25 completed, 9 recruiting, 5 unknown, 4 not yet recruiting. 38 Not applicable, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 38 | Completed 19, Recruiting 7, Not yet recruiting 4, Unknown 4, Enrolling by invitation 2, Active not recruiting 1, Terminated 1 |
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pilot Study of Sensor-Informed Smartphone-based Mental Health Interventions for Mood in Early Psychosis Smartphone-based Mindfulness Exercise, Smartphone-based Psychoeducation, Neutral Control Message - Psychosis, Anxiety | Not applicable | Not yet recruiting | Mclean Hospital | 10 | 2027-01-15 | 2026-10-05 |
| Metacognitive Bibliotherapy for Anxiety, Depression, and Metacognitions in University Students The Art of Letting Go - How to Stop Rumination | Book 1, Anchored | Book 2 - Anxiety, Depression | Not applicable | Not yet recruiting | Istanbul Nisantasi University | 110 | 2026-06-15 | 2026-06-04 |
| Optimization of Late Imagery Rescripting Research Using Generative Artificial Intelligence Imagery Rescripting Intervention - Generalized Anxiety, Fear of Failure | Not applicable | Recruiting | University of Social Sciences and Humanities, Warsaw | 40 | 2026-04-01 | 2026-05-07 |
| The Role of Rumination and Worry in Pain and Functional Limitation in Knee Osteoarthritis Osteo Arthritis Knee, Worries; Pain or Disability | Completed | Fatih Sultan Mehmet Training and Research Hospital | 103 | 2026-03-01 | 2026-09-01 | |
| Readiness and Progress in Emotion Regulation Therapy Emotion Regulation Therapy via Telehealth - Rumination, Worry | Not applicable | Recruiting | Teachers College, Columbia University | 36 | 2025-10-24 | 2026-10-20 |
| The Effect of Cognitive Behavioral Therapy (CBT)-Based Psychoeducation on Cognitive Flexibility and Rumination in the Elderly Cognitive Behavioral Approach-Based Psychoeducation Program - Cognitive Flexibility, Rumination | Not applicable | Not yet recruiting | Ataturk University | 38 | 2025-09-01 | 2025-09-04 |
| Modulation of Cortical Brain Activity During Attentional Control Positive sham neurofeedback, Negative sham neurofeedback, Control - Rumination, Chronic Pain | Recruiting | National Council of Scientific and Technical Research, Argentina | 35 | 2025-07-01 | 2025-09-25 | |
| Optimization of Imagery Rescripting Research Using Generative Artificial Intelligence Imagery Rescripting Intervention (AI-Generated) - Generalized Anxiety, Fear of Failure | Not applicable | Recruiting | University of Social Sciences and Humanities, Warsaw | 80 | 2025-06-01 | 2025-09-24 |
| Neurobiological Mechanisms of Pathological Rumination and Effects of Aripiprazole Escitalopram, Aripiprazole 5mg - Major Depressive Disorder (MDD), Rumination | Not applicable | Active not recruiting | Central South University | 108 | 2025-05-08 | 2026-06-12 |
| RCT Protocol for 'OverThinking': A Mobile EMI for Reducing Experiential Avoidance OverThinking - Depression, Anxiety | Not applicable | Not yet recruiting | University of Social Sciences and Humanities, Warsaw | 60 | 2025-05-01 | 2025-05-02 |
| Culturally Adapted i-CBT for Farsi/Dari Speaking Migrants Culturally adapted i-CBT - Depressive Symptoms, Anxiety Symptoms | Not applicable | Recruiting | Karolinska Institutet | 128 | 2025-03-25 | 2025-12-12 |
| Affirmation-Based Podcast Education for Fear of Childbirth and Rumination in Pregnant Women Affirmation-based podcast training - Fear of Childbirth, Rumination | Not applicable | Completed | Istinye University | 120 | 2025-02-14 | 2026-05-15 |
| Effect of Environment on the Central and Peripheral Nervous System Built environment, Natural environment - Rumination | Not applicable | Enrolling by invitation | University of South Florida | 95 | 2025-02-14 | 2025-03-25 |
| Neurobehavioral Affective Control Training Neurobehavioral Affective Control Training - Emotional Distress, Impulsive Behavior | Not applicable | Completed | University of California, Berkeley | 50 | 2024-11-22 | 2026-02-20 |
| Study on the Effectiveness of Journaling as an add-on to Cognitive Behavioral Therapy Journaling, Treatment as Usual (TAU) - Affective Disorders, Rumination | Not applicable | Enrolling by invitation | University Hospital Tuebingen | 80 | 2024-11-20 | 2026-04-08 |
| Barrett's Esophagitis in Anorexia Nervosa Binge/Purge Subtype EsoGuard - Barrett Esophagus, Anorexia Nervosa, Binge Eating/Purging Type | Recruiting | Denver Health and Hospital Authority | 25 | 2024-11-12 | 2025-12-10 | |
| The Effectiveness of Dialectical Behavior Therapy on Rumination and Cognitive Avoidance in Teachers Dialectical Behavior Therapy Skills Training - Rumination, Cognitive Avoidance | Not applicable | Completed | Islamic Azad University, Sanandaj | 34 | 2024-09-15 | 2026-06-16 |
| Mindfulness-Based fMRI Neurofeedback for Depression Mindfulness + fMRI Neurofeedback - Depression in Adolescence, Rumination | Not applicable | Recruiting | Columbia University | 90 | 2024-04-10 | 2026-04-29 |
| Can Rumination-Focused Cognitive Behavioral Therapy Reduce the Risk of Cardio-vascular Disease? Rumination-Focused Cognitive Behavior Therapy - Rumination, Depressive Symptoms | Not applicable | Completed | University of Louisville | 9 | 2023-08-15 | 2025-12-31 |
| Decoding and Modulating Affective Brain States Transcranial Magnetic Stimulation - Rumination, Major Depressive Disorder | Not applicable | Recruiting | University of Pennsylvania | 40 | 2023-02-21 | 2026-09-03 |
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Rumination Syndrome (47) · Depression (14) · Anxiety Disorders (11) · Depressive Disorder, Major (5) · Emotional Regulation (5) · Stress, Psychological (4) · Generalized Anxiety Disorder (3) · Sleep Initiation and Maintenance Disorders (3) · Affective Symptoms (2) · Chronic Pain (2) · Depressive Disorder (2) · Feeding and Eating Disorders (2) · Fibromyalgia (2) · Neoplasms (2) · Psychological Well-Being (2)
Digestive System Diseases (47) · Gastrointestinal Diseases (47) · Mental Disorders (46) · Feeding and Eating Disorders (45) · Behavior (21) · Behavioral Symptoms (20) · Pathological Conditions, Signs and Symptoms (9) · Mood Disorders (7) · Nervous System Diseases (7) · Signs and Symptoms (7) · Depressive Disorder (5) · Social Behavior (5) · Neurologic Manifestations (4) · Self-Control (4) · Dyssomnias (3)
Mindfulness (3) · Therapeutics (3) · Meditation (2) · Amyloid (1) · Aripiprazole (1) · Autogenic Training (1) · Baclofen (1) · Biofeedback, Psychology (1) · Built Environment (1) · Escitalopram (1) · Lactation (1) · Muscle Relaxation (1) · Professional Autonomy (1) · Relaxation Therapy (1) · Social Control, Formal (1)
University of Social Sciences and Humanities, Warsaw (3) · Claude Bernard University (2) · Columbia University (2) · Henry Ford Health System (2) · Karolinska Institutet (2) · Mclean Hospital (2) · Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey (2) · Teachers College, Columbia University (2) · University Hospital Tuebingen (2) · Ataturk University (1) · Central South University (1) · Centre Hospitalier Universitaire, Amiens (1) · Denver Health and Hospital Authority (1) · Fatih Sultan Mehmet Training and Research Hospital (1) · Happify Inc. (1)
United States (18) · Turkey (Türkiye) (6) · France (4) · United Kingdom (3) · Belgium (2) · Germany (2) · Israel (2) · Poland (2) · Sweden (2) · Argentina (1) · China (1) · Iran (1)
Ann-Christine Ehlis, Dr. (2) · Christopher L Drake, PhD (2) · Douglas S Mennin (2) · Allison Nitsch, MD (1) · Amit Bernstein, Ph.D. (1) · Dan J Edge, MRes (1) · Desmond Oathes, PhD (1) · Ed R Watkins, Professor (1) · Eliane Boucher, PhD (1) · Erez Nadir, MD (1) · Eric Serra, MD (1) · Erik M Andersson, PhD (1)
PMID 29206813, PMID 33871377, PMID 35054039, PMID 35436228, PMID 36279218, PMID 36457045, PMID 36622879, PMID 37839195, PMID 37848857, PMID 38534105, PMID 38551617, PMID 39137411, PMID 39970439, PMID 40424024, PMID 41426462, PMID 41702143
R01AG043463 (1), R61MH132072 (1)