7 recruiting, 5 completed, 4 unknown, 2 withdrawn. 7 Not applicable, 4 Phase 4, 2 Phase 2, 1 Phase 1, 1 Phase 3.
Follow Prosthetic-joint Infection: new trials by email Literature Review of Prosthetic-joint Infection trials Research Report on Prosthetic-joint Infection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Methylene Blue in Total Knee Arthroplasty (TKA) Methylene Blue 10 MG/ML (intra-articular application), Revision Arthroplasty for PJI (DAIR), Primary Total Knee Arthroplasty - Total Knee Arthroplasty, Prosthetic-joint Infection | Phase 1 | Recruiting | University of Miami | 20 | 2026-02-04 | 2026-04-14 |
| Evaluation of PLG0206 in Prevention of Recurrent Infection in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Following Knee Arthroplasty PLG0206, Placebo - Prosthetic-joint Infection | Phase 2 / Phase 3 | Recruiting | Peptilogics | 240 | 2026-02-03 | 2026-10-26 |
| Knee Prosthetic Joint Infection Antibiotic Elution Treatment of Chronic TKA PJI - Prosthetic-joint Infection, Arthroplasty Complications | Withdrawn | University of Pittsburgh | 2026-01-05 | 2026-02-05 | ||
| Probiotics in the Prevention of Recurrent Prosthetic Joint Infection of the Hip and Knee Probiotic, Standard of care - Prosthetic-joint Infection, Dysbiosis | Phase 4 | Enrolling by invitation | Boston Medical Center | 152 | 2025-08-15 | 2026-08-26 |
| The Effect of Peri-Operative Adjunctive Probiotics on Immunological Markers in Cases of Prosthetic Joint Infection of the Hip and Knee Culturelle Digestive Daily Probiotic Capsule - Prosthetic-joint Infection | Not applicable | Recruiting | NYU Langone Health | 152 | 2025-07-12 | 2026-03-04 |
| Real-component vs All-cement Articulating Spacers for Periprosthetic Knee Infection All-cement articulating spacer, Durable, real-component articulating spacer, Rigid Spacer - Prosthetic-joint Infection, Knee Infection | Not applicable | Recruiting | Northwestern University | 153 | 2024-08-08 | 2026-08-24 |
| Evaluation of Arthroplasty Treatment Joint replacement - Surgery, Knee Arthropathy | Recruiting | University Hospital, Bonn | 300 | 2024-07-01 | 2026-09-02 | |
| Incidence of Early Infection After Bipolar Hemiarthroplasty and Its Associated Factors in Fracture Neck of Femur bipolar hemiarthroplasty - Prosthetic-joint Infection | Unknown | Assiut University | 74 | 2024-06-01 | 2024-05-24 | |
| Benzoyl Peroxide and Electrocautery Skin Incision to Eradicate Cutibacterium Acnes Benzoyl Peroxide Topical, Electrocautery surgical skin incision - Prosthetic-joint Infection | Phase 4 | Withdrawn | University of Missouri-Columbia | 2024-06-01 | 2024-07-15 | |
| LE as a Marker for Periprosthetic Joint Infection Semi-quantitative electrochemical leukocyte esterse test strip, Roche Chemstrip - Prosthetic-joint Infection | Unknown | Center for Innovation and Research Organization | 160 | 2023-12-07 | 2024-01-30 | |
| SURGX Antimicrobial Gel Versus Povidone-iodine Skin Incision Prep in Total Shoulder Arthroplasty Povidone-Iodine, SURGX Wound Gel - Surgery, Surgical Site Infection | Phase 4 | Completed | St. Louis University | 60 | 2023-06-26 | 2024-12-10 |
| Rifampicin Combination Therapy Versus Monotherapy for Staphylococcal Prosthetic Joint Infection Clindamycin, Rifampicin and levofloxacin - Prosthetic-joint Infection, Infection Hip | Phase 4 | Recruiting | Leiden University Medical Center | 316 | 2023-04-01 | 2023-12-15 |
| A Second Trial of the Abbreviated Protocol Two-Stage Exchange VT-X7 Treatment System, Two-stage exchange arthroplasty, SOC Antibiotics - Prosthetic-joint Infection | Phase 2 | Completed | Osteal Therapeutics, Inc. | 76 | 2023-01-23 | 2025-01-07 |
| SHort Interval Full Two-stage Implant Exchange Early prosthesis reimplantation, Retrospective analysis of medical records - Prosthetic-joint Infection | Not applicable | Recruiting | University Hospital, Montpellier | 100 | 2023-01-23 | 2024-08-06 |
| Physiopathology of Prosthetic Joint Infections Prosthetic-joint Infection | Unknown | Assistance Publique - Hôpitaux de Paris | 20 | 2022-10-01 | 2022-09-22 | |
| Surgiphor vs Saline Joints Surgiphor Irrigation Solution, Sterile saline - Prosthetic-joint Infection | Not applicable | Unknown | Center for Innovation and Research Organization | 868 | 2022-09-19 | 2023-09-11 |
| Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With a Fracture Antibiotic dosage practice - Fracture of Hip, Total Hip Arthroplasty | Not applicable | Active not recruiting | Soren Overgaard | 2000 | 2022-09-01 | 2025-03-24 |
| Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With OA Antibiotic dosage practice - Osteoarthritis, Hip, Total Hip Arthroplasty | Not applicable | Completed | Soren Overgaard | 20000 | 2022-09-01 | 2026-07-08 |
| Is This PJI Really Acute: A Quantitative Sonication Fluid Analysis (Sonic) Prosthetic-joint Infection | Completed | University Hospital, Basel, Switzerland | 176 | 2021-06-30 | 2025-01-22 | |
| Arthroplasty and Modifiable Risk Factors Early preoperative assessment and optimization - Total Joint Arthroplasty, Risk Reduction | Not applicable | Completed | Landspitali University Hospital | 1484 | 2018-08-20 | 2023-10-04 |
Showing 20 of 21. Sign in to see all of them.
Surgical Wound Infection (3) · Dysbiosis (1) · Hip Fractures (1) · Infections (1) · Osteoarthritis (1) · Osteoarthritis, Hip (1) · Postoperative Complications (1) · Prosthesis Failure (1) · Reinfection (1) · Risk Reduction Behavior (1)
Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Infections (3) · Postoperative Complications (3) · Wound Infection (3) · Arthritis (1) · Behavior (1) · Disease Attributes (1) · Femoral Fractures (1) · Fractures, Bone (1) · Hip Injuries (1) · Joint Diseases (1) · Leg Injuries (1) · Musculoskeletal Diseases (1) · Recurrence (1)
Arthroplasty (1) · Arthroplasty, Replacement (1) · Benzoyl Peroxide (1) · Clindamycin (1) · Levofloxacin (1) · Methylene Blue (1) · Povidone-Iodine (1) · Probiotics (1) · Rifampin (1) · Sodium Chloride (1) · Standard of Care (1)
Center for Innovation and Research Organization (2) · Osteal Therapeutics, Inc. (2) · Soren Overgaard (2) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Boston Medical Center (1) · Landspitali University Hospital (1) · Leiden University Medical Center (1) · NYU Langone Health (1) · Northwestern University (1) · Peptilogics (1) · St. Louis University (1) · University Hospital, Basel, Switzerland (1) · University Hospital, Bonn (1) · University Hospital, Montpellier (1)
United States (12) · Denmark (2) · France (2) · Germany (1) · Iceland (1) · Netherlands (1) · Switzerland (1) · United Kingdom (1)
Armita A Abedi, MD (2) · Adam I Edelstein, MD (1) · Andreas C. Strauss, PD Dr. med. (1) · Ayesha Abdeen, MD (1) · Colin A McNamara, MD, MBA (1) · Henk Scheper, MD (1) · Hyunmin M Kim, MD (1) · Johannes F Plate, MD, PhD (1) · Martin Clauss, PD Dr. med. (1) · Nicolas Piuzzi, MD (1) · Ran Schwarzkopf, MD (1) · Randall Otto, MD (1) · Sigurbergur Karason, Professor (1)