29 completed, 16 recruiting, 12 unknown, 5 active not recruiting. 36 Not applicable, 6 Phase 4, 4 Phase 2, 2 Phase 3.
Follow Pregnancy, High Risk: new trials by email Literature Review of Pregnancy, High Risk trials Research Report on Pregnancy, High Risk
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| MOCHA: Embedded Inpatient Mental Health Care for High-Risk Perinatal Patients Collaborative Mental Health Care Program (CMHCP) - Anxiety Disorders, Stress Disorders, Post-Traumatic | Recruiting | Indiana University | 50 | 2026-07-15 | 2026-09-08 | |
| NOURISH - A Healthcare-community Partnership to Improve Nutrition for Optimal Glycemic Control and Pregnancy Outcomes With Pregestational Diabetes Mid-Ohio Food Farmacy (MOF+) produce delivery, Nutrition education with Dining with Diabetes (DWD), Health Impact Ohio Central Ohio Pathways Hub to address unmet social needs - Type 2 Diabetes, Type 1 Diabetes | Not applicable | Recruiting | Ohio State University | 174 | 2026-07-06 | 2026-08-14 |
| Permissive Versus Strict Intrapartum Glucose Management in Type 1 Diabetes (PRISM-T1D) Insulin, DEXCOM Continuous Glucose Monitor - Pregnancy, High Risk, Type 1 Diabetes | Phase 4 | Recruiting | Ohio State University | 44 | 2026-02-25 | 2026-04-29 |
| Relationship of DV Doppler Parameters to Perinatal Outcomes in IUGR vs Non-IUGR Fetal Growth Restriction, Perinatal Outcome | Not yet recruiting | Izmir City Hospital | 160 | 2025-10-01 | 2025-10-02 | |
| Continuous Glucose Monitoring (CGM) Substudy of the DECIDE RCT CGM device - Metformin group, CGM device - Insulin group - Gestational Diabetes Mellitus, Pregnancy, High Risk | Withdrawn | Ohio State University | 2025-09-01 | 2025-10-28 | ||
| Early Detection of Gestational Diabetes Mellitus in Pregnancy Enhanced First Trimester GDM Screening, Routine Gestational Diabetes Screening - Gestational Diabetes Mellitus in Pregnancy, Pregnancy, High Risk | Not applicable | Recruiting | University of Massachusetts, Worcester | 80 | 2025-07-01 | 2026-04-06 |
| MYFEMBREE®: A Retrospective Cohort Study Using an Administrative Healthcare Database to Assess Pregnancy Outcomes in Women Treated With Relugolix Combination Therapy Relugolix + Estradiol + Norethindrone Acetate - Pregnancy Related, Pregnancy Complications | Active not recruiting | Sumitomo Pharma Switzerland GmbH | 530 | 2025-04-30 | 2025-08-01 | |
| Commercial or Open Source Closed Loop Impact on Pregnancy Study Commercial AID system, Open source AID system - Type 1 Diabetes, Pregnancy, High Risk | Recruiting | University of California, San Francisco | 1000 | 2025-03-13 | 2026-07-27 | |
| Psychobiological Interventions in Pregnancy Step count goal, Actigraph watch - Pregnancy Complications, Mental Health Issue | Not applicable | Enrolling by invitation | Stanford University | 88 | 2025-01-13 | 2026-05-15 |
| SCRIPT: Sickle Cell Risk in Pregnancy Tool Non-Interventional - Sickle Cell Disease, Pregnancy, High Risk | Enrolling by invitation | Mount Sinai Hospital, Canada | 1000 | 2024-09-01 | 2024-11-27 | |
| DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes Metformin, Insulin - Gestational Diabetes Mellitus, Pregnancy, High Risk | Phase 4 | Recruiting | Ohio State University | 1572 | 2024-08-01 | 2026-10-07 |
| Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT) Ceftriaxone 1000 MG, Clarithromycin 500mg, Metronidazole 500 mg - Preterm Premature Rupture of Membrane, Pregnancy, High Risk | Phase 4 | Recruiting | Ohio State University | 56 | 2024-07-18 | 2026-01-27 |
| Successfully Achieving and Maintaining Euglycemia During Pregnancy for Type 2 Diabetes Through Technology and Coaching DEXCOM G7 PRO Continuous Glucose Monitor, Patient mHealth app linked to a provider dashboard, Care team coaching for medical and social needs (HUB) - Pre-Gestational Diabetes, Type2diabetes | Not applicable | Recruiting | Ohio State University | 124 | 2024-07-11 | 2026-06-29 |
| Remote Telemedicine Fetal Monitoring Feasibility Study Pregnabit Pro device and PregnaOne platform, Pulsenmore device - Pregnancy, High Risk, Telemonitoring | Not applicable | Completed | Birmingham Women's NHS Foundation Trust | 15 | 2024-06-20 | 2025-02-05 |
| Continuous Glucose Monitor Use in Pregnancy Continuous Glucose Monitor, Routine Capillary Blood Glucose Monitoring (Fingerstick Glucose) - Type 2 Diabetes Treated With Insulin, Pregnancy, High Risk | Not applicable | Recruiting | University of Massachusetts, Worcester | 180 | 2024-05-23 | 2026-08-03 |
| Nurse Family Partnership for Women With Previous Live Births Nurse Family Partnership - Pregnancy, High Risk, Child Development | Not applicable | Terminated | University of Colorado, Denver | 23 | 2024-04-29 | 2025-09-04 |
| Transdermal Patch for BupRenorphine Induction DurinG PrEgnancy (Patch BRIDGE) Buprenorphine Transdermal Matrix Patch, Sham patch - Opioid Use Disorder, Pregnancy Related | Phase 3 | Completed | Washington University School of Medicine | 7 | 2023-11-27 | 2026-09-10 |
| Patient Versus Provider-led Titration of Insulin for Glycemic Control in Gestational Diabetes (EMPOWER) Patient-led Insulin (intervention group), Provider-led Insulin (standard care) - Gestational Diabetes Mellitus, Pregnancy in Diabetic | Phase 4 | Completed | Ohio State University | 56 | 2023-10-19 | 2025-07-02 |
| Motor Imagery in High-Risk Pregnants Motor imagery, Diaphragmatic breathing - Pregnancy, High Risk | Not applicable | Completed | Izmir University of Economics | 76 | 2023-08-01 | 2024-01-31 |
| A Randomized Controlled Trial of Diabetes Screening Immediately Postpartum (DIP) and Follow Up PP CARE Immediate inpatient postpartum OGTT, Standard of care 4-12 week postpartum OGTT - Pre-Gestational Diabetes, Type2diabetes | Not applicable | Recruiting | Ohio State University | 104 | 2023-07-24 | 2026-09-29 |
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Pregnancy Complications (15) · Diabetes, Gestational (13) · Anxiety Disorders (7) · Diabetes Mellitus, Type 2 (7) · Pregnancy in Diabetics (6) · Premature Birth (6) · Obesity (5) · Diabetes Mellitus, Type 1 (4) · Insulin Resistance (4) · Depression (3) · Depression, Postpartum (3) · Diabetes Mellitus (3) · Hypertension, Pregnancy-Induced (3) · Opioid-Related Disorders (3) · Overweight (3)
Urogenital Diseases (38) · Female Urogenital Diseases and Pregnancy Complications (37) · Pregnancy Complications (22) · Nutritional and Metabolic Diseases (21) · Metabolic Diseases (20) · Endocrine System Diseases (19) · Glucose Metabolism Disorders (19) · Diabetes Mellitus (16) · Mental Disorders (12) · Pathological Conditions, Signs and Symptoms (10) · Body Weight (7) · Signs and Symptoms (7) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (6) · Immune System Diseases (6) · Cardiovascular Diseases (5)
Insulin (5) · Standard of Care (2) · relugolix (2) · Amoxicillin (1) · Azithromycin (1) · Blood Cell Count (1) · Ceftriaxone (1) · Cesarean Section (1) · Clarithromycin (1) · Decision Support Techniques (1) · Educational Status (1) · Enoxaparin (1) · Erythromycin (1) · Estradiol (1) · Insulin Aspart (1)
Ohio State University (8) · Indiana University (3) · The University of Texas Health Science Center, Houston (3) · University of Aarhus (3) · University of Oxford (3) · Cukurova University (2) · George Washington University (2) · IRCCS San Raffaele (2) · Sumitomo Pharma Switzerland GmbH (2) · University of Massachusetts, Worcester (2) · Albany Medical College (1) · Amasya University (1) · Birmingham Women's NHS Foundation Trust (1) · Boston Medical Center (1) · Cedars-Sinai Medical Center (1)
United States (35) · Turkey (Türkiye) (6) · United Kingdom (6) · Italy (5) · Denmark (4) · Canada (3) · Pakistan (3) · Zambia (3) · Kenya (2) · Belgium (1) · China (1) · Finland (1) · France (1) · Ghana (1) · India (1)
Kartik K Venkatesh, MD, PhD (5) · Kartik Venkatesh, MD, PhD (3) · Christine Field, MD, MPH (2) · Gianna L Wilkie, MD (2) · A. Kinga Malinowski, MD, MSc (1) · Afshan Hameed (1) · Anna Brewton, MD (1) · Anna S Koefoed, M.D. (1) · Anna S Koefoed, MD (1) · Annika Strandell, Ass.prof. (1) · Antonia Testa, PhD (1) · Antonio Lanzone, PhD (1) · Arpita Basu, PhD (1) · Ashley N Battarbee, MD (1) · Caroline Rouse, MD (1)
PMID 21268030, PMID 29898442, PMID 30826791, PMID 31250239, PMID 31578808, PMID 31731006, PMID 32312326, PMID 32748394, PMID 33262186, PMID 33693835, PMID 34082839, PMID 34250266, PMID 34389547, PMID 35031521, PMID 35349380, PMID 35503345, PMID 35503346, PMID 35594122, PMID 35751089, PMID 36360995, PMID 36839232, PMID 37019443, PMID 37054807, PMID 37103536, PMID 37141601, PMID 37164461, PMID 37429432, PMID 37859587, PMID 37868333, PMID 38072494, PMID 38258566, PMID 38423770, PMID 38954844, PMID 39317491, PMID 39809234, PMID 39840550, PMID 40544301, PMID 40717494, PMID 40720446, PMID 41237146, PMID 41624594, PMID 41712937, PMID 41842598, PMID 42586723
K23HD103875 (1), K23HD111526 (1), K23HD113845 (1), R01HD096798 (1), R01HD101476 (1), R21MD017396 (1), R34HL155481 (1)