13 completed, 7 recruiting, 7 unknown, 4 terminated. 33 Phase 1, 8 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 33 | Completed 13, Recruiting 7, Unknown 7, Terminated 4, Not yet recruiting 1, Withdrawn 1 |
| Phase 2 | 8 | Unknown 3, Recruiting 2, Terminated 2, Completed 1 |
Follow Pleural Effusion, Malignant: new trials by email Literature Review of Pleural Effusion, Malignant trials Research Report on Pleural Effusion, Malignant
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | David Bartlett, MD | 10 | 2026-06-03 | 2026-08-04 |
| WSK-IM02 in Advanced Solid Tumors With Malignant Effusions (Phase I) WSK-IM02 - Advanced Solid Tumors, Malignant Pleural Effusions | Phase 1 | Not yet recruiting | WestVac Biopharma Co., Ltd. | 9 | 2026-06-01 | 2026-05-29 |
| Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 (IL-2) - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 10 | 2026-05-01 | 2026-04-07 |
| First-in-Human Expanded Cohort Study of Intrapleural Administration of TolueneSulfonamide in Patients With Malignant Pleural Effusion Intrapleural administration of TolueneSulfonamide, Intrapleural administration of normal saline injection - Malignant Pleural Effusions (Mpe), Non Small Cell Lung Cancer | Phase 1 / Phase 2 | Recruiting | Gang Hou | 105 | 2026-04-24 | 2026-05-15 |
| A Phase Ib Study of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion JMKX000197, Tube thoracostomy drainage - Malignant Pleural Effusions (Mpe) | Phase 1 | Recruiting | Jemincare | 30 | 2024-12-28 | 2025-04-04 |
| A Study of MT027 in Patients with Pleural Malignant Tumors MT027 cells suspension - Advanced Malignant Solid Tumor, Malignant Pleural Effusion | Phase 1 | Recruiting | Suzhou Maximum Bio-tech Co., Ltd. | 18 | 2024-05-15 | 2024-12-10 |
| Phase I Evaluation of Immunotoxin LMB-100 Administered by Normothermic, Intrapleural Perfusion Following Cytoreductive Surgery in Participants With Pleural Mesotheliomas, or Pleural Effusions From Cancers Expressing Mesothelin Cytoreductive surgery, LMB-100, Immunohistochemical Assay for Mesothelin - Malignant Pleural Mesotheliomas (Mpm), Malignant Pleural Effusions (Mpe) | Phase 1 | Withdrawn | National Cancer Institute (NCI) | 2024-01-31 | 2024-02-02 | |
| Tocilizumab Delivered Via Pleural and Peritoneal Catheters in Patients With Advanced Metastatic Cancer Tocilizumab - Malignant Pleural Effusion, Malignant Ascites | Phase 1 | Recruiting | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 12 | 2024-01-30 | 2025-05-22 |
| OPC5: Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) in Patients With Malignant Pleural Effusion. PITAC - Malignant Pleural Effusion, Pleural Neoplasms | Phase 1 | Unknown | Odense University Hospital | 20 | 2023-09-15 | 2024-05-20 |
| A Phase I Study of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion JMKX000197 - Malignant Pleural Effusion | Phase 1 | Unknown | Jemincare | 78 | 2023-05-22 | 2023-06-28 |
| IFN-γ Combined With T Cells in the Treatment of Refractory Malignant Pleural Effusion and Ascites IFN-γ and CIK cells, Tcm cells or CAR T cells - Pleural Effusion, Malignant | Phase 1 | Unknown | Affiliated Hospital of Jiangnan University | 40 | 2022-12-20 | 2024-05-16 |
| A Phase Ib/II Clinical Trial of M701 in the Treatment of Malignant Pleural Effusions Caused by NSCLC M701 pleural infusion, Pleural drainage, Cisplatin pleural infusion - Malignant Pleural Effusions, NSCLC Stage IV | Phase 1 / Phase 2 | Recruiting | Wuhan YZY Biopharma Co., Ltd. | 116 | 2022-09-30 | 2026-07-08 |
| A Study of Intrapleural Administration of Bevacizumab and Camrelizumab for Malignant Pleural Effusion bevacizumab and camrelizumab - Malignant Pleural Effusion | Phase 1 / Phase 2 | Unknown | The First Affiliated Hospital of Zhengzhou University | 55 | 2022-08-01 | 2022-04-15 |
| Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma RSO-021 - Malignant Pleural Effusion, Malignant Pleural Mesothelioma | Phase 1 / Phase 2 | Completed | RS Oncology LLC | 50 | 2022-03-31 | 2026-07-24 |
| A Phase I Study Evaluating SCB-313(Recombinant Human TRAIL-Trimer Fusion Protein) for the Treatment of Malignant Pleural Effusion SCB-313 - Malignant Pleural Effusion | Phase 1 | Completed | Sichuan Clover Biopharmaceuticals, Inc. | 14 | 2020-01-08 | 2022-05-06 |
| Study With SCB-313 (Recombinant Human TRAIL-Trimer Fusion Protein) for Treatment of Malignant Pleural Effusions SCB-313 - Malignant Pleural Effusions | Phase 1 | Completed | Clover Biopharmaceuticals AUS Pty | 5 | 2019-11-20 | 2022-02-02 |
| Comparison of the Effectiveness of Povidone-Iodine Alone to Povidone-Iodine-Tetracycline Combination CHEMICAL PLEURODESIS WITH POVIDONE-IODINE-TETRACYCLINE COMBINATION, CHEMICAL PLEURODESIS WITH POVIDONE-IODINE ALONE - Malignant Pleural Effusion | Phase 1 | Unknown | University College Hospital, Ibadan | 62 | 2019-06-20 | 2020-11-05 |
| A Study of Nivolumab and Intrapleural Talimogene Laherparepvec for Malignant Pleural Effusion Talimogene laherparepvec (TVEC), Nivolumab - Malignant Pleural Effusion, Stage IV Metastatic Cancer | Phase 1 / Phase 2 | Terminated | UNC Lineberger Comprehensive Cancer Center | 1 | 2019-03-06 | 2021-04-20 |
| A Study of Syngenon (BSG-001) for Inhalation in Subjects With Malignant Pleural Effusion and/or Malignant Ascites BSG-001 - Malignant Pleural Effusion, Malignant Ascites | Phase 1 / Phase 2 | Unknown | BioSyngen Pte Ltd | 58 | 2019-01-01 | 2018-11-08 |
| Management of Malignant Pleural Effusion With Indwelling Pleural Catheter Versus Silver Nitrate Pleurodesis Silver Nitrate, Indwelling Pleural Catheter - Pleural Effusion, Malignant | Phase 1 / Phase 2 | Unknown | Assiut University | 50 | 2019-01-01 | 2018-12-20 |
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Carcinoma, Non-Small-Cell Lung (10) · Lung Neoplasms (7) · Mesothelioma, Malignant (7) · Breast Neoplasms (5) · Neoplasm Metastasis (5) · Esophageal Neoplasms (4) · Neoplasms (4) · Anus Neoplasms (3) · Bile Duct Neoplasms (3) · Breast Neoplasms, Male (3) · Carcinoma, Hepatocellular (3) · Carcinoma, Renal Cell (3) · Colonic Neoplasms (3) · Endometrial Neoplasms (3)
Neoplasms by Site (32) · Pleural Diseases (32) · Respiratory Tract Diseases (32) · Respiratory Tract Neoplasms (32) · Thoracic Neoplasms (32) · Pleural Effusion (31) · Pleural Neoplasms (31) · Neoplasms (29) · Lung Diseases (17) · Bronchial Neoplasms (11) · Lung Neoplasms (11) · Neoplasms by Histologic Type (11) · Neoplasms, Glandular and Epithelial (11) · Adenoma (10) · Carcinoma, Bronchogenic (10)
Bevacizumab (3) · Carboplatin (3) · Interleukin-2 (2) · Pharmaceutical Preparations (2) · Trastuzumab (2) · aldesleukin (2) · Afatinib (1) · Bortezomib (1) · Cisplatin (1) · Cytoreduction Surgical Procedures (1) · Dasatinib (1) · Decitabine (1) · Docetaxel (1) · Erlotinib Hydrochloride (1) · Etoposide (1)
National Cancer Institute (NCI) (5) · Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) (2) · Jemincare (2) · Abramson Cancer Center at Penn Medicine (1) · Affiliated Hospital of Jiangnan University (1) · Assiut University (1) · BioSyngen Pte Ltd (1) · Candel Therapeutics, Inc. (1) · Centre Hospitalier Universitaire Vaudois (1) · Clover Biopharmaceuticals AUS Pty (1) · David Bartlett, MD (1) · Gang Hou (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Institut Curie (1) · M.D. Anderson Cancer Center (1)
United States (15) · China (8) · Australia (2) · Denmark (1) · France (1) · Nigeria (1) · Switzerland (1) · United Kingdom (1)
Patrick Wagner, MD (2) · Angela Davies (1) · Anthony W. Tolcher, MD (1) · Ben Creelan, M.D. (1) · Charu Aggarwal, MD (1) · Daniel H. Sterman, MD (1) · David Bartlett, MD (1) · David E. Gerber, MD (1) · David R. Jones, MD (1) · David S Schrump, M.D. (1) · David S. Schrump, MD (1) · Feng Wang (1) · Gang Hou, PhD (1) · George Blumenschein, MD (1) · Hans-Beat Ris, MD, Prof. (1)
PMID 20068553, PMID 29550074, PMID 42448681
2014 (1), N01CM17101 (1), U01CA076576 (1)