VA Office of Research and Development (1)
United States (8) · Canada (1)
Alexander McGirr, MD PhD (1) · Andrew Nierenberg, MD (1) · Cheryl A. King, Ph.D. (1) · Daniel C Javitt, MD (1) · Ira R Katz, MD PhD (1) · Joan R Asarnow, Ph.D. (1) · Joan R. Asarnow, PhD (1) · Katherine A Comtois, PhD, MPH (1) · Laurence Greenhill, MD (1) · Richard C Shelton, M.D. (1) · Yogesh Dwivedi, Ph.D. (1)
PMID 19730273, PMID 19730274, PMID 22211209, PMID 25255931, PMID 28545756, PMID 30725077, PMID 31350782, PMID 33677832, PMID 34787653, PMID 37573534, PMID 40779267
R01MH063881 (1), R01MH107183 (1), R34MH078082 (1), R42MH123357 (1), U10MH066750 (1), U10MH066762 (1), U10MH066769 (1), U10MH066775 (1), U10MH066778 (1)