68 completed, 15 unknown, 12 not yet recruiting, 12 recruiting. 93 Not applicable, 8 Phase 3, 7 Phase 4, 2 Phase 2, 1 Early Phase 1.
Follow Procedural Pain: new trials by email Literature Review of Procedural Pain trials Research Report on Procedural Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| VR-PAT and fNIRS to Identify CNS Biomarkers of Pain VR-PAT - Acute Pain, Pediatric ALL | Not applicable | Not yet recruiting | Nationwide Children's Hospital | 4 | 2027-07-01 | 2026-09-09 |
| E-MOHS Trial of TENS and Vibration During Local Anesthesia Active Vibration:TENS, Sham TENS - Pain, Procedural Pain | Not applicable | Not yet recruiting | University of Minnesota | 90 | 2027-01-01 | 2026-10-06 |
| Virtual Reality (VR) Audiovisual Distraction to Reduce Pain and Anxiety for Prone Pain Procedures Virtual Reality (VR) Audiovisual Distraction - Procedural Pain, Procedural Anxiety | Not applicable | Not yet recruiting | University of California, Davis | 230 | 2026-10-01 | 2026-08-21 |
| Crochet Octopus in Reducing Procedural Pain During Heel Lance in Preterm Neonates Crochet Octopus - Preterm Neonates, Heel Lance Procedures | Not applicable | Not yet recruiting | Mansoura University | 98 | 2026-10-01 | 2026-09-23 |
| Stress-Ball Distraction for Pain and Anxiety During Painful Procedures in Critically Ill Patients Stress-Ball Distraction, Standard care - Procedural Pain | Not applicable | Not yet recruiting | Alexandria University | 104 | 2026-09-30 | 2026-09-23 |
| Cold Spray and Helfer Skin Tap for Pain During Infant Vaccination Cold spray, Helfer Skin Tap Technique - Procedural Pain, Vaccination Pain | Not applicable | Not yet recruiting | Hitit University | 120 | 2026-09-15 | 2026-08-21 |
| The Effect of Using a Stress Ball on Pain, Anxiety, and Vital Signs During Breast Biopsy Using a Stress Ball - Breast Biopsy, Procedural Pain | Not applicable | Recruiting | TC Erciyes University | 53 | 2026-09-11 | 2026-09-28 |
| TEAS for Sedation During ERCP: A Multicenter Trial With Mechanistic Substudy TEAS + Conscious Sedation, Sham TEAS + Conscious Sedation - Endoscopic Retrograde Cholangiopancreatography, Conscious Sedation Adverse Event | Not applicable | Not yet recruiting | Beijing 302 Hospital | 130 | 2026-09-01 | 2026-06-16 |
| Effects of Robotic Pet and Video-Based Distraction on Pain, Fear, and Anxiety in Children During Venipuncture Robotic Pet-Based Distraction, Video-Based Distraction - Procedural Pain, Anxiety | Not applicable | Completed | Akdeniz University | 90 | 2026-07-13 | 2026-08-19 |
| THE EFFECT OF 'RHYTHMİC SKİN TAPPİNG' AND INTERNAL VİBRATİON APPLİED PROXİMAL TO THE PROCEDURE SİTE ON PAİN AND FEAR PERCEPTİON DURİNG PEDİATRİC PERİPHERAL VENİPUNCTURE Rhythmic Skin Tapping, Internal Vibration (Humming) - Procedural Pain, Acute Pain | Not applicable | Recruiting | Akdeniz University | 126 | 2026-07-01 | 2026-08-19 |
| Distraction Cards Versus Emotion-Regulation Toy Squeezing During Intramuscular Vaccination in Preschool Children Distraction-Card Group, Emotion-Regulation Toy-Squeezing Group - Procedural Pain, Pain-related Fear | Not applicable | Recruiting | Mersin University | 68 | 2026-06-27 | 2026-09-21 |
| Cartoon Watching Versus Ball Squeezing During Venous Blood Sampling in Children Cartoon-Watching Group, Ball-Squeezing Group - Procedural Pain, Pain-related Fear | Not applicable | Completed | Mersin University | 68 | 2026-06-21 | 2026-09-09 |
| The Effect of Kangaroo Care on Pain in Infants Receiving Phototherapy Kangaroo Care, Routine Care - Procedural Pain, Neonatal Hyperbilirubinemia | Not applicable | Recruiting | Marmara University | 45 | 2026-06-01 | 2026-08-12 |
| Effects of Binaural Beats on Pain and Anxiety During Flexible Cystoscopy Procedural Pain, Anxiety | Completed | Saglik Bilimleri Universitesi | 120 | 2026-06-01 | 2026-10-19 | |
| Stress Ball and Empathic Verbal-Tactile Interventions for Reducing Anxiety and Pain in Mammography and Breast Ultrasonography: A Randomized Trial Stress Ball, Empathic Verbal-Tactile Intervention - Procedural Anxiety, Procedural Pain | Not applicable | Not yet recruiting | Istanbul University | 122 | 2026-05-04 | 2026-05-01 |
| The Effect of Two Different Types of Hourglasses on Pain, Fear, and Anxiety Liquid Gel-Based Hourglass, Sand-Based Hourglass - Pain, Fear | Not applicable | Completed | Hakkari Universitesi | 120 | 2026-05-01 | 2026-09-15 |
| Comparison of Needle-Free Injection and Conventional Syringe for Tooth Extractions in Children Needle-Free Jet Injection System, Conventional Syringe Injection - Tooth Extraction, Dental Anxiety | Not applicable | Not yet recruiting | Ondokuz Mayıs University | 60 | 2026-04-15 | 2026-04-29 |
| Artificial Intelligence-Supported Visual Guide for Preschool Children Undergoing Medical Procedures AI-Supported Visual Guide - Procedural Anxiety, Procedural Pain | Not applicable | Completed | Istanbul Bilgi University | 110 | 2026-04-14 | 2026-07-15 |
| Topical Lidocaine for Digital Nerve Block Pain Topical Lidocaine Spray, Placebo Spray - Finger Injuries, Procedural Pain | Phase 4 | Completed | Ankara City Hospital Bilkent | 240 | 2026-04-01 | 2026-09-22 |
| Effect of Stress Ball Use on Pain, Anxiety, and Vital Signs During Ultrasound-Guided Tru-cut Biopsy Behavioral: Stress Ball Application - Procedural Pain, Anxiety | Not applicable | Completed | Istanbul University | 79 | 2026-03-15 | 2026-05-29 |
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Pain, Procedural (114) · Pain (30) · Anxiety Disorders (18) · Acute Pain (12) · Agnosia (11) · Neoplasms (5) · Burns (4) · Iatrophobia (2) · Patient Satisfaction (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2) · Angina, Stable (1) · Angina, Unstable (1) · Arterial Occlusive Diseases (1) · Arteriovenous Fistula (1) · Cancer Pain (1)
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Egidio Barbi, MD (2) · Henry Xiang, MD, MPH, PhD, MBA (2) · Zeynep Erkut, PhD (2) · Agostino Guarino, RN (1) · Anjanique Mariquit Lu, MD (1) · Aynur Aytekin Ozdemir, PhD (1) · Aysegul Simsek, PhD (1) · Bahar Aksoy, PhD (1) · Bei-yu Wu, doctor (1)
PMID 10915627, PMID 11994056, PMID 15278085, PMID 16330518, PMID 16428010, PMID 16580851, PMID 18245406, PMID 18299545, PMID 18385262, PMID 18387963, PMID 18450903, PMID 19482767, PMID 19505775, PMID 21806301, PMID 23057434, PMID 23957021, PMID 24108531, PMID 24696691, PMID 24918475, PMID 25551218, PMID 25555856, PMID 26164784, PMID 26755209, PMID 27112434, PMID 27409593, PMID 28779961, PMID 28890146, PMID 29290273, PMID 29559294, PMID 30555754, PMID 31000379, PMID 31477677, PMID 31628067, PMID 31889358, PMID 3195771, PMID 32540887, PMID 33087584, PMID 33296028, PMID 33434097, PMID 33485746, PMID 33593096, PMID 34014258, PMID 34969619, PMID 35982492, PMID 36525534, PMID 37163686, PMID 37407711, PMID 37773297, PMID 37863785, PMID 37923615
2016 (1), R44HD056647 (1)