65 completed, 8 unknown, 6 terminated, 3 active not recruiting. 69 Not applicable, 7 Phase 2, 4 Phase 4, 3 Phase 3, 2 Early Phase 1.
Follow Diet, Carbohydrate-Restricted: new trials by email Literature Review of Diet, Carbohydrate-Restricted trials Research Report on Diet, Carbohydrate-Restricted
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Inositol and Metformin Administration in Mediterranean Diet and Low-Carbohydrate Diets in Women With PCOS Metformin, İnositol, Folic Acid - PCOS (Polycystic Ovary Syndrome), Insulin Resistance | Not applicable | Recruiting | Dicle University | 90 | 2026-08-13 | 2026-10-16 |
| Low-carbohydrate Diet and Low-Density Lipoprotein - Cholesterol (LDL-c) Interindividual Variability control diet, Low carbohydrate diet - Healthy | Not applicable | Recruiting | University of Bath | 20 | 2026-02-05 | 2026-06-30 |
| Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change Low-carbohydrate Diet, Low-fat Diet - Overweight, Obesity | Not applicable | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 42 | 2024-08-28 | 2026-10-06 |
| Metabolic Flexibility and Ketone Production During Energy Deficit Low-Carbohydrate Diet, Standard Diet With Caloric Restriction - Dietary Carbohydrate Restriction, Energy Deficit | Not applicable | Completed | Technical University of Munich | 30 | 2023-11-24 | 2026-02-24 |
| Low Carbohydrate Versus Mediterranean Diet in Adolescents With Type 1 Diabetes Low carbohydrate diet - Type 1 Diabetes | Not applicable | Unknown | Sheba Medical Center | 40 | 2023-04-19 | 2023-05-24 |
| Low-Carbohydrate and Plant-Based Dietary Effects on Vascular Health Whole-Food, Plant-Based Diet and Low-Carbohydrate Diet - Heart Disease, Ischemic, Hyperlipidemias | Not applicable | Completed | University of Rochester | 45 | 2022-12-20 | 2024-07-16 |
| Residual Insulin Secretion in Patients With Type 1 Diabetes Under a Low Carbohydrate Diet or a Ketogenic Diet Low carbohydrate diet - Type1 Diabetes | Not applicable | Completed | Assistance Publique - Hôpitaux de Paris | 30 | 2022-10-17 | 2026-07-13 |
| The Pain in Amputees Reduced by Administration of Diet Examination Low-Carbohydrate Diet - Amputation, Phantom Limb Pain | Not applicable | Completed | University of Alabama at Birmingham | 28 | 2022-07-01 | 2023-08-30 |
| Low-Carb Versus Mediterranean Diet in PCOS low-carbohydrate diet, Mediterranean diet - Polycystic Ovary Syndrome (PCOS) | Not applicable | Unknown | Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health | 130 | 2022-03-30 | 2022-04-01 |
| The Transform Type 2 Diabetes Study Total diet replacement, Low-carbohydrate diet, Intermittent fasting 5:2 - Type2diabetes | Not applicable | Unknown | Oviva UK Ltd | 120 | 2022-01-07 | 2022-12-13 |
| Westlake N-of-1 Trials for Macronutrient Intake 2 ( WE-MACNUTR 2) High fat, low carbohydrate diet, Low fat, high carbohydrate diet - Postprandial Hyperglycemia, Metabolic Disorder, Glucose | Not applicable | Completed | Westlake University | 11 | 2021-10-30 | 2022-06-01 |
| Preventing High Blood Sugar in People Being Treated for Metastatic Breast Cancer Ketogenic Diet, Low Carbohydrate Diet, Alpelisib - Breast Cancer, Breast Cancer Stage IV | Phase 2 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 15 | 2021-10-08 | 2026-08-11 |
| Isolated and Combined Effect of a Low Carbohydrate Diet and Exercise in Hypoxia in Patients With Type 2 Diabetes Exercise in normoxia, Control diet, Exercise in hypoxia - Carbohydrate, Hypoxia | Not applicable | Completed | Universidade do Porto | 42 | 2021-10-01 | 2023-07-19 |
| Low-carbohydrate Diet in Children with Type 1 Diabetes Low-carbohydrate diet, Recommended-carbohydrate diet - Type1diabetes | Not applicable | Active not recruiting | University Hospital, Motol | 35 | 2021-09-22 | 2024-12-09 |
| Effects of Different Dietary Interventions on Abdominal Fat Components, Quadriceps Muscles and Cardiometabolic Parameters Calorie restriction and balanced distribution of macronutrients, Calorie restriction and low-carbohydrate diet, Calorie restriction and low-fat diet - Abdominal Obesity, Cardiac Disease | Not applicable | Enrolling by invitation | University of Pernambuco | 100 | 2021-08-23 | 2024-10-15 |
| Metabolic Changes Induced by a Very Low Carbohydrate Diet in Youth With Type 1 Diabetes low carbohydrate diet, standard carbohydrate diet - Type1diabetes, Low Carbohydrate Diet | Not applicable | Completed | Yale University | 19 | 2021-07-29 | 2025-10-16 |
| Maximising Time With a Normal Blood Glucose to Restore the Glucagon Response in Type 1 Diabetes Stepped hyperinsulinaemic-hypoglycaemic clamp study, Insulin pump, Continuous glucose monitor - Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia | Not applicable | Completed | University of Edinburgh | 24 | 2021-07-26 | 2026-01-28 |
| REmote SUpport for Low-Carbohydrate Treatment of Type 2 Diabetes Low Carbohydrate diet - Type 2 Diabetes Mellitus in Obese | Not applicable | Completed | University of Oxford | 115 | 2021-07-01 | 2026-01-05 |
| Efficacy and Safety of Low-Carbohydrate Diet Combined With Probiotics for Weight Loss in Male Obese Patients. Low-carbohydrate diet, Probiotic compound preparations, Placebo - Obesity | Not applicable | Completed | Sun Jia | 44 | 2021-06-01 | 2024-03-13 |
| Low-Carb/Time-restricted Feeding Protocol in Insulin-Using Type 2 Diabetics Low Carbohydrate Diet, Time Restricted Feeding - Type2 Diabetes | Not applicable | Completed | University of Wisconsin, Madison | 20 | 2021-02-01 | 2022-03-14 |
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Obesity (31) · Diabetes Mellitus, Type 2 (13) · Weight Loss (12) · Insulin Resistance (11) · Diabetes Mellitus, Type 1 (10) · Diabetes Mellitus (7) · Overweight (6) · Metabolic Syndrome (5) · Cardiovascular Diseases (4) · Non-alcoholic Fatty Liver Disease (4) · Prediabetic State (4) · Breast Neoplasms (3) · Glucose Metabolism Disorders (3) · Intermittent Fasting (3) · Metabolic Diseases (3)
Helsinki University Central Hospital (4) · University of Alabama at Birmingham (4) · University of California, San Francisco (4) · Albert Einstein College of Medicine (2) · Brigham and Women's Hospital (2) · Chinese Academy of Sciences (2) · Duke University (2) · Insel Gruppe AG, University Hospital Bern (2) · Sheba Medical Center (2) · Spanish Foundation for Neurometrics Development (2) · Stanford University (2) · Assistance Publique - Hôpitaux de Paris (1) · Azienda Ospedaliero, Universitaria Pisana (1) · Baylor University (1) · Beth Israel Medical Center (1)
United States (43) · United Kingdom (6) · China (5) · Canada (4) · Finland (4) · Sweden (4) · Denmark (2) · Israel (2) · Switzerland (2) · Australia (1) · Brazil (1) · Czechia (1) · France (1) · Germany (1) · Italy (1)
Christopher D Gardner, PhD (2) · Holly Wyatt, MD (2) · James Hill, PhD (2) · Lia Bally, MD PhD (2) · Rick Hecht, MD (2) · Samuel Klein, MD (2) · Seppo Heinonen, prof (2) · Amit Algotar, MD, PhD, MPH (1) · Amy M Goss, PhD (1) · Andrea M Haqq, MD (1) · Arturo Orea, MD (1) · Barbara Gower, PhD (1) · Barbara L Peterlin, DO (1) · Benjamin Levy, M.D. (1) · Berit Johansen, PhD (1)
PMID 30924570, PMID 19366978, PMID 20019677, PMID 20082927, PMID 21679058, PMID 21820684, PMID 22036100, PMID 22045665, PMID 22052963, PMID 22152305, PMID 22316641, PMID 22723441, PMID 24312178, PMID 24435584, PMID 24717684, PMID 24790820, PMID 25029619, PMID 25178568, PMID 25527748, PMID 26803589, PMID 27035816, PMID 27152153, PMID 27430708, PMID 28841772, PMID 28915825, PMID 29456073, PMID 29467335, PMID 29601997, PMID 29735574, PMID 30545813, PMID 30672127, PMID 30865775, PMID 30944249, PMID 30964436, PMID 31338545, PMID 31467583, PMID 32108029, PMID 32186326, PMID 33522954, PMID 33769300, PMID 33819069, PMID 33852013, PMID 33855215, PMID 33855222, PMID 34101004, PMID 34375388, PMID 34560607, PMID 34656033, PMID 35020917, PMID 35037893
1DP3DK113358-01 (1), K23DK128560 (1), K24CA160653 (1), P20GM109036 (1), P30AG031054 (1), P30DK045735 (1), R01AT001103 (1), R01AT001930 (1), R01DK091831 (1), R01DK115483 (1), R21AT000525 (1), R33AT009333 (1), R61AT009333 (1), T32HL007034 (1), UL1TR000001 (1)