43 completed, 13 unknown, 10 recruiting, 6 terminated. 79 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 79 | Completed 43, Unknown 13, Recruiting 10, Terminated 6, Not yet recruiting 3, Active not recruiting 2, Enrolling by invitation 1, Withdrawn 1 |
Follow Scleroderma, Diffuse: new trials by email Literature Review of Scleroderma, Diffuse trials Research Report on Scleroderma, Diffuse
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Home-based Exercise for Improving Health-related Quality of Life in Systemic Sclerosis Home-based exercise programme, Usual Care - Systemic Sclerosis (SSc) | Not applicable | Not yet recruiting | University of Aarhus | 270 | 2026-10-15 | 2026-09-25 |
| Personalized Online Occupational Therapy Intervention for Adults With Scleroderma Personalized Online Occupational Therapy Intervention, Usual Care - Scleroderma, Scleroderma (Limited and Diffuse) | Not applicable | Completed | Universidad de Zaragoza | 24 | 2026-05-16 | 2026-10-14 |
| The Effect of Progressive Muscle Relaxation Exercises on Fatigue, Dyspnea, and Respiratory Function in Patients With Systemic Sclerosis Progressive Muscle Relaxation Exercise - Systemic Sclerosis (SSc) | Not applicable | Recruiting | University of Gaziantep | 50 | 2026-04-25 | 2026-10-08 |
| Clinical Study of EVM18001 in the Treatment of Refractory Autoimmune Diseases EVM18001 Injection - System Lupus Erythematosus(SLE), Scleroderma | Not applicable | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 12 | 2026-03-12 | 2026-03-13 |
| Evaluating Tools to Communicate Scleroderma Research Results to Patients - Trial #1 Plain-language summary, Dissemination Tool (Infographic) - Scleroderma, Systemic Sclerosis | Not applicable | Completed | Lady Davis Institute | 511 | 2025-12-05 | 2026-09-10 |
| Investigating the Effectiveness of the Biopsychosocial Model-Based Exercise Approach in Children and Adults Diagnosed With Scleroderma Cognitive Exercise Therapy Approach, Control group - Scleroderma, Scleroderma, Localized | Not applicable | Recruiting | Hacettepe University | 48 | 2025-12-04 | 2025-12-18 |
| Diffuse Cutaneous Scleroderma (DSSc) SFDI Study Spatial-frequency domain imaging (SFDI) - Systemic Scleroderma, Diffuse Cutaneous Scleroderma | Not applicable | Recruiting | Boston University | 65 | 2025-11-06 | 2026-07-23 |
| Pathogenic Mechanisms Involved in the Initiation and Progression of Systemic Sclerosis cutaneous biospy - Scleroderma (Limited and Diffuse) | Not applicable | Not yet recruiting | Université Catholique de Louvain | 15 | 2025-06-01 | 2025-06-11 |
| RENEW-AI: Personalizing Scleroderma Management With an AI Health Coach RENEW-AI - Scleroderma | Not applicable | Completed | University of Michigan | 20 | 2025-05-19 | 2025-08-20 |
| Study of Diosmin for the Treatment of Digital Ulcers in Systemic Sclerosis Diosmin, Placebo - Scleroderma, Systemic, Digital Ulcer | Not applicable | Recruiting | Primus Pharmaceuticals | 45 | 2025-05-02 | 2026-09-11 |
| Brain Boost Program to Improve Cognitive Function in People With Systemic Sclerosis Brain Boost group, Waitlist group - Scleroderma | Not applicable | Active not recruiting | University of Michigan | 66 | 2025-04-16 | 2026-04-28 |
| Evaluating the Effect of Questionnaire Context on the Reporting of Somatic Items Among People With Systemic Sclerosis Reordered PHQ-8 - Scleroderma, Systemic Sclerosis (SSc) | Not applicable | Completed | Lady Davis Institute | 851 | 2025-01-17 | 2025-09-09 |
| The Apollo Device in Systemic Sclerosis for the Management of fatiguE, Raynaud Phenomenon and qualiTy of Life Apollo Neuro Device, Sham device - Systemic Sclerosis (SSc) | Not applicable | Recruiting | Robyn T. Domsic, MD, MPH | 160 | 2025-01-06 | 2026-01-08 |
| Respiratory Muscle Training in Scleroderma Inspiratory muscle training, Exercise - Scleroderma (Limited and Diffuse) | Not applicable | Not yet recruiting | Firat University | 30 | 2024-11-10 | 2024-11-12 |
| Periodontal Microbiota in Systemic Sclerosis Subgingival dental plaque sampling for whole metagenome sequencing of the periodontal microbiota - Scleroderma Systemic | Not applicable | Recruiting | University Hospital, Strasbourg, France | 30 | 2024-10-24 | 2026-08-19 |
| TENS in Scleroderma Transcutaneous Electrical Nerve Stimulation - Scleroderma, Gastroparesis | Not applicable | Completed | University of Michigan | 11 | 2024-10-01 | 2026-08-13 |
| Skeletal Muscle Function in Interstitial Lung Disease Hyperoxia - Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis | Not applicable | Recruiting | University of British Columbia | 40 | 2024-08-07 | 2026-05-15 |
| Development and Evaluation of an Evidence-based Education Program for People With Hand Dysfunction in Scleroderma patient education program - Scleroderma, Systemic | Not applicable | Active not recruiting | Wen-Shao Lin | 40 | 2024-07-30 | 2024-11-20 |
| Connective Tissue Massage in Scleroderma Connective tissue massage, Exercise - Scleroderma | Not applicable | Unknown | Firat University | 30 | 2024-06-21 | 2024-06-26 |
| Self-management Telehealth Program for Scleroderma self-management program, Video guide and usual education, Telephone notification, video guide and usual education - Scleroderma | Not applicable | Completed | Khon Kaen University | 72 | 2023-10-11 | 2025-05-30 |
Showing 20 of 79. Sign in to see all of them.
Scleroderma, Systemic (43) · Motor Activity (7) · Raynaud Disease (4) · Fatigue (3) · Scleroderma, Localized (3) · Ulcer (3) · digital ulcers (3) · Anxiety Disorders (2) · Arthritis (2) · Autoimmune Diseases (2) · Cicatrix (2) · Depression (2) · Dyspnea (2) · Gastroparesis (2)
Skin Diseases (79) · Skin and Connective Tissue Diseases (79) · Connective Tissue Diseases (78) · Scleroderma, Systemic (36) · Pathological Conditions, Signs and Symptoms (15) · Behavior (10) · Pathologic Processes (9) · Cardiovascular Diseases (6) · Signs and Symptoms (6) · Vascular Diseases (6) · Immune System Diseases (5) · Musculoskeletal Diseases (5) · Respiratory Tract Diseases (5) · Embolism and Thrombosis (4) · Fibrosis (4)
Blood Specimen Collection (3) · Exercise (2) · Rehabilitation (2) · Biopsy (1) · Botulinum Toxins, Type A (1) · Cognitive Behavioral Therapy (1) · Control Groups (1) · Diosmin (1) · Endoscopy (1) · Endoscopy, Digestive System (1) · Extracorporeal Shockwave Therapy (1) · Gastroscopy (1) · Immunoglobulins, Intravenous (1) · Infusions, Intravenous (1) · Laser Therapy (1)
Lady Davis Institute (9) · University of Michigan (9) · Istanbul University (6) · University Hospital, Strasbourg, France (4) · Assistance Publique - Hôpitaux de Paris (3) · Assiut University (2) · Firat University (2) · Johns Hopkins University (2) · Pamukkale University (2) · Asociación Española de Esclerodermia (1) · Boston University (1) · Centro Universitário Augusto Motta (1) · Cukurova University (1) · Cytori Therapeutics (1) · Emirhan Karakuş (1)
United States (22) · Turkey (Türkiye) (14) · Canada (11) · France (11) · Spain (3) · Brazil (2) · China (1) · Denmark (1) · Egypt (1) · Germany (1) · Indonesia (1) · Italy (1) · Sweden (1) · Taiwan (1) · Thailand (1)
Brett D Thombs, PhD (2) · Brett Thombs, PhD (2) · Luc Mouthon, MD, PhD (2) · Susan Murphy (2) · Andreea Bujor, MD, PhD (1) · Ayse Ayan, Dr (1) · Bertolo B Manoel, MD,PhD (1) · Chris Derk, MD, MSc (1) · Dana DiRenzo, MD (1) · David Launay, MD,PhD (1)
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R01AR085317 (1)