72 completed, 51 recruiting, 15 unknown, 12 terminated. 56 Not applicable, 23 Phase 2, 12 Phase 1, 8 Phase 3, 2 Phase 4.
Follow Hereditary Sensory and Motor Neuropathy: new trials by email Literature Review of Hereditary Sensory and Motor Neuropathy trials Research Report on Hereditary Sensory and Motor Neuropathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase I/IIa Trial of scAAV1.tMCK.NTF3 for Treatment of CMT1A scAAV1.tMCK.NTF3 - Charcot-Marie-Tooth Neuropathy Type 1A | Phase 1 / Phase 2 | Withdrawn | Nationwide Children's Hospital | 2027-04-01 | 2026-07-29 | |
| Muscle MRI Fat Fraction Before Surgery to Predict Strength Recovery After Foot-Drop Surgery in Charcot-Marie-Tooth Disease Tibialis posterior tendon transfer, Individualized adjunct procedures for cavovarus deformity correction, Ankle-foot orthosis (AFO) - Foot Drop, Charcot-Marie-Tooth Disease Type 1A | Not yet recruiting | Peking University Third Hospital | 100 | 2026-12-01 | 2026-10-26 | |
| Clinical, Electrophysiological and Genetic Characteristics of Hereditary and Inflammatory Polyneuropathies in France Genetic and Inflammatory Polyneuropathies | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 1000 | 2026-11-01 | 2026-10-01 | |
| Rare Disease Registry Database for Movement Disorders in Southern Anhui Province Motor Neuron Diseases, Spinocerebellar Ataxias | Recruiting | First Affiliated Hospital of Wannan Medical College | 180 | 2026-09-30 | 2026-10-23 | |
| Genotype/Phenotype Correlation of MORC2 Mutations Skin biopsy, Blood sample - Charcot Marie Tooth Disease, DIFGAN | Recruiting | Hospices Civils de Lyon | 45 | 2026-06-16 | 2026-06-18 | |
| Physical Activity Level at Home in CMT1A Patients: Wearable Sensor Assessment Charcot-Marie-Tooth Disease, Type IA, Peripheral Neuropathy Hereditary | Not yet recruiting | University Hospital, Limoges | 60 | 2026-06-01 | 2026-05-22 | |
| Ultrasound-Guided Nerve Hydrodissection for Diabetic Lower Limb Entrapment Neuropathy Ultrasound-guided nerve hydrodissection treatment, Sham treatment - Diabetic Peripheral Neuropathy, Entrapment Neuropathy | Not applicable | Recruiting | Chongqing Medical University | 266 | 2026-05-20 | 2026-06-17 |
| Kinesio Taping for Pain, Median Nerve Morphology, and Quality of Life in Patients With Carpal Tunnel Syndrome Kinesio Taping, Nerve and Tendon Gliding Exercises - Carpal Tunnel Syndrome, Median Nerve Compression | Not applicable | Completed | Istanbul Gelisim University | 40 | 2026-05-10 | 2026-08-03 |
| Neuromodulation to Enhance Motor Function in HSP transcutaneous spinal cord stimulation - Hereditary Spastic Paraplegia | Not applicable | Recruiting | Rahul Sachdeva | 15 | 2026-04-09 | 2026-04-22 |
| Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease Whole-body Electrical Muscle Stimulation Exercise - Neuromuscular Diseases (NMD), Amyotrophic Lateral Sclerosis | Not applicable | Recruiting | University of Missouri-Columbia | 50 | 2026-03-10 | 2026-03-17 |
| Assessment of a Portable Digital Device for Quantified Analysis of Markerless Walking in Volunteers With Neuromuscular Diseases or Asymptomatic Volunteers Gait analysis via video capture - Spinal Muscular Atrophy (SMA), Charcot-Marie-Tooth | Not applicable | Recruiting | Institut de Myologie, France | 30 | 2026-03-03 | 2026-11-03 |
| The Effectiveness of Low-Level Laser Therapy in the Treatment of Meralgia Paresthetica Transcutaneous Electrical Nerve Stimulation (TENS), Low-Level Laser Therapy - Meralgia Paresthetica, Lateral Femoral Cutaneous Nerve Entrapment | Not applicable | Completed | Istanbul Training and Research Hospital | 36 | 2026-03-02 | 2026-07-08 |
| Intraneural Administration of scAAV9/JeT-GAN Into the Vagus Nerve for Patients With Giant Axonal Neuropathy (GAN) scAAV9/JeT-GAN - Giant Axonal Neuropathy (GAN) | Phase 1 | Recruiting | University of Texas Southwestern Medical Center | 4 | 2026-03-01 | 2026-04-22 |
| Walking Function Outcomes Following Surgical Correction With Rehabilitation Versus Physical Therapy Alone in Charcot-Marie-Tooth Disease: A Bidirectional Cohort Study Functional Surgery plus Rehabilitation, Physical Exercise - Charcot Marie Tooth Disease (CMT), Pes Cavovarus | Not yet recruiting | Peking University Third Hospital | 200 | 2026-02-11 | 2026-02-25 | |
| High-Intensity Laser Therapy in Carpal Tunnel Syndrome: Clinical, Sonographic, and Electrophysiological Outcomes High-Intensity Laser Therapy (HILT), Sham High-Intensity Laser Therapy - Carpal Tunnel Syndrome | Not applicable | Recruiting | Ankara City Hospital Bilkent | 80 | 2025-11-02 | 2026-02-17 |
| Dental-Oral and Craniofacial Characteristics of Hereditary Spastic Paraplegia: A Preliminary Study Hereditary Spastic Paraplegia | Completed | University of Barcelona | 50 | 2025-10-15 | 2026-09-02 | |
| A First in Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of EDK060 in Adults With CMT1A. EDK060, dose A, EDK060, dose B, EDK060, dose C - Charcot-Marie-Tooth Disease, Type 1A | Phase 1 | Recruiting | Novartis Pharmaceuticals | 28 | 2025-09-30 | 2026-07-29 |
| Effects of Resistance Exercises in Hereditary Sensory-Motor Neuropathy (Charcot-Marie-Tooth Disease) Progressive Resistance Exercise Training - Polyneuropathy, Charcot Marie Tooth Disease (CMT) | Not applicable | Recruiting | Universidad de La Frontera | 22 | 2025-09-20 | 2025-09-23 |
| The Use of Assistive Gait Devices Can Reduce the Risk of Falls in Patients With Neuromuscular Diseases Following a Training Period. Assistive gait devices combined with physiotherapy - Inclusion Body Myositis, Myotonic Dystrophy 1 | Not applicable | Enrolling by invitation | LMU Klinikum | 30 | 2025-09-01 | 2025-07-18 |
| CMT Gait, Mobility, Balance - AOFAS Grant Ankle-foot Orthoses - Charcot Marie Tooth Disease (CMT) | Not applicable | Recruiting | Bopha Chrea | 66 | 2025-08-14 | 2025-09-23 |
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Charcot-Marie-Tooth Disease (112) · Spastic Paraplegia, Hereditary (49) · Neuromuscular Diseases (17) · Amyotrophic Lateral Sclerosis (11) · Motor Neuron Disease (11) · Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (11) · Carpal Tunnel Syndrome (10) · Muscular Atrophy, Spinal (10) · Peripheral Nervous System Diseases (9) · Muscle Spasticity (7) · Muscular Dystrophy, Facioscapulohumeral (7) · Adrenoleukodystrophy (6) · Alstrom Syndrome (6) · Median Neuropathy (6)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (170) · Congenital Abnormalities (169) · Nervous System Malformations (169) · Heredodegenerative Disorders, Nervous System (167) · Nervous System Diseases (167) · Genetic Diseases, Inborn (166) · Neurodegenerative Diseases (166) · Polyneuropathies (166) · Peripheral Nervous System Diseases (161) · Neuromuscular Diseases (153) · Pathological Conditions, Signs and Symptoms (49) · Central Nervous System Diseases (40) · Neurologic Manifestations (32) · Brain Diseases (30)
Exercise (3) · Physical Therapy Modalities (3) · Ascorbic Acid (2) · Blood Specimen Collection (2) · Hematologic Tests (2) · Rehabilitation (2) · Transcutaneous Electric Nerve Stimulation (2) · setmelanotide (2) · 4-Aminopyridine (1) · Atorvastatin (1) · Biotin (1) · Cannabidiol (1) · Chenodeoxycholic Acid (1) · Cycloserine (1) · Disease Vectors (1)
Assistance Publique - Hôpitaux de Paris (5) · IRCCS Eugenio Medea (5) · University Medical Center Goettingen (5) · National Institute of Neurological Disorders and Stroke (NINDS) (4) · Pharnext S.C.A. (4) · University of Iowa (4) · Ankara City Hospital Bilkent (3) · Assistance Publique Hopitaux De Marseille (3) · Boston Children's Hospital (3) · Centre Hospitalier Universitaire de Liege (3) · IRCCS Fondazione Stella Maris (3) · Peking University Third Hospital (3) · Shanghai 6th People's Hospital (3) · University Hospital Tuebingen (3) · University Hospital, Clermont-Ferrand (3)
United States (61) · France (30) · Italy (19) · Germany (17) · United Kingdom (13) · Canada (12) · Netherlands (10) · Turkey (Türkiye) (9) · China (8) · Spain (8) · Belgium (7) · Australia (4) · Denmark (4) · South Korea (4) · Cyprus (3)
Michael E Shy, MD (4) · A. Reghan Foley, M.D. (2) · Adeline Vanderver, MD (2) · David Herrmann, MBBCh (2) · Filippo M Santorelli, MD PhD (2) · Li Cao, phD (2) · Mark Roberts, MD (2) · Michael Benatar, MD, PhD (2) · Rudi Roumen, MD, PhD (2) · Shahram Attarian, MD (2) · Teresa Sevilla, MD (2) · Zarife Sahenk, MD., PhD. (2) · Aftab Ahmed Mirza Baig, DPT,MSAPT (1)
PMID 25519680, PMID 37395948, PMID 38507752, PMID 41491634, PMID 10411196, PMID 10540002, PMID 11232233, PMID 11382253, PMID 12235608, PMID 12671856, PMID 12851579, PMID 14564276, PMID 15610704, PMID 15680560, PMID 1577335, PMID 16267188, PMID 16849828, PMID 16900450, PMID 17030772, PMID 17210425, PMID 17364435, PMID 17709710, PMID 17980667, PMID 17986401, PMID 18312102, PMID 18455840, PMID 18843618, PMID 19084178, PMID 19181226, PMID 19457636, PMID 19479509, PMID 19703733, PMID 19774309, PMID 19782873, PMID 19833552, PMID 19909499, PMID 19922132, PMID 20595866, PMID 20850975, PMID 21254193, PMID 21694556, PMID 21706151, PMID 22003934, PMID 22475878, PMID 22507681, PMID 23182641, PMID 23421600, PMID 23797954, PMID 23806957, PMID 23944684
U54NS065712 (4), 2015 (2), U01TR001263 (2), U54NS092091 (2), 2018 (1), 2019 (1), 2025 (1), 5RC1NS068179-02 (1), R01HD113778 (1), R01NS072248 (1), T32GM007748 (1), U01NS106845 (1), U54NS064808 (1), U54NS115052 (1)