6 completed, 6 recruiting, 4 unknown, 1 active not recruiting. 14 Not applicable, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 14 | Recruiting 5, Completed 4, Unknown 2, Active not recruiting 1, Terminated 1, Withdrawn 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Prodromal Symptoms: new trials by email Literature Review of Prodromal Symptoms trials Research Report on Prodromal Symptoms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Accelerated Neuromodulation Therapy and Neurocomputational Biomarkers in Individuals at Clinical High Risk for Psychosis Active Intermittent Theta Burst Stimulation (BEAM-F3 Targeting), Sham Comparator: Sham iTBS - Clinical High Risk for Psychosis (CHR), Psychotic Disorders | Not applicable | Recruiting | Douglas Mental Health University Institute | 40 | 2026-08-01 | 2026-08-28 |
| Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity Increase of physical activity volume and intensity with the use of a motivational smartphone application - Parkinson Disease, Prodromal Stage | Not applicable | Recruiting | University Hospital, Bonn | 130 | 2025-12-04 | 2026-01-16 |
| Slow-SPEED: Slowing Parkinson's Early Through Exercise Dosage Increase of physical activity volume and intensity with the use of a motivational smartphone application - Parkinson Disease, Prodromal Stage | Not applicable | Recruiting | Radboud University Medical Center | 600 | 2025-09-01 | 2026-10-15 |
| DMHI for At-Risk College Students SPARK Coping - Prodromal Symptoms, Psychosis | Not applicable | Completed | University of Washington | 50 | 2024-10-04 | 2025-12-17 |
| Seeing the Light: Early Intervention in People at Risk for Bipolar Disorder Bright light therapy + Psycho-education + Imagery focused Cognitive Therapy, Blue-light blocking glasses + Psycho-education + Imagery focused Cognitive Therapy, Psycho-education + Imagery focused Cognitive Therapy - Bipolar Disorder, Mood Swing | Not applicable | Unknown | Geestelijke Gezondheidszorg Eindhoven (GGzE) | 50 | 2024-05-01 | 2024-04-11 |
| Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-Netherlands Increase of physical activity volume and intensity with the use of a motivational smartphone application - Parkinson Disease, Prodromal Stage | Not applicable | Recruiting | Radboud University Medical Center | 110 | 2024-01-15 | 2026-08-27 |
| Self-Care for Dementia Caregivers Behavioral Self-Monitoring + Motivational Interviewing - Aging, Mental Disorder | Not applicable | Completed | University of Pittsburgh | 21 | 2023-03-07 | 2026-01-23 |
| REtinal and VIsual Cortical Response in Early PSYchosis Retinaute (BioSerenity), EEG Headset 64 electrodes (BioSemi), MonPackOne (Metrovision) - Prodromal Schizophrenia, Psychotic Episode | Not applicable | Terminated | Centre Psychothérapique de Nancy | 34 | 2022-01-26 | 2024-08-22 |
| Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk SCORES (Specific COgnitive Remediation with Support) - Psychosis, Prodromal Schizophrenia | Not applicable | Recruiting | Northwell Health | 54 | 2021-10-28 | 2025-11-24 |
| Prodromal and Overt Parkinson's Disease Epidemiological Study in Brazil Parkinson Disease, Parkinsonism | Unknown | Hospital de Clinicas de Porto Alegre | 8000 | 2021-04-30 | 2023-03-02 | |
| Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy Trial Family Focused Therapy for Clinical High Risk Youth (FFT-CHR), Enhanced Care (EC) - Psychotic Disorders, Prodromal Symptoms | Not applicable | Active not recruiting | University of California, Los Angeles | 220 | 2021-01-15 | 2026-01-26 |
| MBCT and CBT for Youth at High Risk for Mood and Psychotic Disorders: a Randomized Controlled Trial cognitive behavioral therapy, mindfulness-based cognitive therapy - Mood Disorders, Prodromal Symptoms | Not applicable | Completed | University of California, Los Angeles | 66 | 2020-01-14 | 2022-10-12 |
| Youth Experiences and Health Study Psychiatric questionnaires, Semi-structured psychiatric interview - Psychotic Disorders, Psychiatric Hospitalization | Unknown | Finnish Institute for Health and Welfare | 1000 | 2019-12-01 | 2024-09-25 | |
| HOPE TEAM - Clinical High Risk Group CBSST Cognitive Behavioral Therapy - Prodromal Symptoms, Prodromal Stage | Not applicable | Withdrawn | University of Pittsburgh | 2019-09-01 | 2020-02-07 | |
| A Study in Subjects With Late Prodromal & Early Manifest HD to Assess the Safety, Tolerability, pk, and Efficacy of Pepi VX15/2503, Placebo - Huntington's Disease | Phase 2 | Completed | Vaccinex Inc. | 301 | 2015-07-01 | 2022-05-02 |
| The Early Warning System for the Diabetic Encephalopathy Diabetes Mellitus Type 2, Mild Cognitive Impairment | Recruiting | Tang-Du Hospital | 300 | 2015-04-01 | 2022-07-13 | |
| Recognition and Early Intervention on Prodrome in Bipolar Disorders aerobic exercise, psychoeducation - Bipolar Disorder | Not applicable | Unknown | Guangzhou Psychiatric Hospital | 120 | 2013-03-01 | 2015-03-17 |
| Cognitive Behavioral Therapy for the Prevention of Paranoia in Adolescents at High Risk Cognitive Behavioral Therapy - ARMS, APS | Not applicable | Completed | Weill Medical College of Cornell University | 13 | 2012-10-01 | 2018-12-04 |
| Early Pharmacological and Psychological Intervention for Late Prodromal States of Psychosis Supportive management, Amisulpride - Schizophrenia, Psychoses | Phase 4 | Completed | University of Cologne | 124 | 2001-01-01 | 2014-12-24 |
Psychotic Disorders (9) · Neurodegenerative Diseases (4) · Parkinson Disease (4) · Parkinsonian Disorders (4) · Basal Ganglia Diseases (3) · Bipolar Disorder (3) · Brain Diseases (3) · Central Nervous System Diseases (3) · Nervous System Diseases (3) · Schizotypal Personality Disorder (3) · Synucleinopathies (3) · Cognitive Dysfunction (2) · Dementia (2) · Motor Activity (2)
Pathological Conditions, Signs and Symptoms (19) · Signs and Symptoms (19) · Mental Disorders (17) · Schizophrenia Spectrum and Other Psychotic Disorders (9) · Movement Disorders (5) · Behavior (4) · Metabolic Diseases (4) · Neurocognitive Disorders (4) · Nutritional and Metabolic Diseases (4) · Bipolar and Related Disorders (3) · Brain Diseases (3) · Central Nervous System Diseases (3) · Cognition Disorders (3) · Nervous System Diseases (3) · Personality Disorders (3)
Cognitive Behavioral Therapy (3) · Amisulpride (1) · Exercise (1) · Mindfulness-Based Cognitive Therapy (1) · Motivational Interviewing (1) · Palliative Care (1) · Population Groups (1) · Ultraviolet Therapy (1) · pepinemab (1)
Radboud University Medical Center (2) · University of California, Los Angeles (2) · University of Pittsburgh (2) · Centre Psychothérapique de Nancy (1) · Douglas Mental Health University Institute (1) · Finnish Institute for Health and Welfare (1) · Geestelijke Gezondheidszorg Eindhoven (GGzE) (1) · Guangzhou Psychiatric Hospital (1) · Hospital de Clinicas de Porto Alegre (1) · Northwell Health (1) · Tang-Du Hospital (1) · University Hospital, Bonn (1) · University of Cologne (1) · University of Washington (1) · Vaccinex Inc. (1)
United States (9) · Canada (3) · Netherlands (3) · China (2) · Germany (2) · Brazil (1) · Finland (1) · France (1)
Sirwan KL Darweesh, PhD (2) · Andrea M. Auther, Ph.D. (1) · Andrew Feigin, MD (1) · Artur F Schuh-Schumacher, Dr. (1) · Barbara A. Cornblatt, Ph.D., M.B.A. (1) · Ben Buck, PhD (1) · Carrie E. Bearden, Ph.D. (1) · Daniel H. Mathalon, Ph.D., M.D. (1) · Danielle M. Denenny, PhD (1) · David Benrimoh (1) · David J. Miklowitz, Ph.D. (1) · David Miklowitz, PhD (1) · Guangbin Cui, professor (1) · Guiyun Xu, M.D (1) · Holly K. Hamilton, Ph.D. (1)
PMID 42448717, PMID 27552827, PMID 29615873, PMID 30103342, PMID 30991623, PMID 35941373, PMID 36463457, PMID 36649157, PMID 39893169, PMID 41572055, PMID 41688680, PMID 42815039
P30AG024978 (1), P50MH115837 (1), R01MH123575 (1), R33MH123574 (1), R41AG069596 (1), R61MH123574 (1)