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Barrett's Esophagitis in Anorexia Nervosa Binge/Purge Subtype

NCT06532734 — Recruiting, 25 participants, Denver Health and Hospital Authority

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Presence of Barrett's Esophagitis in a Cohort of People With Eating Disorders Who Engage in Purging Behaviors: A Pilot Study

RegistryNCT06532734
StatusRecruiting
Study typeObservational
Enrollment25 (Estimated)
SponsorDenver Health and Hospital Authority (Other); collaborators: Lucid Diagnostics, Inc.
ConditionsBarrett Esophagus, Anorexia Nervosa, Binge Eating/Purging Type, Rumination, Vomiting, Eating Disorders, Esophageal Adenocarcinoma
InterventionsEsoGuard (Device)
Datesstart 2024-11-12, primary completion 2026-11-01 (estimated), completion 2026-11-01 (estimated), first posted 2024-08-01, last updated 2025-12-10
Locations3 sites in United States

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-Summary

To better define the presence of Barrett's esophagus (BE) via non-endoscopic testing in an eating disorder cohort with purging (vomiting/rumination) behaviors

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+Detailed description

A prospective cohort study to assess the presence of BE in those with purging behaviors from their eating disorders has not been completed. There are multiple case reports describing a younger population not meeting typical screening guidelines whom developed this condition. To better define the presence of Barrett's esophagus (BE) via non-endoscopic testing in an eating disorder cohort with purging (vomiting/rumination) behaviors. Individuals with severe forms of eating disorders with purging and ruminating behaviors not meeting the current screening guidelines for BE will still test positive for BE.

+Arms and interventions

ArmTypeInterventionsDescription
AN-BPDevice: EsoGuardindividuals with a dx of AN-BP, with a >5-year history of purging, with a frequency of at least once a day.
  • EsoGuard (Device): device used to collect esophageal cell samples to test for the presence of abnormal cells which may indicate a dx of Barrett's esophagitis.

+Outcome measures

Primary outcomes

  • Number of patients positive for BE [12 months]: Individuals with severe forms of eating disorders with purging and ruminating behaviors not meeting a current screening guidelines for BE will test positive for BE

+Eligibility

Sex: All, ages: 18 Years to 65 Years

Inclusion Criteria:

* Patients diagnosed with an eating disorder diagnosis that includes purging history
* Ages 18-65
* Purging history =>5 years
* Purging or rumination at a minimum of once daily upon admission.
* Admission to the ACUTE Center for Eating Disorders and Severe Malnutrition

Exclusion Criteria:

* Any eating disorder diagnosis that does not include purging behaviors
* Ages under 18 and over 65
* Patients who otherwise meet the current ACG screening guidelines (chronic GERD and 3 or more risk factors for Barrett's mentioned in the Background)
* Received mandated care at time of enrollment
* Inability to consent to participate in the research

+Locations (3)

FacilityCityCountryStatus
ACUTE Center for Eating Disorders and Severe MalnutritionDenver, ColoradoUnited StatesRecruiting
Denver Health and Hospital AuthorityDenver, ColoradoUnited StatesRecruiting
Denver Health and Hospital AuthorityDenver, ColoradoUnited StatesRecruiting

+Investigators

My Notes