5 recruiting, 4 completed, 2 unknown, 1 active not recruiting. 14 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 14 | Recruiting 5, Completed 4, Unknown 2, Active not recruiting 1, Terminated 1, Withdrawn 1 |
Follow Prodromal Symptoms: new trials by email Literature Review of Prodromal Symptoms trials Research Report on Prodromal Symptoms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Accelerated Neuromodulation Therapy and Neurocomputational Biomarkers in Individuals at Clinical High Risk for Psychosis Active Intermittent Theta Burst Stimulation (BEAM-F3 Targeting), Sham Comparator: Sham iTBS - Clinical High Risk for Psychosis (CHR), Psychotic Disorders | Not applicable | Recruiting | Douglas Mental Health University Institute | 40 | 2026-08-01 | 2026-08-28 |
| Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity Increase of physical activity volume and intensity with the use of a motivational smartphone application - Parkinson Disease, Prodromal Stage | Not applicable | Recruiting | University Hospital, Bonn | 130 | 2025-12-04 | 2026-01-16 |
| Slow-SPEED: Slowing Parkinson's Early Through Exercise Dosage Increase of physical activity volume and intensity with the use of a motivational smartphone application - Parkinson Disease, Prodromal Stage | Not applicable | Recruiting | Radboud University Medical Center | 600 | 2025-09-01 | 2026-10-15 |
| DMHI for At-Risk College Students SPARK Coping - Prodromal Symptoms, Psychosis | Not applicable | Completed | University of Washington | 50 | 2024-10-04 | 2025-12-17 |
| Seeing the Light: Early Intervention in People at Risk for Bipolar Disorder Bright light therapy + Psycho-education + Imagery focused Cognitive Therapy, Blue-light blocking glasses + Psycho-education + Imagery focused Cognitive Therapy, Psycho-education + Imagery focused Cognitive Therapy - Bipolar Disorder, Mood Swing | Not applicable | Unknown | Geestelijke Gezondheidszorg Eindhoven (GGzE) | 50 | 2024-05-01 | 2024-04-11 |
| Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-Netherlands Increase of physical activity volume and intensity with the use of a motivational smartphone application - Parkinson Disease, Prodromal Stage | Not applicable | Recruiting | Radboud University Medical Center | 110 | 2024-01-15 | 2026-08-27 |
| Self-Care for Dementia Caregivers Behavioral Self-Monitoring + Motivational Interviewing - Aging, Mental Disorder | Not applicable | Completed | University of Pittsburgh | 21 | 2023-03-07 | 2026-01-23 |
| REtinal and VIsual Cortical Response in Early PSYchosis Retinaute (BioSerenity), EEG Headset 64 electrodes (BioSemi), MonPackOne (Metrovision) - Prodromal Schizophrenia, Psychotic Episode | Not applicable | Terminated | Centre Psychothérapique de Nancy | 34 | 2022-01-26 | 2024-08-22 |
| Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk SCORES (Specific COgnitive Remediation with Support) - Psychosis, Prodromal Schizophrenia | Not applicable | Recruiting | Northwell Health | 54 | 2021-10-28 | 2025-11-24 |
| Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy Trial Family Focused Therapy for Clinical High Risk Youth (FFT-CHR), Enhanced Care (EC) - Psychotic Disorders, Prodromal Symptoms | Not applicable | Active not recruiting | University of California, Los Angeles | 220 | 2021-01-15 | 2026-01-26 |
| MBCT and CBT for Youth at High Risk for Mood and Psychotic Disorders: a Randomized Controlled Trial cognitive behavioral therapy, mindfulness-based cognitive therapy - Mood Disorders, Prodromal Symptoms | Not applicable | Completed | University of California, Los Angeles | 66 | 2020-01-14 | 2022-10-12 |
| HOPE TEAM - Clinical High Risk Group CBSST Cognitive Behavioral Therapy - Prodromal Symptoms, Prodromal Stage | Not applicable | Withdrawn | University of Pittsburgh | 2019-09-01 | 2020-02-07 | |
| Recognition and Early Intervention on Prodrome in Bipolar Disorders aerobic exercise, psychoeducation - Bipolar Disorder | Not applicable | Unknown | Guangzhou Psychiatric Hospital | 120 | 2013-03-01 | 2015-03-17 |
| Cognitive Behavioral Therapy for the Prevention of Paranoia in Adolescents at High Risk Cognitive Behavioral Therapy - ARMS, APS | Not applicable | Completed | Weill Medical College of Cornell University | 13 | 2012-10-01 | 2018-12-04 |
Psychotic Disorders (7) · Basal Ganglia Diseases (3) · Bipolar Disorder (3) · Brain Diseases (3) · Central Nervous System Diseases (3) · Nervous System Diseases (3) · Neurodegenerative Diseases (3) · Parkinson Disease (3) · Parkinsonian Disorders (3) · Schizotypal Personality Disorder (3) · Synucleinopathies (3) · Dementia (2) · Motor Activity (2) · Alzheimer Disease (1)
Pathological Conditions, Signs and Symptoms (14) · Signs and Symptoms (14) · Mental Disorders (12) · Schizophrenia Spectrum and Other Psychotic Disorders (7) · Behavior (4) · Bipolar and Related Disorders (3) · Metabolic Diseases (3) · Movement Disorders (3) · Nutritional and Metabolic Diseases (3) · Personality Disorders (3) · Proteostasis Deficiencies (3) · Mood Disorders (2) · Neurocognitive Disorders (2) · Autonomic Nervous System Diseases (1) · Brain Diseases (1)
Cognitive Behavioral Therapy (3) · Exercise (1) · Mindfulness-Based Cognitive Therapy (1) · Motivational Interviewing (1) · Palliative Care (1) · Population Groups (1) · Ultraviolet Therapy (1)
Radboud University Medical Center (2) · University of California, Los Angeles (2) · University of Pittsburgh (2) · Centre Psychothérapique de Nancy (1) · Douglas Mental Health University Institute (1) · Geestelijke Gezondheidszorg Eindhoven (GGzE) (1) · Guangzhou Psychiatric Hospital (1) · Northwell Health (1) · University Hospital, Bonn (1) · University of Washington (1) · Weill Medical College of Cornell University (1)
United States (8) · Netherlands (3) · Canada (2) · China (1) · France (1) · Germany (1)
Sirwan KL Darweesh, PhD (2) · Andrea M. Auther, Ph.D. (1) · Barbara A. Cornblatt, Ph.D., M.B.A. (1) · Ben Buck, PhD (1) · Carrie E. Bearden, Ph.D. (1) · Daniel H. Mathalon, Ph.D., M.D. (1) · Danielle M. Denenny, PhD (1) · David Benrimoh (1) · David J. Miklowitz, Ph.D. (1) · David Miklowitz, PhD (1) · Guiyun Xu, M.D (1) · Holly K. Hamilton, Ph.D. (1) · Inge Bongers, Prof. Dr. (1) · Jean M. Addington, Ph.D. (1) · Kangguang Lin, M.D (1)
PMID 42448717, PMID 36649157, PMID 41572055, PMID 41688680, PMID 42815039
P30AG024978 (1), P50MH115837 (1), R01MH123575 (1), R33MH123574 (1), R41AG069596 (1), R61MH123574 (1)