10 completed, 4 unknown, 2 withdrawn. 16 Phase 1, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 16 | Completed 10, Unknown 4, Withdrawn 2 |
| Phase 2 | 6 | Completed 4, Unknown 1, Withdrawn 1 |
Follow Sars-CoV2: new trials by email Literature Review of Sars-CoV2 trials Research Report on Sars-CoV2
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of mTOR Inhibition With Sirolimus (RAPA) in Patients With COVID-19 to Moderate the Progression of ARDS Rapamycin, Placebo - Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Respiratory Failure | Phase 1 / Phase 2 | Withdrawn | The University of Texas Health Science Center at San Antonio | 2021-04-01 | 2021-06-01 | |
| Mesenchymal Stromal Cells for the Treatment of SARS-CoV-2 Induced Acute Respiratory Failure (COVID-19 Disease) Mesenchymal Stromal Cells, Supportive Care - Sars-CoV2, Acute Respiratory Distress Syndrome | Phase 1 / Phase 2 | Completed | Baylor College of Medicine | 28 | 2021-02-12 | 2026-10-21 |
| Trial of Combination Therapy to Treat COVID-19 Infection Ivermectin, Doxycycline Hcl, Zinc - COVID, Covid-19 | Phase 1 | Completed | ProgenaBiome | 31 | 2020-12-09 | 2024-09-24 |
| Efficacy of Subcutaneous Ivermectin With or Without Zinc in COVID-19 Patients Ivermectin Injectable Solution, Injectable Placebo, Zinc - Coronavirus Infection, COVID | Phase 1 / Phase 2 | Unknown | Sohaib Ashraf | 180 | 2020-11-14 | 2021-02-17 |
| Defibrotide Therapy for SARS-CoV2 (COVID-19) Acute Respiratory Distress Syndrome (ARDS) Defibrotide - COVID, Sars-CoV2 | Phase 1 | Completed | Gregory Yanik | 13 | 2020-10-01 | 2023-05-09 |
| Safety, Tolerability, and Pharmacokinetics of SAB-185 in Ambulatory Participants With COVID-19 SAB-185, Normal Saline - COVID-19, SARS-CoV2 | Phase 1 | Unknown | SAb Biotherapeutics, Inc. | 21 | 2020-08-20 | 2021-10-26 |
| Safety and Feasibility of Allogenic MSC in the Treatment of COVID-19 Mesenchymal Stromal Cells infusion - COVID-19, Sars-CoV2 | Phase 1 | Unknown | Hospital de Clinicas de Porto Alegre | 10 | 2020-07-25 | 2020-07-10 |
| A Study on the Safety, Tolerability and Immune Response of SARS-CoV-2 Sclamp (COVID-19) Vaccine in Healthy Adults MF59 adjuvanted SARS-CoV-2 Sclamp vaccine 5mcg, MF59 adjuvanted SARS-CoV-2 Sclamp vaccine 15mcg, MF59 adjuvanted SARS-CoV-2 Sclamp vaccine 45mcg - SARS-CoV2, Covid19 | Phase 1 | Completed | The University of Queensland | 216 | 2020-07-13 | 2024-05-02 |
| A Study of TL-895 With Standard Available Treatment Versus Standard Available Treatment for the Treatment of COVID-19 in Patients With Cancer TL-895 - COVID-19, Sars-CoV2 | Phase 1 | Completed | Telios Pharma, Inc. | 7 | 2020-07-09 | 2021-05-12 |
| Administration of Allogenic UC-MSCs as Adjuvant Therapy for Critically-Ill COVID-19 Patients Oseltamivir, Azithromycin, Umbilical Cord Mesenchymal Stem Cells - COVID, Pulmonary Infection | Phase 1 | Unknown | Universitas Indonesia | 40 | 2020-07-01 | 2020-07-07 |
| Safety, Tolerability, and Pharmacokinetics of SAB-185 in Healthy Participants SAB-185, Normal saline - COVID-19, SARS-CoV2 | Phase 1 | Completed | SAb Biotherapeutics, Inc. | 28 | 2020-07-01 | 2022-07-01 |
| A Study of APL-9 in Adults With Mild to Moderate ARDS Due to COVID-19 APL-9, Vehicle Control - COVID, Covid-19 | Phase 1 / Phase 2 | Completed | Apellis Pharmaceuticals, Inc. | 72 | 2020-05-28 | 2022-03-23 |
| Treatment of Covid-19 Associated Pneumonia With Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells Allogenic pooled olfactory mucosa-derived mesenchymal stem cells, Standard treatment according to the Clinical protocols - COVID, Covid-19 | Phase 1 / Phase 2 | Completed | Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus | 32 | 2020-05-11 | 2021-08-23 |
| Progesterone for the Treatment of COVID-19 in Hospitalized Men Progesterone 100 MG - COVID-19, Sars-CoV2 | Phase 1 | Completed | Sara Ghandehari | 40 | 2020-04-27 | 2021-01-27 |
| Clinical Trial to Assess the Safety and Efficacy of Intravenous Administration of Allogeneic Adult Mesenchymal Stem Cells of Expanded Adipose Tissue in Patients With Severe Pneumonia Due to COVID-19 ALLOGENEIC AND EXPANDED ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELLS - Sars-CoV2 | Phase 1 / Phase 2 | Completed | Andalusian Network for Design and Translation of Advanced Therapies | 26 | 2020-04-27 | 2022-04-06 |
| A Study of ResCure™ to Treat COVID-19 Infection ResCure™ - COVID, Covid-19 | Phase 1 | Withdrawn | ProgenaBiome | 2020-01-01 | 2021-04-08 |
COVID-19 (14) · Coronavirus Infections (5) · Respiratory Distress Syndrome (4) · Acute Lung Injury (2) · Respiratory Insufficiency (2) · Severe Acute Respiratory Syndrome (2) · Carcinoma (1) · Hematologic Neoplasms (1) · Lung Diseases, Interstitial (1) · Neoplasms (1) · Pneumonia (1) · Pneumonia, Viral (1)
Coronaviridae Infections (14) · Infections (14) · Lung Diseases (14) · Nidovirales Infections (14) · RNA Virus Infections (14) · Respiratory Tract Diseases (14) · Respiratory Tract Infections (14) · Virus Diseases (14) · Pneumonia (13) · Pneumonia, Viral (13) · Coronavirus Infections (9) · Respiration Disorders (4) · Lung Injury (2) · Hematologic Diseases (1) · Hemic and Lymphatic Diseases (1)
Saline Solution (3) · Ivermectin (2) · SAB-185 (2) · Zinc (2) · Ascorbic Acid (1) · Azithromycin (1) · Cholecalciferol (1) · Doxycycline (1) · Oseltamivir (1) · Palliative Care (1) · Progesterone (1) · Sirolimus (1) · Solutions (1) · Zinc Sulfate (1) · defibrotide (1)
ProgenaBiome (2) · SAb Biotherapeutics, Inc. (2) · Andalusian Network for Design and Translation of Advanced Therapies (1) · Apellis Pharmaceuticals, Inc. (1) · Baylor College of Medicine (1) · Gregory Yanik (1) · Hospital de Clinicas de Porto Alegre (1) · Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus (1) · Sara Ghandehari (1) · Sohaib Ashraf (1) · Telios Pharma, Inc. (1) · The University of Queensland (1) · The University of Texas Health Science Center at San Antonio (1) · Universitas Indonesia (1)
United States (10) · Australia (1) · Belarus (1) · Brazil (1) · Indonesia (1) · Pakistan (1) · Spain (1)
David Hoover, MD (2) · Sabine Hazan, MD (2) · Andrei Y Hancharou, Dr. (1) · Dean L Kellogg, MD, PhD (1) · Eduard A Dotsenko, Dr., prof. (1) · Gregory Yanik, MD (1) · Helen Heslop, MD (1) · Ismail H Dilogo, MD, PhD (1) · LaQuisa Hill, MD (1) · Lucia Silla, MD, PhD (1) · Moneeb Ashraf, MBBS (1) · Muhammad Ashraf, PhD (1) · Natalia G Antonevich, Dr. (1) · Paul Griffin, Dr (1) · Sara Ghandehari, MD (1)
PMID 33621601, PMID 33887208, PMID 34473343, PMID 34488858, PMID 35135310, PMID 35413279, PMID 37865043, PMID 39702045