12 completed, 5 not yet recruiting, 5 recruiting, 4 unknown. 11 Not applicable, 2 Phase 2, 1 Early Phase 1, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 5, Unknown 3, Recruiting 2, Not yet recruiting 1 |
| Phase 2 | 2 | Completed 1, Recruiting 1 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 1 | 1 | Completed 1 |
Follow Splenic Diseases: new trials by email Literature Review of Splenic Diseases trials Research Report on Splenic Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Laparoscopic Hepatectomy Combined With Splenectomy on Hepatic Functional Reserve and Immune Function Liver Cirrhosis, HCC - Hepatocellular Carcinoma | Recruiting | Northern Jiangsu People's Hospital | 30 | 2026-08-02 | 2026-09-10 | |
| Effect of Laparoscopic Splenectomy on Lipid Profiles in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up) Cirrhosis, Splenectomy; Status | Not yet recruiting | Northern Jiangsu People's Hospital | 30 | 2026-05-01 | 2026-05-14 | |
| Effect of LSD on Lipid Profiles in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up) Cirrhosis, Liver, Splenectomy; Status | Not yet recruiting | Northern Jiangsu People's Hospital | 30 | 2026-05-01 | 2026-05-14 | |
| Effect of Laparoscopic Splenectomy on Renal Function in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up) Cirrhosis, Splenectomy; Status | Not yet recruiting | Northern Jiangsu People's Hospital | 30 | 2026-05-01 | 2026-05-18 | |
| Efficacy of Apixaban in Treating Portal Vein Thrombosis Occurring More Than One Year After LSD Apixaban 2.5 MG - Cirrhosis, Splenectomy | Not applicable | Recruiting | Northern Jiangsu People's Hospital | 20 | 2026-04-01 | 2026-03-31 |
| Vagus Nerve-guided Laparoscopic Splenectomy and Azygoportal Disconnection Vagus nerve-guided laparoscopic splenectomy and azygoportal disconnection - Cirrhosis, Hypersplenism | Not applicable | Recruiting | Northern Jiangsu People's Hospital | 15 | 2026-03-25 | 2026-04-01 |
| Liver Cirrhosis Complicated by Clinically Significant Portal Hypertension SonoVue - Portal Hypertension, Spleen Disease | Not applicable | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 107 | 2026-02-01 | 2026-01-26 |
| Hematological Disorders in EHPVO Patients No intervention (Observational Study) - Extrahepatic Portal Vein Obstruction (EHPVO), Thrombophilia | Not yet recruiting | Rahab Nady | 115 | 2025-08-01 | 2025-08-06 | |
| Study of the ITK Inhibitor Soquelitinib to Reduce Lymphoproliferation and Improve Cytopenias in Autoimmune Lymphoproliferative Syndrome (ALPS)-FAS Patients Soquelitinib - Autoimmune Lymphoproliferative Syndrome | Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 15 | 2025-03-10 | 2026-09-08 |
| AE05ML Device for ML Hem-o-lok Polymer Clip Delivery in Laparoscopic Surgical Procedures Observational Registery Study laparoscopic procedure - Gall Bladder Disease, Bile Duct Diseases | Completed | Teleflex | 161 | 2024-06-07 | 2026-05-11 | |
| Kosmos Anatomical Object Labeling and View Identification Pivotal Study Kosmos Anatomical Object Labeling and View Identification Algorithms - Cardiac Disorder, Hepatic Disorder | Not applicable | Completed | EchoNous Inc. | 32 | 2024-02-07 | 2024-06-21 |
| Effect of LSD on Lipid Profiles Within 1 Year Postoperatively in Cirrhosis Patients With Portal Hypertension Bleeding Lipid Profiles, Cirrhosis, Liver | Completed | Northern Jiangsu People's Hospital | 150 | 2022-05-01 | 2026-09-10 | |
| EUS-guided PSE in Combination With EUS-guided Treatment of Varices for Patients With Portal Hypertension coils, cyanoacrylate glue - Gastroesophageal Varices, Hypersplenism | Not applicable | Unknown | Tongji Hospital | 72 | 2021-01-05 | 2021-01-08 |
| Incentive Spirometry and Upper Abdominal Laparoscopic Surgery Volume-oriented incentive spirometry, Flow-oriented incentive spirometry - Cholecystitis, Perforated Duodenal Ulcer | Not applicable | Completed | Riphah International University | 60 | 2020-10-01 | 2021-10-20 |
| A Randomized Controlled Study on the Treatment of Cirrhosis Combined With Hypersplenism Endoscopic therapy+ beta blockers, Endoscopic therapy+ PSE+beta blockers, Endoscopic therapy - Liver Cirrhosis, Esophageal and Gastric Varices | Not applicable | Unknown | Qilu Hospital of Shandong University | 368 | 2020-09-25 | 2022-03-02 |
| Transfemoral Versus Transradial Partial Splenic Artery Embolization in Patients With Hypersplenism partial splenic artery embolization - Hypersplenism | Not applicable | Completed | Zagazig University | 112 | 2019-06-01 | 2022-07-06 |
| Hypersplenism in Patients With Liver Cirrhosis and Portal Hypertension Hypersplenism | Unknown | Assiut University | 400 | 2017-09-01 | 2017-09-01 | |
| The Treatment of Hepatocirrhosis and Portal Hypertension Endoscopic therapy+ beta blockers, Endoscopic therapy+ PSE+beta blockers, beta blockers - Hepatic Cirrhosis, Portal Hypertension | Not applicable | Completed | Yanjing Gao | 108 | 2016-02-01 | 2025-02-14 |
| Microwave Ablation and Partial Splenic Embolization in the Management of Hypersplenism Microwave Thermal Coagulation, Partial Splenic Embolization - Hypersplenism | Not applicable | Unknown | Tanta University | 40 | 2014-08-01 | 2014-10-10 |
| Enhancing Radioiodine (RAI) Incorporation Into BRAF Mutant, RAI-Refractory Thyroid Cancers With the BRAF Inhibitor Vemurafenib: A Pilot Study Vemurafenib, serial 124I PET/CT, thyrotropin alpha - Thyroid Carcinoma | Early Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 12 | 2014-05-20 | 2025-06-18 |
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Hypersplenism (17) · Hypertension, Portal (10) · Fibrosis (7) · Heterotaxy Syndrome (5) · Liver Cirrhosis (5) · Volvulus Of Midgut (3) · Autoimmune Lymphoproliferative Syndrome (2) · Heart Defects, Congenital (2) · Heart Diseases (2) · Splenomegaly (2) · Thrombocytopenia (2) · Abdominal Injuries (1) · Abnormalities, Multiple (1) · Anemia (1)
Hemic and Lymphatic Diseases (27) · Lymphatic Diseases (27) · Digestive System Diseases (14) · Pathological Conditions, Signs and Symptoms (13) · Liver Diseases (12) · Pathologic Processes (12) · Cardiovascular Diseases (6) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6) · Abnormalities, Multiple (4) · Cardiovascular Abnormalities (4) · Congenital Abnormalities (4) · Heart Diseases (4) · Autoimmune Diseases (3) · Fibrosis (3)
Adrenergic beta-Antagonists (1) · Blood Specimen Collection (1) · Laparoscopy (1) · MK 6 cyanoacrylate (1) · Observation (1) · Portasystemic Shunt, Transjugular Intrahepatic (1) · Thyrotropin Alfa (1) · Valproic Acid (1) · Vemurafenib (1) · apixaban (1) · contrast agent BR1 (1)
Northern Jiangsu People's Hospital (7) · Assiut University (1) · Boston Children's Hospital (1) · Children's Healthcare of Atlanta (1) · EchoNous Inc. (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Indiana University (1) · Insel Gruppe AG, University Hospital Bern (1) · Koneti Rao (1) · Memorial Sloan Kettering Cancer Center (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Qilu Hospital of Shandong University (1) · Rahab Nady (1) · Riphah International University (1) · Tanta University (1)
China (10) · United States (8) · Egypt (2) · Canada (1) · Pakistan (1) · Switzerland (1)
Guo-Qing Jiang, MD (5) · Abeer Fatima, MSPT-CPPT (1) · Alan L. Ho, MD, PhD (1) · Asad Karim, MD (1) · Asem A Elfert, MD (1) · Bin Cheng, Ph.D, M.D (1) · Dou-Sheng Bai (1) · Dou-Sheng Bai, MD (1) · Fabrizio Pizzolante (1) · Fat-heya E Assel, MD' (1) · Guo-Qing Jiang (1) · Islam S Ismail (1) · Koneti Rao, MD (1) · Lindsay Ryerson, MD (1) · Luc Defreyne, M.D., Ph.D (1)
PMID 107745, PMID 12239963, PMID 15246206, PMID 15625453, PMID 15674095, PMID 15862259, PMID 17377043, PMID 17943410, PMID 18412294, PMID 19070555, PMID 19380572, PMID 2071835, PMID 21343515, PMID 22021698, PMID 25741193, PMID 27703501, PMID 30256977, PMID 33638769, PMID 37486372, PMID 8340060, PMID 9124620