5 completed, 3 recruiting, 2 terminated, 2 unknown. 13 Phase 2, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Completed 5, Recruiting 3, Terminated 2, Unknown 2, Active not recruiting 1 |
| Phase 1 | 2 | Terminated 1, Unknown 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Rectal Carcinoma: new trials by email Literature Review of Rectal Carcinoma trials Research Report on Rectal Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative Intent Treatment Zanidatamab, Resection, Patient Observation - Colon Carcinoma, Colorectal Carcinoma | Phase 2 | Recruiting | Emory University | 38 | 2026-04-07 | 2026-04-17 |
| Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer Biospecimen Collection, Prasterone, Survey Administration - Anal Carcinoma, Cervical Carcinoma | Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 25 | 2026-03-12 | 2026-04-21 |
| Study Evaluating the Tailored Management of Locally-advanced Rectal Carcinoma Induction chemotherapy - modified FOLFIRINOX regimen, Early tumor response evaluation by MRI volumetry, Radiochemotherapy Cap 50 - Locally Advanced Malignant Neoplasm, Rectal Carcinoma | Phase 2 / Phase 3 | Recruiting | Institut du Cancer de Montpellier - Val d'Aurelle | 1075 | 2021-11-26 | 2026-09-02 |
| Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients With Gastrointestinal Cancer Acupuncture Therapy, Acupressure Therapy, Oral Cryotherapy - Appendix Carcinoma, Colon Carcinoma | Phase 2 | Completed | University of Washington | 78 | 2021-06-01 | 2026-01-21 |
| Testing Diet Intervention Versus Non-Diet Intervention for Management of Bowel Symptoms in Rectal Cancer Survivors Best Practice, Dietary Intervention, Message - Rectal Carcinoma, Rectosigmoid Carcinoma | Phase 2 | Completed | SWOG Cancer Research Network | 95 | 2020-02-10 | 2024-05-01 |
| Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer, the RESTORE Study Explantation, Quality-of-Life Assessment, Questionnaire Administration - Low Anterior Resection Syndrome, Malignant Anal Neoplasm | Phase 2 | Terminated | M.D. Anderson Cancer Center | 3 | 2019-04-12 | 2023-08-14 |
| Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial) Adavosertib, Afatinib, Afatinib Dimaleate - Advanced Lymphoma, Advanced Malignant Solid Neoplasm | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 6452 | 2015-08-17 | 2026-10-26 |
| IMRT-SIB and Capecitabine in Preoperative Rectal Cancer Treatment IMRT-SIB, Capecitabine, Surgery - Rectal Carcinoma | Phase 2 | Unknown | Institute of Oncology Ljubljana | 50 | 2014-01-01 | 2014-10-20 |
| Phase II Study of Up-front Chemotherapy and Neo-adjuvant Short-course Radiotherapy for Resectable Rectal Carcinoma (COLORE) FOLFOX4, Tomotherapy, TME (Total Mesorectal Excision) - Rectal Carcinoma | Phase 2 | Completed | Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS | 52 | 2013-10-11 | 2025-01-30 |
| Multicenter Phase 2 Trial: a Tailored Strategy for Locally Advanced Rectal Carcinoma Induction trichemotherapy - FOLFIRINOX regimen, Early tumor response evaluation by MRI volumetry, Radiochemotherapy Cap 50 - Locally Advanced Malignant Neoplasm, Rectal Carcinoma | Phase 2 | Completed | Institut du Cancer de Montpellier - Val d'Aurelle | 150 | 2011-05-01 | 2017-08-21 |
| Inositol in Preventing Colorectal Cancer in Patients With Colitis-Associated Dysplasia Inositol, Placebo - Colon Carcinoma, Dysplasia in Crohn Disease | Phase 1 / Phase 2 | Terminated | National Cancer Institute (NCI) | 5 | 2010-10-01 | 2016-07-12 |
| Preoperative S-1/OHP With Radiation Therapy for Low-lying Rectal Carcinoma in Neo-adjuvant Setting S-1, Oxaliplatin, Radiation - Rectal Carcinoma | Phase 1 / Phase 2 | Unknown | Japan Clinical Cancer Research Organization | 45 | 2010-09-01 | 2012-11-27 |
| Genotype-directed Neoadjuvant Chemoradiation for Rectal Carcinoma 5FU, Radiation, Surgery of resectable lesions - Rectal Carcinoma | Phase 2 | Completed | Washington University School of Medicine | 135 | 2002-10-01 | 2017-10-06 |
Rectal Neoplasms (13) · Colonic Neoplasms (4) · Anus Neoplasms (3) · Uterine Cervical Neoplasms (3) · Carcinoma, Hepatocellular (2) · Colorectal Neoplasms (2) · Esophageal Neoplasms (2) · Ovarian Neoplasms (2) · Pancreatic Neoplasms (2) · Prostatic Neoplasms (2) · Stomach Neoplasms (2) · Urinary Bladder Neoplasms (2) · Uterine Neoplasms (2) · Vaginal Neoplasms (2) · Vulvar Neoplasms (2)
Digestive System Diseases (13) · Digestive System Neoplasms (13) · Gastrointestinal Diseases (13) · Intestinal Diseases (13) · Intestinal Neoplasms (13) · Neoplasms by Site (13) · Rectal Diseases (13) · Gastrointestinal Neoplasms (12) · Neoplasms (12) · Colorectal Neoplasms (11) · Colonic Diseases (5) · Anus Diseases (3) · Endocrine Gland Neoplasms (3) · Endocrine System Diseases (3) · Female Urogenital Diseases (3)
Specimen Handling (3) · Biopsy (2) · Magnetic Resonance Spectroscopy (2) · Radiation (2) · Surgical Procedures, Operative (2) · X-Rays (2) · 2-(3-(2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo(f)imidazo(1,2-d)(1,4)oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide (1) · 2C4 antibody (1) · AZD4547 (1) · Acupressure (1) · Acupuncture Therapy (1) · Ado-Trastuzumab Emtansine (1) · Afatinib (1) · CT-P6 (1) · Capecitabine (1)
Institut du Cancer de Montpellier - Val d'Aurelle (2) · National Cancer Institute (NCI) (2) · Emory University (1) · Institute of Oncology Ljubljana (1) · Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS (1) · Japan Clinical Cancer Research Organization (1) · M.D. Anderson Cancer Center (1) · Ohio State University Comprehensive Cancer Center (1) · SWOG Cancer Research Network (1) · University of Washington (1) · Washington University School of Medicine (1)
United States (8) · France (2) · Guam (2) · Italy (1) · Japan (1) · Puerto Rico (1) · Slovenia (1)
Alessandro Passardi, MD (1) · Allison M Quick, MD (1) · Benjamin Tan, M.D. (1) · Craig A Messick, MD (1) · Keith T Flaherty (1) · Olumide B. Gbolahan, MBBS, MSc (1) · Philippe Rouanet, MD (1) · Seema Khan (1) · Stacey Cohen (1) · Toshiaki Watanabe, M.D. (1) · Virginia Sun (1)
PMID 17042060, PMID 20920276, PMID 25612635, PMID 26586415, PMID 28594714, PMID 32463741, PMID 33048619, PMID 33343722, PMID 34759247, PMID 35133871, PMID 35138919, PMID 36351402, PMID 37053535, PMID 37322121, PMID 37934000, PMID 38591867, PMID 39666929, PMID 39693587, PMID 39913886, PMID 40865033, PMID 41066729
N01CN35157 (1), P30CA015704 (1), P30CA060553 (1), P30CA138292 (1), R21CA236057 (1), U10CA180820 (1), U24CA196172 (1), UG1CA189974 (1)