10 unknown, 8 completed, 7 recruiting, 5 active not recruiting. 13 Phase 2, 10 Not applicable, 6 Phase 3, 3 Phase 1, 1 Early Phase 1.
Follow Rectal Carcinoma: new trials by email Literature Review of Rectal Carcinoma trials Research Report on Rectal Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer Patients Dietary Fiber, Enema Administration, Loperamide Hydrochloride - Low Anterior Resection Syndrome, Rectal Carcinoma | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 80 | 2027-02-15 | 2026-10-06 |
| Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative Intent Treatment Zanidatamab, Resection, Patient Observation - Colon Carcinoma, Colorectal Carcinoma | Phase 2 | Recruiting | Emory University | 38 | 2026-04-07 | 2026-04-17 |
| Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer Biospecimen Collection, Prasterone, Survey Administration - Anal Carcinoma, Cervical Carcinoma | Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 25 | 2026-03-12 | 2026-04-21 |
| Pattern of Treatment and Outcomes of Locally Advanced Rectal Carcinoma No Intervention (subjects were previously treated with Onglyza®) - Rectal Carcinoma | Not yet recruiting | Sohag University | 100 | 2026-03-01 | 2026-01-23 | |
| Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays PAGODA algorithm, Oxaliplatin, Folinic Acid - Ampulla of Vater Carcinoma, Appendix Carcinoma | Not applicable | Recruiting | Alliance for Clinical Trials in Oncology | 420 | 2026-02-13 | 2026-10-28 |
| PET-imaging of Two Vartumabs in Patients With Solid Tumors 89Zr-DFO-N-Suc-F8scFv, 89Zr-DFO-N-Suc-C9scFv, PET/CT scan - Solid Tumor, Colon Carcinoma | Early Phase 1 | Recruiting | Var2 Pharmaceuticals | 32 | 2024-12-10 | 2025-12-29 |
| Contrast-Enhanced Photon-Counting Detector CT (PCD-CT) for the Local Staging of Rectal Cancer PCD-CT - Rectal Carcinoma | Recruiting | Mayo Clinic | 200 | 2024-10-07 | 2026-04-22 | |
| A Clinical Trial Comparing Staged Turnbull-Cutait Pull-through Anastomosis With Direct Anastomosis Plus Prophylactic Ileostomy in the Treatment of Low Rectal Cancer After Internal Sphincter Resection Delayed transanal pull-through anastomosis, Direct Anastomosis Plus Prophylactic Ileostomy - Rectal Cancer, Rectal Carcinoma | Not applicable | Active not recruiting | Zhongnan Hospital | 110 | 2024-05-08 | 2024-10-29 |
| Outcome of Laparoscopic Total Mesorectal Excision Versus Open Technique in Management of Rectal Carcimoma total mesorectal excision in rectal carcinoma - Rectal Carcinoma | Not applicable | Unknown | Sohag University | 50 | 2022-12-20 | 2023-01-17 |
| Study Evaluating the Tailored Management of Locally-advanced Rectal Carcinoma Induction chemotherapy - modified FOLFIRINOX regimen, Early tumor response evaluation by MRI volumetry, Radiochemotherapy Cap 50 - Locally Advanced Malignant Neoplasm, Rectal Carcinoma | Phase 2 / Phase 3 | Recruiting | Institut du Cancer de Montpellier - Val d'Aurelle | 1075 | 2021-11-26 | 2026-09-02 |
| Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients With Gastrointestinal Cancer Acupuncture Therapy, Acupressure Therapy, Oral Cryotherapy - Appendix Carcinoma, Colon Carcinoma | Phase 2 | Completed | University of Washington | 78 | 2021-06-01 | 2026-01-21 |
| Indocanine Green as Tracer for Lymph Nodes Dissection in Station 253 lymph nodes dissection at 253 station assisted by ICG - Rectal Carcinoma, Sigmoid Colon Carcinoma | Not applicable | Unknown | Nanfang Hospital, Southern Medical University | 66 | 2021-05-01 | 2021-04-19 |
| Changes in Pelvic Health, Sexual Function, and Quality of Life in Women With Pelvic Cancer Undergoing Radiation Therapy Pelvic Examination, Survey - Anal Carcinoma, Cervical Carcinoma | Active not recruiting | Ohio State University Comprehensive Cancer Center | 72 | 2021-01-30 | 2026-05-07 | |
| Testing Diet Intervention Versus Non-Diet Intervention for Management of Bowel Symptoms in Rectal Cancer Survivors Best Practice, Dietary Intervention, Message - Rectal Carcinoma, Rectosigmoid Carcinoma | Phase 2 | Completed | SWOG Cancer Research Network | 95 | 2020-02-10 | 2024-05-01 |
| PR in Endoscopic LAR for Rectal Cancer Pelvic floor Reconstruction - Rectal Carcinoma | Not applicable | Unknown | Southwest Hospital, China | 10 | 2019-09-01 | 2021-11-30 |
| Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer, the RESTORE Study Explantation, Quality-of-Life Assessment, Questionnaire Administration - Low Anterior Resection Syndrome, Malignant Anal Neoplasm | Phase 2 | Terminated | M.D. Anderson Cancer Center | 3 | 2019-04-12 | 2023-08-14 |
| COLOR III Trial: Transanal vs Laparoscopic TME Laparoscopic TME, TaTME - Rectal Carcinoma, Surgery | Phase 3 | Unknown | Amsterdam UMC, location VUmc | 1104 | 2016-12-02 | 2019-06-06 |
| Tumour and HEalthy Tissues DOse-response and Radiosensitivity Assay Standard treatment - Sarcoma, Rectal Carcinoma | Not applicable | Terminated | Centre Leon Berard | 97 | 2016-10-01 | 2020-03-25 |
| Robot-assisted Versus Laparoscopic Surgery for Mid/Low Rectal Cancer Robot-assisted resection, Laparoscopic resection - Rectal Carcinoma | Not applicable | Unknown | Fudan University | 1240 | 2016-07-10 | 2022-03-22 |
| Laparoscopic Anterior Resection With or Without "Dog Ear" Double-stapled Anastomosis for Rectal Cancer without "Dog Ear" group, with "Dog Ear" group - Rectal Carcinoma, Laparoscopy | Phase 3 | Unknown | Fujian Medical University | 250 | 2016-06-01 | 2016-05-12 |
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Rectal Neoplasms (34) · Colonic Neoplasms (8) · Esophageal Neoplasms (5) · Anus Neoplasms (4) · Pancreatic Neoplasms (4) · Stomach Neoplasms (4) · Urinary Bladder Neoplasms (4) · Uterine Cervical Neoplasms (4) · Carcinoma, Hepatocellular (3) · Sarcoma (3) · Vaginal Neoplasms (3) · Vulvar Neoplasms (3) · Appendiceal Neoplasms (2) · Breast Neoplasms (2) · Carcinoma, Renal Cell (2)
Digestive System Diseases (34) · Digestive System Neoplasms (34) · Gastrointestinal Diseases (34) · Intestinal Diseases (34) · Intestinal Neoplasms (34) · Neoplasms by Site (34) · Rectal Diseases (34) · Colorectal Neoplasms (32) · Gastrointestinal Neoplasms (32) · Neoplasms (32) · Colonic Diseases (10) · Female Urogenital Diseases (6) · Female Urogenital Diseases and Pregnancy Complications (6) · Head and Neck Neoplasms (6) · Neoplasms by Histologic Type (6)
Specimen Handling (3) · X-Rays (3) · Biopsy (2) · Capecitabine (2) · Fluorouracil (2) · Magnetic Resonance Spectroscopy (2) · Oxaliplatin (2) · Radiation (2) · Surgical Procedures, Operative (2) · 2-(3-(2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo(f)imidazo(1,2-d)(1,4)oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide (1) · 2C4 antibody (1) · AZD4547 (1) · Acupressure (1) · Acupuncture Therapy (1) · Ado-Trastuzumab Emtansine (1)
National Cancer Institute (NCI) (3) · Ohio State University Comprehensive Cancer Center (3) · Fujian Medical University (2) · Institut du Cancer de Montpellier - Val d'Aurelle (2) · Sohag University (2) · Alliance for Clinical Trials in Oncology (1) · Amsterdam UMC, location VUmc (1) · Centre Leon Berard (1) · City of Hope Medical Center (1) · Emory University (1) · Fudan University (1) · Institute of Oncology Ljubljana (1) · International Atomic Energy Agency (1) · Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS (1) · Japan Clinical Cancer Research Organization (1)
United States (15) · China (5) · France (4) · Guam (3) · Italy (2) · Netherlands (2) · Puerto Rico (2) · Algeria (1) · Belgium (1) · Brazil (1) · Canada (1) · Colombia (1) · Croatia (1) · Cuba (1) · Egypt (1)
Alessandra C Gasior, DO (1) · Alessandro Passardi, MD (1) · Allison M Quick, MD (1) · Antonio M. Lacy, MD, PhD (1) · Benjamin Tan, M.D. (1) · Christine D Berg (1) · Colin Sietses, MD, PhD (1) · Congqing Jiang, MD, PhD (1) · Craig A Messick, MD (1) · Eduardo Rosenblatt (1) · Elizabeth K Arthur, PhD (1) · Eric Francois (1) · Gabriel A. Brooks, MD, MPH (1) · George B. Hanna, MD, PhD (1) · Gooitzen van Dam, MD, PhD (1)
PMID 10789750, PMID 17042060, PMID 20004450, PMID 20920276, PMID 23014975, PMID 23288715, PMID 25612635, PMID 26269366, PMID 26559156, PMID 26586415, PMID 26902367, PMID 27781241, PMID 28594714, PMID 32463741, PMID 33048619, PMID 33277073, PMID 33343722, PMID 34548240, PMID 34759247, PMID 35133871, PMID 35138919, PMID 36087608, PMID 36107416, PMID 36351402, PMID 36515673, PMID 36535196, PMID 37053535, PMID 37322121, PMID 37934000, PMID 38591867, PMID 38741776, PMID 39527970, PMID 39666929, PMID 39693587, PMID 39913886, PMID 40405283, PMID 40455621, PMID 40804342, PMID 40865033, PMID 41066729, PMID 41261199, PMID 41887239, PMID 42114353
N01CN35157 (1), P30CA015704 (1), P30CA060553 (1), P30CA138292 (1), R21CA236057 (1), U10CA180820 (1), U24CA196172 (1), UG1CA189974 (1)