214 completed, 34 unknown, 14 recruiting, 9 withdrawn. 161 Not applicable, 46 Phase 2, 38 Phase 1, 16 Phase 3, 13 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing a Mobile Health Application to Improve HIV Prevention and Substance Use Treatment Among Women Involved in the Carceral System Tool to provide re-entry support and improve linkage to healthcare and social services - Substance Abuse, HIV | Not applicable | Not yet recruiting | Temple University | 74 | 2026-10-20 | 2026-09-29 |
| Micropractices for Unhoused LGBTQ Youth Mindfulness and Identity-Based Micropractice, Control Condition Micropractice - Well-Being (Psychological Flourishing), Internalizing Mental Health Symptoms | Early Phase 1 | Not yet recruiting | Cornell University | 200 | 2026-10-01 | 2026-09-17 |
| Brief Intervention Addressing Stigma Among Parents of Children With Mental Health Problems Brief video - Depression Disorders, ADHD | Not applicable | Not yet recruiting | New York State Psychiatric Institute | 1600 | 2026-10-01 | 2026-09-03 |
| Youth Overdose & Use Reduction in Rural Systems Navigator - Flexible Care Management - Substance Abuse, Opioid Abuse (Disorder) | Not applicable | Not yet recruiting | Seattle Children's Hospital | 550 | 2026-10-01 | 2026-09-29 |
| Mobile Technology to Reduce Teen Substance Misuse WisePath for Teens, Peer Support Services (PSS), Control - Substance Use, Substance Abuse | Not applicable | Recruiting | Evidence-Based Practice Institute, Seattle, WA | 600 | 2026-08-18 | 2026-08-20 |
| Neuroimaging of Adolescent Cannabis Use Treatment Contingency Management, Elastic Net Regression - Cannabis Use, Cannabis Dependence | Not applicable | Recruiting | Indiana University | 80 | 2026-06-15 | 2026-06-22 |
| Hybrid Dialectical Behavior Therapy for Veterans to Further Reduce Emotion Regulation Problems and Trauma Symptoms Hybrid dialectical behavior therapy - PTSD, Emotion Regulation Disorders | Not applicable | Recruiting | Arkin | 24 | 2026-06-01 | 2026-06-17 |
| Comparison of the Italian and U.S. Forensic Models for Dual-diagnosis Offenders: a 3-year Longitudinal Study SCHIZOPHRENIA 1 (Disorder), Substance Abuse | Not yet recruiting | University of Bari | 600 | 2026-06-01 | 2026-05-14 | |
| The Trans-Led Care Study The TLC Program - Substance Abuse, Substance Addiction | Not applicable | Recruiting | Illinois Institute of Technology | 124 | 2026-04-14 | 2026-07-15 |
| Senyo Health With Substance Use Disorder (SUD) in Primary Care Senyo App, Follow-up - Substance Use Disorders, Substance Abuse | Not applicable | Enrolling by invitation | Mayo Clinic | 60 | 2025-09-22 | 2026-05-22 |
| Feasibility of Long-term, High-dose Stimulant for Methamphetamine Use Disorder LDX-01 plus TAU, Placebo plus TAU - Methamphetamine Abuse, Methamphetamine-dependence | Phase 2 | Recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 80 | 2025-07-18 | 2026-02-23 |
| SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Families SER Familia - Substance Abuse, Intimate Partner Violence (IPV) | Not applicable | Recruiting | Duke University | 400 | 2025-06-30 | 2026-10-16 |
| Exploring Substance Use, Sleep Disturbances and Reward Sensitivity Cognitive Behavioral Therapy for Insomnia, Sleep Education - Substance Abuse, Sleep Disturbances | Not applicable | Not yet recruiting | Kwai Chung Hospital | 154 | 2025-06-16 | 2025-06-24 |
| Health Surveillance at Constructor University Bremen (CUB) questionnaire - Social Isolation or Loneliness, Anxiety | Active not recruiting | Jacobs University Bremen gGmbH | 373 | 2025-03-17 | 2026-09-25 | |
| Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prevention Co-Design Sessions (CDS), Data products - Substance Abuse, Decision Making, Shared | Not applicable | Recruiting | Chestnut Health Systems | 341 | 2025-02-06 | 2026-03-16 |
| Harm Reduction Services Integrated Harm Reduction Intervention (IHRI) - Drug Use, Substance Abuse | Not applicable | Recruiting | NYU Langone Health | 200 | 2024-11-25 | 2026-08-20 |
| The STop UNhealthy Substance Use Now Trial Practice Facilitation (PF), Learning Collaborative (LC), Performance Incentives (PI) - Risky Health Behavior, Substance Use Disorders | Not applicable | Active not recruiting | Ohio State University | 144 | 2024-09-16 | 2026-03-25 |
| Nurse-Led Heart Math Training Program With Substance Use Disorder Nurse-Led Heart Math Training Program - Substance Abuse | Not applicable | Unknown | Alexandria University | 120 | 2024-07-01 | 2024-05-31 |
| "Effectiveness of School-based Substance Abuse Prevention Programme Among Adolescents . School-based Substance abuse Prevention Programme (SSPP) - Substance Abuse | Not applicable | Recruiting | Manipal College of Nursing | 210 | 2024-05-01 | 2024-03-19 |
| Project BrEAtHe: A Culturally Tailored MBSR Intervention for Young Adult Black Men self-guided mHealth app only, self-guided mHealth app + 'real-time' feedback - Alcohol Abuse, Substance Abuse | Not applicable | Terminated | UConn Health | 22 | 2023-09-27 | 2026-01-26 |
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Substance-Related Disorders (290) · Alcoholism (25) · Depression (21) · Anxiety Disorders (19) · Opioid-Related Disorders (19) · HIV Infections (17) · Acquired Immunodeficiency Syndrome (15) · Cocaine-Related Disorders (14) · Behavior, Addictive (13) · Marijuana Abuse (9) · Psychological Well-Being (9) · Psychotic Disorders (9) · Sexually Transmitted Diseases (9) · Stress Disorders, Post-Traumatic (9) · Mental Disorders (8)
Chemically-Induced Disorders (290) · Mental Disorders (282) · Behavior (89) · Infections (37) · Urogenital Diseases (35) · Communicable Diseases (34) · Genital Diseases (33) · Behavioral Symptoms (30) · RNA Virus Infections (30) · Virus Diseases (30) · Immune System Diseases (29) · Blood-Borne Infections (28) · Immunologic Deficiency Syndromes (27) · Lentivirus Infections (27) · Retroviridae Infections (27)
Therapeutics (18) · Sugars (13) · Motivational Interviewing (6) · Cognitive Behavioral Therapy (5) · Crisis Intervention (4) · Standard of Care (4) · Varenicline (4) · Buprenorphine (3) · Buprenorphine, Naloxone Drug Combination (3) · Patient Navigation (3) · Quetiapine Fumarate (3) · Risperidone (3) · Secondary Prevention (3) · Aripiprazole (2) · Atomoxetine Hydrochloride (2)
Yale University (17) · Baylor College of Medicine (14) · UConn Health (11) · Treatment Research Institute (9) · University of California, Los Angeles (9) · George Mason University (7) · National Institute on Drug Abuse (NIDA) (7) · New York State Psychiatric Institute (6) · Columbia University (5) · Ohio State University (5) · University of Washington (5) · Brown University (4) · Dartmouth-Hitchcock Medical Center (4) · National Health Promotion Associates, Inc. (4) · RTI International (4)
United States (227) · Canada (6) · Norway (5) · Netherlands (3) · Puerto Rico (3) · South Africa (3) · Sweden (3) · Taiwan (3) · Chile (2) · Finland (2) · France (2) · Germany (2) · Hong Kong (2) · United Kingdom (2) · Argentina (1)
Nancy Petry, Ph.D. (7) · Nancy M Petry, Ph.D. (6) · Felicia Browne, ScD (4) · Richard De La Garza, II, PhD (4) · June P Tangney, Ph.D. (3) · Natasha Slesnick, Ph.D. (3) · Steven Shoptaw, PhD (3) · T. John Winhusen, PhD (3) · Alan I Green, MD (2) · Allison Barlow, MA, MPH (2) · Carlos del Rio, M.D. (2) · David S Festinger, Ph.D. (2) · Edward V Nunes, MD (2) · Frederick L Altice, MD (2) · John Walkup, MD (2)
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P30DA023918 (3), P50DA009241 (3), P50DA018185 (3), P50DA018197 (3), R01DA014694 (3), UG1DA013732 (3), P50DA027841 (2), R01DA016855 (2), R01DA027134 (2), U10DA013720 (2), 1RC1DA028387 (1), 2025 (1), 5RC2DA028864 (1), I01RX001292 (1), K23DA023334 (1)