10 completed, 4 unknown, 2 recruiting, 2 terminated. 6 Phase 2, 2 Not applicable, 2 Phase 4, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 4, Terminated 1, Withdrawn 1 |
| Not applicable | 2 | Completed 2 |
| Phase 4 | 2 | Completed 2 |
| Phase 3 | 1 | Unknown 1 |
Follow Renal Osteodystrophy: new trials by email Literature Review of Renal Osteodystrophy trials Research Report on Renal Osteodystrophy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Precision Medicine Approaches to Renal Osteodystrophy miRNAseq analysis, Standard treatment for bone disorder - Renal Osteodystrophy, Chronic Kidney Diseases | Recruiting | Thomas Nickolas | 40 | 2022-12-21 | 2026-06-12 | |
| The Effects of 12-months of Denosumab on Bone Density in Prevalent Kidney Transplant Recipients Denosumab Inj 60 mg/ml, Placebo - Osteoporosis, Renal Osteodystrophy | Phase 2 | Terminated | Thomas Nickolas, MD MS | 8 | 2020-01-16 | 2024-07-25 |
| Diagnosis of Renal Osteodystrophy in Patients With Reduced Renal Function 18F-PET - Renal Osteodystrophy | Recruiting | Ditte Hansen | 40 | 2018-09-26 | 2025-03-18 | |
| The Effect of Etelcalcetide on CKD-MBD Etelcalcetide - Chronic Kidney Disease Mineral and Bone Disorder, Renal Osteodystrophy | Phase 2 | Completed | Thomas Nickolas, MD MS | 22 | 2018-09-06 | 2023-09-21 |
| Pathogenesis of Compromised Bone Quality and Mechanics in Chronic Kidney Disease Kidney disease - Chronic Kidney Disease, End Stage Kidney Disease | Completed | Columbia University | 50 | 2016-07-01 | 2021-07-13 | |
| Systematic Study of Parameters of Chronic Kidney Disease Mineral and Bone Disorder (CKD-MBD) Renal Osteodystrophy | Unknown | Hannover Medical School | 100 | 2015-02-01 | 2018-02-27 | |
| Clinical Observation on Bone Metabolism Induced by Chronic Renal Insufficiency Chronic Renal Insufficiency, Renal Osteodystrophy | Unknown | Shanghai University of Traditional Chinese Medicine | 300 | 2012-10-01 | 2021-09-23 | |
| Kidney Yin/Yang Replenishment on Patients With Renal Osteodystrophy Yougui granules, Zuogui granules, Yougui granules placebo - Renal Insufficiency, Chronic, Renal Osteodystrophy | Phase 2 | Withdrawn | Bing Shu | 2012-08-01 | 2017-05-08 | |
| Zoledronic Acid to Prevent Bone Loss After Kidney Transplantation Zoledronic acid - Renal Osteodystrophy | Phase 4 | Completed | University of Sao Paulo General Hospital | 34 | 2012-07-01 | 2014-05-19 |
| Serum Sclerostin Levels, Cardiovascular Parameters and Carpal Tunnel Syndrome in Maintenance Hemodialysis Patients Chronic Kidney Disease, Renal Osteodystrophy | Unknown | RFM Renal Treatment Services | 400 | 2011-07-01 | 2011-06-28 | |
| Vitamin D3 Substitution in Vitamin D Deficient Kidney Transplant Recipients Cholecalciferol, Placebo - Kidney Transplantation, Vitamin D Deficiency | Phase 3 | Unknown | Medical University of Vienna | 200 | 2009-05-01 | 2014-01-22 |
| Renal Osteodystrophy: A Fresh Approach Renal Osteodystrophy | Completed | Hartmut Malluche, MD | 464 | 2009-03-01 | 2017-05-05 | |
| Low Magnitude Mechanical Stimuli Effects on Bone Structure in ESRD Low magnitude mechanical stimuli - Renal Osteodystrophy | Not applicable | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 30 | 2006-05-01 | 2015-04-14 |
| Cholecalciferol Versus Doxercalciferol in the Treatment of Secondary Hyperparathyroidism in Chronic Kidney Disease doxercalciferol, Cholecalciferol - Renal Osteodystrophy | Not applicable | Completed | Indiana University | 55 | 2006-01-01 | 2016-05-02 |
| Klotho Gene Polymorphism in Dialyzed Patients With Hyperphosphatemia Chronic Kidney Disease, End Stage Renal Disease | Terminated | Assistance Publique - Hôpitaux de Paris | 40 | 2005-01-01 | 2007-11-08 | |
| Osteopenia and Renal Osteodystrophy: Evaluation and Management pamidronate - Osteopenia, Renal Osteodystrophy | Phase 4 | Completed | US Department of Veterans Affairs | 2002-10-01 | 2009-01-21 | |
| 12-month Study of AMG 073 in Renal Osteodystrophy AMG 073, Placebo - Renal Osteodystrophy | Phase 2 | Completed | Amgen | 45 | 2001-10-01 | 2013-05-08 |
| Regulation of Bone Formation in Renal Osteodystrophy 1 alpha D2, 1,25 dihydroxy vitamin D3, Sevelamer HCl - Secondary Hyperparathyroidism, Renal Osteodystrophy | Phase 2 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 61 | 2000-11-01 | 2010-01-14 |
| Phase II Randomized Study of the Effects of Growth Hormone on Children and Adolescents on Maintenance Dialysis calcitriol, growth hormone - Renal Osteodystrophy, End Stage Renal Disease | Phase 2 | Completed | National Center for Research Resources (NCRR) | 109 | 1995-06-01 | 2005-06-24 |
Chronic Kidney Disease-Mineral and Bone Disorder (19) · Renal Insufficiency, Chronic (6) · Hyperparathyroidism, Secondary (3) · Kidney Failure, Chronic (3) · Bone Diseases (2) · Bone Diseases, Metabolic (2) · Carpal Tunnel Syndrome (1) · Fractures, Bone (1) · Hyperparathyroidism (1) · Hyperphosphatemia (1) · Hypertrophy, Left Ventricular (1) · Kidney Diseases (1) · Neoplasm Metastasis (1) · Osteoporosis (1) · Rare Diseases (1)
Avitaminosis (19) · Calcium Metabolism Disorders (19) · Chronic Disease (19) · Deficiency Diseases (19) · Disease Attributes (19) · Endocrine System Diseases (19) · Female Urogenital Diseases (19) · Female Urogenital Diseases and Pregnancy Complications (19) · Male Urogenital Diseases (19) · Malnutrition (19) · Metabolic Diseases (19) · Musculoskeletal Diseases (19) · Nutrition Disorders (19) · Nutritional and Metabolic Diseases (19) · Parathyroid Diseases (19)
1 alpha-hydroxyergocalciferol (2) · Calcitriol (2) · Cholecalciferol (2) · Calcium Carbonate (1) · Cinacalcet (1) · Denosumab (1) · Growth Hormone (1) · Pamidronate (1) · Sevelamer (1) · Zoledronic Acid (1) · etelcalcetide hydrochloride (1)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2) · Thomas Nickolas, MD MS (2) · Amgen (1) · Assistance Publique - Hôpitaux de Paris (1) · Bing Shu (1) · Columbia University (1) · Ditte Hansen (1) · Hannover Medical School (1) · Hartmut Malluche, MD (1) · Indiana University (1) · Medical University of Vienna (1) · National Center for Research Resources (NCRR) (1) · RFM Renal Treatment Services (1) · Shanghai University of Traditional Chinese Medicine (1) · Thomas Nickolas (1)
United States (9) · China (2) · Austria (1) · Brazil (1) · Denmark (1) · France (1) · Germany (1) · Turkey (Türkiye) (1)
Thomas Nickolas, MD, MS (2) · Yongjun Wang, Doctor (2) · Elias David-Neto, MD (1) · Hartmut H Malluche, MD (1) · Isidro B Salusky, MD (1) · Isidro B. Salusky (1) · Kyra Borchhardt, MD (1) · Margret Patecki, MD (1) · Mary B Leonard, MD, MSCE (1) · Sharon Moe, MD (1) · Thomas Nickolas, MD,MS (1)
PMID 15930998, PMID 18397701, PMID 19480654, PMID 20056760, PMID 26546060, PMID 37574661, PMID 40576086
R01DK080770 (1), R01DK110871 (1), R01DK134101 (1), R21DK074105 (1)