26 completed, 6 recruiting, 4 not yet recruiting, 3 terminated. 15 Not applicable, 5 Phase 2, 4 Phase 1, 3 Phase 4.
Follow Seizure: new trials by email Literature Review of Seizure trials Research Report on Seizure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Epileptiform Potential of Fully Immersive Virtual Reality Virtual Reality Headset, display off, Virtual Reality Headset, Display only, Virtual Reality Headset, Display and Hand Control - Epilepsy, Seizure | Not applicable | Not yet recruiting | Dartmouth-Hitchcock Medical Center | 40 | 2026-12-01 | 2026-08-27 |
| The TTM and ASM Trial Prophylactic ASM, Hypothermic, Normothermic - Critical Care Medicine, Emergency Medical Services | Phase 1 | Not yet recruiting | National Taiwan University Hospital | 100 | 2026-09-17 | 2026-10-07 |
| AI-Based Mobile Intervention on Medication Non-Adherence and Transition Medilepsy® Chatbot AI-Enhanced, Medilepsy® Chatbot Standard - Epilepsy, Seizure | Not applicable | Recruiting | University of Central Florida | 200 | 2026-05-01 | 2026-05-29 |
| Predictors of Drug Resistant Epilepsy Among Pediatric Patients Epilepsy, Seizure | Not yet recruiting | Assiut University | 200 | 2025-12-29 | 2025-12-17 | |
| A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures RAP-219 - Focal Epilepsy, Epilepsy | Phase 2 | Recruiting | Rapport Therapeutics Inc. | 30 | 2025-12-15 | 2026-01-23 |
| Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN) No Intervention: Observational Cohort - Baker Gordon Syndrome, Rare Neurodevelopmental Conditions | Recruiting | University of Missouri-Columbia | 100 | 2025-12-04 | 2026-01-09 | |
| Late-Onset Seizures: Trial of Vascular Risk Investigation and Treatment Vascuar risk factor screening (blood pressure, medical history, BMI, laboratory tests) - Epilepsy, Seizure | Recruiting | Sahlgrenska University Hospital | 420 | 2025-09-01 | 2026-03-03 | |
| Levetiracetam Versus Phenobarbital in Benzodiazepines Unresponsive Paediatric Prolonged Seizures Levetiracetam IV, Phenobarbital - Seizure | Not applicable | Recruiting | Ministry of Health and Sports, Myanmar | 180 | 2025-07-22 | 2025-08-01 |
| Assessment of Pre Hospital Rescue Intervention for Seizure in Pediatric Patients Seizure | Not yet recruiting | Assiut University | 50 | 2025-01-01 | 2024-12-09 | |
| Efficacy of Low Glycemic Index Diet Versus Classic Ketogenic Diet in Pediatric Epilepsy Treatment Low Glycemic index therapy, Classic Ketogenic Diet - Seizure, Epilepsy | Not applicable | Completed | Mashhad University of Medical Sciences | 40 | 2024-12-05 | 2025-08-05 |
| Pro-Epileptic Effects of IV Ketamine Ketamine, Midazolam, Propofol - Epilepsy, Seizure | Phase 4 | Completed | Haseki Training and Research Hospital | 300 | 2024-12-01 | 2025-12-15 |
| A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy NaviFUS System - Drug Resistant Epilepsy, Epilepsy | Phase 1 / Phase 2 | Recruiting | NaviFUS Corporation | 8 | 2024-09-13 | 2026-09-15 |
| An Observational Study of the NeuroBell EEG Monitor NeuroBell EEG Monitor - EEG, Neonatology | Completed | University College Cork | 17 | 2024-09-02 | 2026-04-02 | |
| Procedural Motor Memory in Long COVID-19 keypresses - Infectious Metabolic Encephalopathy, Ischemic Stroke | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 333 | 2021-11-15 | 2025-03-30 | |
| NaviFUS™ System Neuromodulating Treatment for Patients With Drug Resistant Epilepsy NaviFUS System - Drug Resistant Epilepsy, Seizure | Not applicable | Completed | NaviFUS Corporation | 12 | 2021-10-07 | 2026-04-09 |
| Effect of VR-ESMEPP on Parents' Seizure Management Virtual Reality - Virtual Reality, Epilepsy | Not applicable | Completed | Akdeniz University | 91 | 2018-08-06 | 2022-08-15 |
| Impact of Ketogenic Diets on Cardiovascular Health in Adults With Epilepsy Modified Atkins or Ketogenic Diet - Hypercholesterolemia, Carotid Intimal Medial Thickness 1 | Active not recruiting | Johns Hopkins University | 105 | 2016-03-01 | 2026-09-08 | |
| Lactate Compared to Creatine Kinase as Diagnostic Marker in Generalized Epileptic Seizure Serum lactate and CK concentrations in blood samples - Seizure, Syncope | Completed | RWTH Aachen University | 85 | 2015-11-01 | 2016-10-07 | |
| 1 Week Versus 6 Weeks of Levetiracetam in Surgical Brain Tumor Patients Levetiracetam - Brain Neoplasms, Brain Cancer | Phase 4 | Completed | University of Florida | 81 | 2015-08-05 | 2021-12-15 |
| Medium Chain Triglycerides as an Adjunct to the Modified Atkins Diet for Women With Catamenial Epilepsy betaquik® - Epilepsy, Seizure | Not applicable | Completed | Johns Hopkins University | 16 | 2015-03-01 | 2020-04-15 |
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Seizures (42) · Epilepsy (20) · Drug Resistant Epilepsy (4) · Brain Neoplasms (3) · Status Epilepticus (3) · Astrocytoma (2) · Central Nervous System Neoplasms (2) · Glioma (2) · Heart Arrest (2) · Malaria, Cerebral (2) · Oligodendroglioma (2) · Asthma (1) · Autistic Disorder (1) · Behavior (1) · Cardiovascular Diseases (1)
Nervous System Diseases (42) · Neurologic Manifestations (42) · Pathological Conditions, Signs and Symptoms (42) · Signs and Symptoms (42) · Brain Diseases (27) · Central Nervous System Diseases (27) · Cardiovascular Diseases (6) · Infections (4) · Neoplasms (4) · Vascular Diseases (4) · Central Nervous System Infections (3) · Cerebrovascular Disorders (3) · Heart Diseases (3) · Neoplasms by Site (3) · Nervous System Neoplasms (3)
Levetiracetam (7) · Diet, Ketogenic (2) · Fluid Therapy (2) · Blood Pressure (1) · Blood Specimen Collection (1) · Body Mass Index (1) · Circulatory Arrest, Deep Hypothermia Induced (1) · Health Records, Personal (1) · Health Services Needs and Demand (1) · Ketamine (1) · Magnetic Resonance Spectroscopy (1) · Mental Status and Dementia Tests (1) · Midazolam (1) · Neuropsychological Tests (1) · Phenobarbital (1)
Johns Hopkins University (4) · Assiut University (2) · NaviFUS Corporation (2) · University of Rochester (2) · Akdeniz University (1) · AstraZeneca (1) · Child Advocacy International (1) · Dartmouth-Hitchcock Medical Center (1) · Dr Andrea Rossetti (1) · ElectroCore INC (1) · Emory University (1) · Epicall LTD (1) · Haseki Training and Research Hospital (1) · Hôpital Armand Trousseau (1) · Kaohsiung Medical University Chung-Ho Memorial Hospital (1)
United States (15) · Taiwan (4) · Canada (2) · France (2) · Malawi (2) · Turkey (Türkiye) (2) · Australia (1) · Burma (1) · Finland (1) · Germany (1) · Iran (1) · Ireland (1) · Israel (1) · Pakistan (1) · Spain (1)
Gretchen L Birbeck, M.D. (2) · Aditya S Pandey, MD (1) · Ali Choucair (1) · Andrea O. Rossetti, MD (1) · Brian Walsh, MD (1) · Eli Heyman, Dr (1) · Esa Mervaala, MD, PhD,professor (1) · Gaetano Morelli, M.D. (1) · Hsiao-Feng Chou, M.D. (1) · Ian Stiell, MD (1) · Imran Quraishi, MD (1) · Jared E Quast, MD (1) · Jeffrey J. Raizer, MD (1)
PMID 31672143, PMID 10660394, PMID 16401617, PMID 16894099, PMID 22271699, PMID 23352199, PMID 24410973, PMID 24934501, PMID 28557750, PMID 29722352, PMID 29870458, PMID 29945898, PMID 31871217, PMID 32540959, PMID 33487129, PMID 33957739, PMID 37363462, PMID 38237090, PMID 38293492, PMID 39564442
R01NS074409 (2), R01NS038455 (1), U10CA037422 (1)