11 completed, 2 unknown, 1 terminated. 5 Not applicable, 3 Phase 1, 3 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 3, Unknown 2 |
| Phase 1 | 3 | Completed 3 |
| Phase 2 | 3 | Completed 3 |
| Phase 4 | 1 | Terminated 1 |
Follow Prader Willi Syndrome: new trials by email Literature Review of Prader Willi Syndrome trials Research Report on Prader Willi Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Functional Connectome in Prader-Willi Syndrome: Neuroimaging and AI to Assess Therapeutic Impact GH treatment (Somatropin), Eating - Prader Willi Syndrome, Hyperphagia | Completed | Corporacion Parc Tauli | 101 | 2025-03-01 | 2025-04-01 | |
| Post Exercise Irisin Levels in PWS Patients exercise and blood tests - Prader Willi Syndrome | Not applicable | Unknown | Shaare Zedek Medical Center | 32 | 2016-04-01 | 2016-04-05 |
| Oxytocin Trial in Prader-Willi Syndrome Intranasal oxytocin, Placebo - Prader Willi Syndrome | Phase 1 | Completed | University of Florida | 24 | 2015-03-01 | 2018-04-05 |
| Prader-Willi Syndrome Macronutrient Study Low Carbohydrate diet, Low Fat diet - Prader Willi Syndrome, Syndromic Obesity | Not applicable | Completed | Duke University | 10 | 2014-05-01 | 2016-12-14 |
| Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi Syndrome Low dose (1 mcg) ACTH stimulation test, Overnight metyrapone test - Prader Willi Syndrome, Adrenal Insufficiency | Not applicable | Completed | Nationwide Children's Hospital | 23 | 2014-03-01 | 2018-01-29 |
| Hypoglycemia in Prader-Willi Syndrome Infants with Prader-Willi Syndrome - Prader Willi Syndrome, Hypoglycemia | Completed | University of Florida | 2 | 2013-07-01 | 2014-09-25 | |
| Evaluation of Tolerance, Suckling and Food Intake After Repeated Nasals Administrations of Oxytocin in PWS Infants oxytocin - Prader Willi Syndrome | Phase 1 / Phase 2 | Completed | University Hospital, Toulouse | 18 | 2013-05-01 | 2024-02-21 |
| Liraglutide Use in Prader-Willi Syndrome Liraglutide - Diabetes Mellitus Type 2, Prader Willi Syndrome | Phase 4 | Terminated | Vancouver General Hospital | 1 | 2012-02-01 | 2015-12-09 |
| Family-based Intervention for Youth With Prader-Willi Syndrome: The Active Play at Home Study Active Play at Home - Prader Willi Syndrome, Childhood Obesity | Not applicable | Unknown | California State University, Fullerton | 115 | 2011-05-01 | 2014-02-10 |
| Comparative Study Between Prader-Willi Patients Who Take Oxytocin Versus Placebo Syntocinon®/- Spray, Physiological serum (Sodium chloride) - Prader Willi Syndrome | Phase 2 | Completed | University Hospital, Toulouse | 24 | 2009-06-01 | 2017-05-12 |
| Behavioral Treatment of Obsessive-Compulsive Symptoms in Youth With Prader-Willi Syndrome: A Pilot Project Cognitive-behavioral therapy, Wait-list control - Prader Willi Syndrome, Obsessive-compulsive Disorder | Phase 1 / Phase 2 | Completed | University of South Florida | 24 | 2008-09-01 | 2011-08-08 |
| Correlation of Hyperghrelinemia With Carotid Artery Intima-Media Thickness in Children With Prader-Willi Syndrome Prader Willi Syndrome, Obesity | Completed | Samsung Medical Center | 51 | 2006-08-01 | 2007-05-17 | |
| Characterization of Transcriptional Regulators of Ghrelin Hormone Which Causes Genetic Obesity Prader Willi Syndrome, Obesity | Completed | Samsung Medical Center | 58 | 2005-01-01 | 2011-07-28 | |
| Macronutrient Regulation of Ghrelin and Peptide YY High carbohydrate meal, High fat meal - Obesity, Prader Willi Syndrome | Not applicable | Completed | Duke University | 28 | 2004-01-01 | 2015-08-10 |
Prader-Willi Syndrome (14) · Obesity (4) · Pediatric Obesity (2) · Adrenal Insufficiency (1) · Anxiety Disorders (1) · Compulsive Behavior (1) · Diabetes Mellitus, Type 2 (1) · Disease (1) · Hoarding (1) · Hyperphagia (1) · Hypoglycemia (1) · Insulin Resistance (1) · Mental Disorders (1) · Obsessive-Compulsive Disorder (1) · Social Behavior (1)
Abnormalities, Multiple (14) · Chromosome Disorders (14) · Congenital Abnormalities (14) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (14) · Genetic Diseases, Inborn (14) · Imprinting Disorders (14) · Intellectual Disability (14) · Nervous System Diseases (14) · Neurobehavioral Manifestations (14) · Neurologic Manifestations (14) · Nutrition Disorders (14) · Nutritional and Metabolic Diseases (14) · Overnutrition (14) · Overweight (14) · Obesity (10)
Oxytocin (2) · Cognitive Behavioral Therapy (1) · Diet, Carbohydrate-Restricted (1) · Diet, Fat-Restricted (1) · Eating (1) · Exercise (1) · Hematologic Tests (1) · Human Growth Hormone (1) · Liraglutide (1) · Sodium Chloride (1)
Duke University (2) · Samsung Medical Center (2) · University Hospital, Toulouse (2) · University of Florida (2) · California State University, Fullerton (1) · Corporacion Parc Tauli (1) · Nationwide Children's Hospital (1) · Shaare Zedek Medical Center (1) · University of South Florida (1) · Vancouver General Hospital (1)
United States (7) · Canada (2) · France (2) · Spain (1)
Jennifer L Miller, MD (2) · Michael Freemark, MD (2) · Andrea Haqq, MD (1) · Andrea M Haqq, MD (1) · Daniela A Rubin, Ph.D. (1) · Dong-Kyu Jin, M.D (1) · Eric Storch, Ph.D. (1) · Gross Tsur Varda, Prof. (1) · Jason Kong, MD, FRCPC (1) · Kyung Hoon Paik, M.D. (1)
PMID 21702900, PMID 24529259, PMID 26259133, PMID 28100688, PMID 28823614, PMID 30346530, PMID 30407275, PMID 30833118, PMID 33232306
K23RR021979 (1)