240 completed, 58 recruiting, 46 unknown, 27 active not recruiting. 312 Not applicable, 27 Phase 2, 13 Phase 1, 13 Phase 4, 9 Phase 3.
Follow this condition Literature Review of Substance Use Disorders trials Research Report on Substance Use Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Medically Supervised Ibogaine With 12-Month Digital Recovery Support for Opioid Use Disorder Ibogaine Hydrochloride, Extended-release naltrexone injection, 380 mg, Matching Oral Placebo - Opioid Use Disorder, Opioid Withdrawal | Phase 1 / Phase 2 | Not yet recruiting | Clive Michelsen | 60 | 2027-07-01 | 2026-10-13 |
| Yuva Sath: A Peer-led Behavioral Intervention to Support Substance Use Treatment and HIV Prevention Among Young People Who Inject Drugs in India Yuva Sath - Hiv, Substance Use Disorders | Not applicable | Not yet recruiting | Massachusetts General Hospital | 60 | 2027-01-01 | 2025-10-22 |
| Co-Active Therapeutic Theatre (Co-ATT) for Dual-Diagnosis Patients Co-Active Therapeutic Theatre (Co-ATT) - Mental Health Issue, Substance Use Disorders | Not applicable | Suspended | Boston Medical Center | 10 | 2027-01-01 | 2026-04-02 |
| Clinical and Neurobehavioral Changes With Weight Loss Drug Discontinuation and Reinitiation Discontinuation and Reinitiation of Tirzepatide - Drug Discontinuation, Substance Use Disorders | Not applicable | Recruiting | The University of Texas at Dallas | 40 | 2026-10-01 | 2026-09-02 |
| Supporting Treatment Access and Recovery in Re-entry (STAR-R) Full MISSION-CJ, Peer Linkage Support - Mental Health, Substance Use Disorders | Not applicable | Not yet recruiting | University of Massachusetts, Worcester | 240 | 2026-10-01 | 2026-09-22 |
| Promoting Recovery by Overcoming Self-stigma in Mental Health Disorders With a Narrative Enhancement and Cognitive Therapy (NECT) Group Intervention Narrative Enhancement Cognitive Therapy, Control Group Sessions - Mental Disorders, Substance Use Disorders | Not applicable | Not yet recruiting | Louise Penzenstadler | 106 | 2026-10-01 | 2026-08-05 |
| Recovery Inspired Support Engagement (RISE) Pilot ITC - Support Persons, Family Members | Not applicable | Recruiting | Mclean Hospital | 18 | 2026-09-14 | 2026-09-15 |
| Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use Placebo, Oxycodone HCl, Kratom 8g - Opioid Use, Substance Use Disorders | Phase 1 | Recruiting | Christopher D. Verrico | 72 | 2026-09-01 | 2026-09-28 |
| Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder Psilocybin - Treatment Resistant Depression, Substance Use Disorders | Phase 1 / Phase 2 | Not yet recruiting | Indiana University | 50 | 2026-08-01 | 2026-03-30 |
| Interprofessional Simulation Program for Clinical Resilience and Empathy: Project INSPIRE INSPIRE - Substance Use Disorders, Simulation Training | Not applicable | Recruiting | University of Utah | 300 | 2026-08-01 | 2026-08-10 |
| Enhancing Addiction Treatment Through Psychoeducation Installing the Metacognium software app, Continue treatment as usual - Substance Use Disorders | Not applicable | Recruiting | Virginia Commonwealth University | 40 | 2026-07-23 | 2026-08-07 |
| Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic Substance Use Disorders, Alcohol Use Disorder | Recruiting | Boston University | 185810 | 2026-06-30 | 2026-07-02 | |
| Feasibility of an Interdisciplinary Intervention to Improve Care Transitions for Hospitalized Patients With Substance Use Disorders IntACT, Usual Care - Substance Use Disorders | Not applicable | Recruiting | Michael Incze | 75 | 2026-06-21 | 2026-08-10 |
| The Effect of Comorbid Alcohol/Substance Use case (comorbid diagnosis), control - Alcohol Abuse, Alcohol Use Disorder | Recruiting | Abant Izzet Baysal University | 297 | 2026-06-20 | 2026-07-13 | |
| Neuroimaging of Adolescent Cannabis Use Treatment Contingency Management, Elastic Net Regression - Cannabis Use, Cannabis Dependence | Not applicable | Recruiting | Indiana University | 80 | 2026-06-15 | 2026-06-22 |
| Effectiveness of Depression and Substance Use Module for Patients With Co-occurring Disorders Experimental Group: Treatment Module D-SUD-M, Control Group - Depression, Substance Use Disorders | Not applicable | Active not recruiting | International Islamic University, Islamabad | 50 | 2026-05-02 | 2026-07-16 |
| Peer-Delivered Behavioral Activation in a CCBHC Peer Activate, Peer-delivered non-specific services - Major Depressive Disorder, Substance Use Disorders | Not applicable | Recruiting | Wayne State University | 250 | 2026-05-01 | 2026-04-17 |
| Innovating Technology Solutions for Residents in Support Housing Communities w SUD Through Community-Engaged Research Technology-based Intervention - Housing Problems, Household Substance Abuse | Not applicable | Completed | Oregon Research Behavioral Intervention Strategies, Inc. | 15 | 2026-04-29 | 2026-07-13 |
| Prevent Language Delays and Disorders Among Children of Caregivers With Substance Use Disorders With Community Groups and Individualized Services Comilia Group, Interaction Review Enhancement, Practical Support Enhancement - Language Delay, Substance Use Disorders | Not applicable | Recruiting | University of Oregon | 244 | 2026-03-10 | 2026-10-13 |
| Efficacy of Digital Problem Solving Application in Reduction of Anxiety, Depression and Substance Use Disorder Symptoms DSPT - Digital Support for Problem-solving Therapy - Anxiety, Depressive Symptoms | Early Phase 1 | Not yet recruiting | 7 Generation Games | 100 | 2026-03-01 | 2024-04-04 |
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Substance-Related Disorders (417) · Alcoholism (41) · Opioid-Related Disorders (40) · Stress Disorders, Post-Traumatic (40) · Anxiety Disorders (27) · Behavior, Addictive (25) · Mental Disorders (22) · Acquired Immunodeficiency Syndrome (21) · Depression (21) · Bipolar Disorder (12) · Hepatitis C (12) · HIV Infections (11) · Psychological Well-Being (11) · Psychotic Disorders (11) · Schizophrenia (11)
Chemically-Induced Disorders (416) · Mental Disorders (395) · Behavior (114) · Infections (46) · Narcotic-Related Disorders (44) · RNA Virus Infections (43) · Virus Diseases (43) · Communicable Diseases (42) · Stress Disorders, Traumatic (41) · Trauma and Stressor Related Disorders (41) · Blood-Borne Infections (40) · Alcohol-Related Disorders (39) · Urogenital Diseases (33) · Immune System Diseases (32) · Genital Diseases (31)
Therapeutics (29) · Cognitive Behavioral Therapy (8) · Motivational Interviewing (7) · Crisis Intervention (5) · Standard of Care (5) · Educational Status (4) · Mass Screening (4) · Transcranial Direct Current Stimulation (4) · Control Groups (3) · Quetiapine Fumarate (3) · Surveys and Questionnaires (3) · Transcranial Magnetic Stimulation (3) · elbasvir-grazoprevir drug combination (3) · Behavior Therapy (2) · Counseling (2)
VA Office of Research and Development (11) · Indiana University (10) · Johns Hopkins University (10) · Medical University of South Carolina (10) · Centre for Addiction and Mental Health (9) · University of Wisconsin, Madison (7) · Yale University (7) · Massachusetts General Hospital (6) · University of California, Los Angeles (6) · Boston Medical Center (5) · Chestnut Health Systems (5) · Karolinska Institutet (5) · University of Pittsburgh (5) · Columbia University (4) · New York State Psychiatric Institute (4)
United States (278) · Canada (22) · Norway (15) · Sweden (10) · Germany (8) · France (7) · Turkey (Türkiye) (7) · Switzerland (6) · Egypt (5) · Spain (4) · Hong Kong (3) · Netherlands (3) · United Kingdom (3) · Mexico (2) · Pakistan (2)
Laurie A Zawertailo, PhD (3) · Michael L Dennis, Ph.D. (3) · Alene Kennedy-Hendricks, PhD (2) · Allison Lin, MD (2) · Brandon G Oberlin, PhD (2) · Christy K Scott, Ph.D. (2) · Constance Guille, MD (2) · David Smelson, PsyD (2) · Jessica F Magidson, PhD (2) · Madhukar Trivedi, MD (2) · Marc Rosen, MD (2) · Massimo di Giannantonio, MD (2) · Michael Kidorf, Ph.D. (2) · Oluwaseun Falade-Nwulia, MBBS, MPH (2)
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K23DA044321 (2), K23DA050808 (2), 1DP2DA042424-01 (1), 1RM1DA055437-01 (1), 1UG3AT009758-01 (1), 2023 (1), 2025 (1), 2UG1DA040316-06 (1), 4UH3AT009758-03 (1), 5IK2HX002612-02 (1), 5UG1DA050207 (1), 7UG3DA057042-03 (1), D43TW009345 (1), I21RX004083 (1), K01AA024796 (1)