18 completed, 5 recruiting, 5 unknown, 4 terminated. 15 Phase 3, 9 Not applicable, 7 Phase 2, 5 Phase 1, 2 Phase 4.
Follow contrast agent BR1: new trials by email Literature Review of contrast agent BR1 trials Research Report on contrast agent BR1
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Liver Cirrhosis Complicated by Clinically Significant Portal Hypertension SonoVue - Portal Hypertension, Spleen Disease | Not applicable | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 107 | 2026-02-01 | 2026-01-26 |
| Contribution of Contrast Enhanced Ultrasound for Diagnosis of Adnexal Torsion Addition of ultrasound with contrast injection (SonoVue®), Standard Care (in control arm) - Adnexal Torsion | Phase 3 | Recruiting | Central Hospital, Nancy, France | 256 | 2025-05-14 | 2026-04-08 |
| Study of Placental Vascularization Using Contrast Ultrasound SonoVue - Fetal Growth Restriction | Phase 3 | Recruiting | Central Hospital, Nancy, France | 30 | 2025-04-09 | 2026-04-07 |
| A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients Bevacizumab, Microbubble, Low-Intensity Focused Ultrasound - Glioblastoma Multiforme, Glioblastoma | Phase 3 | Recruiting | NaviFUS Corporation | 32 | 2024-11-08 | 2026-04-09 |
| Safety and Efficacy of Bevacizumab in Combination With NaviFUS System for the Treatment of Recurrent Glioblastoma Multiforme (rGBM) NaviFUS System, Lumason, Bevacizumab - Glioblastoma Multiforme, Glioblastoma | Phase 1 / Phase 2 | Suspended | NaviFUS Corporation | 10 | 2024-10-22 | 2026-09-09 |
| Pediatric Intravenous Contrast-Enhanced Ultrasound(CEUS) in China contrast-enhanced ultrasound examination, SonoVue® - Abdominal Neoplasm, Abdominal Injury | Recruiting | The Children's Hospital of Zhejiang University School of Medicine | 108 | 2024-09-10 | 2025-12-08 | |
| Super-Resolution Ultrasound of the Brain in 3D Transtemporal ultrasound with contrast product (Sonovue) - Cerebral Stroke | Not applicable | Unknown | Assistance Publique - Hôpitaux de Paris | 20 | 2024-03-22 | 2024-09-19 |
| Neonatal Brain Ultrasound With CEUS and Elastography Brain contrast enhanced ultrasound, brain ultrasound elastography, Sulfur Hexafluoride - Neonatal Hypoxic Ischemic Encephalopathy, Neonatal Stroke | Phase 3 | Recruiting | Turku University Hospital | 100 | 2024-01-01 | 2026-01-15 |
| Preterm Neonates Brain Ultrasound With CEUS and Elastography Brain contrast enhanced ultrasound, brain ultrasound elastography, Sulfur Hexafluoride - Prematurity | Phase 3 | Withdrawn | Turku University Hospital | 2024-01-01 | 2026-01-15 | |
| Contrast Ultrasound for Pediatric Trauma - Comparative Evaluation (CAPTURE Study) Lumason - Abdominal Injury | Phase 1 / Phase 2 | Completed | David Mooney | 68 | 2021-05-10 | 2025-10-03 |
| Accuracy of Contrast-Enhanced Ultrasound for Hepatocellular Carcinoma Post TACE Lumason - Hepatocellular Carcinoma | Phase 4 | Completed | Milton S. Hershey Medical Center | 26 | 2020-10-14 | 2023-11-02 |
| Ultrasound-enhanced Uptake of Chemotherapy in Patients With Inoperable Pancreatic Ductal Adenocarcinoma SonoVue, Chemotherapy - Carcinoma, Pancreatic Ductal | Phase 2 | Completed | St. Olavs Hospital | 20 | 2020-02-10 | 2023-01-19 |
| Comparing SonoVue With Sonazoid Using CEUS-LIRADS in HCC Sonovue and Sonazoid, Sonazoid and Sonovue - Hepatocellular Carcinoma, Cirrhosis | Phase 3 | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 100 | 2019-06-30 | 2019-09-19 |
| Ultrasound-enhanced Delivery of Chemotherapy to Patients With Liver Metastasis From Breast- and Colorectal Cancer SonoVue, Focused Ultrasound - Colorectal Neoplasms, Breast Neoplasms | Phase 1 / Phase 2 | Completed | St. Olavs Hospital | 17 | 2018-11-12 | 2023-01-19 |
| Effectiveness of Contrast-Enhanced Ultrasound Contrast-Enhanced Ultrasound using Lumason - Abdominal Injuries, Physical Abuse | Phase 4 | Active not recruiting | Children's Hospital of Philadelphia | 120 | 2018-05-09 | 2025-12-24 |
| Contrast Enhanced Sonothrombolysis and Sonolysis in Stroke - a Swedish Study (CE-5S) SonoVue, Sodium chloride, Transcranial Ultrasound - Ischemic Stroke | Phase 3 | Terminated | Umeå University | 1 | 2017-11-28 | 2018-05-11 |
| Contrast-Enhanced Ultrasound in the Evaluation of Abdominal Injuries in Children Lumason - Abdominal Injury | Phase 1 / Phase 2 | Terminated | David Mooney | 74 | 2017-11-01 | 2021-06-11 |
| Multiparametric Ultrasound Imaging in Prostate Cancer SonoVue - Prostate Cancer, Prostatic Neoplasms | Not applicable | Unknown | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 200 | 2017-09-07 | 2019-01-17 |
| KVUS at Neoadjuvant CTx of Breast Cancer SonoVue - Early Primary Breast Cancer | Phase 3 | Unknown | RWTH Aachen University | 60 | 2016-12-12 | 2017-12-28 |
| HexafluOride, a Contrast Agent for Placenta Echo-angiography Contrast agent: SonoVue®. - Pregnancy | Phase 3 | Completed | Centre Hospitalier Régional Metz-Thionville | 55 | 2016-10-12 | 2026-06-24 |
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Abdominal Injuries (4) · Breast Neoplasms (3) · Coronary Artery Disease (3) · Neoplasms (3) · Brain Neoplasms (2) · Carcinoma, Hepatocellular (2) · Colorectal Neoplasms (2) · Fibrosis (2) · Glioblastoma (2) · Glioma (2) · Ischemic Stroke (2) · Neoplasms, Nerve Tissue (2) · Prostatic Neoplasms (2) · Abdominal Neoplasms (1) · Ascites (1)
Bracco Diagnostics, Inc (5) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Central Hospital, Nancy, France (2) · David Mooney (2) · NaviFUS Corporation (2) · RWTH Aachen University (2) · St. Olavs Hospital (2) · Turku University Hospital (2) · University Hospital, Tours (2) · Assistance Publique - Hôpitaux de Paris (1) · Centre Hospitalier Régional Metz-Thionville (1) · Children's Hospital of Philadelphia (1) · Enrico Ammirati (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · GE Healthcare (1)
United States (10) · France (7) · China (3) · Germany (3) · Canada (2) · Finland (2) · Italy (2) · Netherlands (2) · Norway (2) · Taiwan (2) · United Kingdom (2) · Belgium (1) · Denmark (1) · Israel (1) · South Korea (1)
David Mooney, MD, MPH (2) · Jussi Hirvonen (2) · Melda Dolan, MD (2) · Riitta Parkkola (2) · Tiina Laurikainen (2) · Vilhelmiina Parikka (2) · Alberto Spinazzi, M.D. (1) · Arne Solberg, PhD, MD (1) · Bertrand Napoleon, MD (1) · Diana Gaitini, Prof (1) · Elias Johansson, MD, PhD (1) · Elmar Stickeler, niv.-Prof. Dr. med. (1) · Enrico Ammirati, Doctor (1)
PMID 22562290, PMID 25754526, PMID 26777226, PMID 27751505, PMID 28858788, PMID 28874779, PMID 29432486, PMID 31101367, PMID 31511289, PMID 38401206, PMID 8372225
2008 (1), 2018 (1), 2019 (1), 2023 (1)