17 completed, 12 unknown, 7 terminated, 2 not yet recruiting. 42 Phase 2, 8 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 42 | Completed 17, Unknown 12, Terminated 7, Not yet recruiting 2, Recruiting 2, Active not recruiting 1, Withdrawn 1 |
| Phase 1 | 8 | Unknown 3, Recruiting 2, Terminated 2, Completed 1 |
Follow Pleural Effusion, Malignant: new trials by email Literature Review of Pleural Effusion, Malignant trials Research Report on Pleural Effusion, Malignant
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase II Study to Evaluate JMKX000197 Injection Versus Cisplatin in the Treatment of Malignant Pleural Effusion JMKX000197, Cisplatin - Malignant Pleural Effusions (Mpe) | Phase 2 | Not yet recruiting | Shanghai Jeyou Pharmaceutical Co., Ltd. | 120 | 2026-08-17 | 2026-06-16 |
| Furmonertinib Plus Radiotherapy for EGFR+ NSCLC With Pleural Effusion Furmonertinib, Thoracic Radiotherapy (TRT) - Lung Cancer (NSCLC), Malignant Pleural Effusions (Mpe)- Pleurodesis | Phase 2 | Not yet recruiting | Jiangmen Central Hospital | 63 | 2026-07-01 | 2026-07-17 |
| First-in-Human Expanded Cohort Study of Intrapleural Administration of TolueneSulfonamide in Patients With Malignant Pleural Effusion Intrapleural administration of TolueneSulfonamide, Intrapleural administration of normal saline injection - Malignant Pleural Effusions (Mpe), Non Small Cell Lung Cancer | Phase 1 / Phase 2 | Recruiting | Gang Hou | 105 | 2026-04-24 | 2026-05-15 |
| A Phase Ib/II Clinical Trial of M701 in the Treatment of Malignant Pleural Effusions Caused by NSCLC M701 pleural infusion, Pleural drainage, Cisplatin pleural infusion - Malignant Pleural Effusions, NSCLC Stage IV | Phase 1 / Phase 2 | Recruiting | Wuhan YZY Biopharma Co., Ltd. | 116 | 2022-09-30 | 2026-07-08 |
| A Study of Intrapleural Administration of Bevacizumab and Camrelizumab for Malignant Pleural Effusion bevacizumab and camrelizumab - Malignant Pleural Effusion | Phase 1 / Phase 2 | Unknown | The First Affiliated Hospital of Zhengzhou University | 55 | 2022-08-01 | 2022-04-15 |
| Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma RSO-021 - Malignant Pleural Effusion, Malignant Pleural Mesothelioma | Phase 1 / Phase 2 | Completed | RS Oncology LLC | 50 | 2022-03-31 | 2026-07-24 |
| Intrapleural Instillation of the Nivolumab in Cancer Patients With Pleural Effusion. Nivolumab - Renal Cell Cancer Metastatic, Non-small Cell Lung Cancer Metastatic | Phase 2 | Completed | Kidney Cancer Research Bureau | 26 | 2020-08-10 | 2023-03-08 |
| A Study of Nivolumab and Intrapleural Talimogene Laherparepvec for Malignant Pleural Effusion Talimogene laherparepvec (TVEC), Nivolumab - Malignant Pleural Effusion, Stage IV Metastatic Cancer | Phase 1 / Phase 2 | Terminated | UNC Lineberger Comprehensive Cancer Center | 1 | 2019-03-06 | 2021-04-20 |
| A Study of Syngenon (BSG-001) for Inhalation in Subjects With Malignant Pleural Effusion and/or Malignant Ascites BSG-001 - Malignant Pleural Effusion, Malignant Ascites | Phase 1 / Phase 2 | Unknown | BioSyngen Pte Ltd | 58 | 2019-01-01 | 2018-11-08 |
| Management of Malignant Pleural Effusion With Indwelling Pleural Catheter Versus Silver Nitrate Pleurodesis Silver Nitrate, Indwelling Pleural Catheter - Pleural Effusion, Malignant | Phase 1 / Phase 2 | Unknown | Assiut University | 50 | 2019-01-01 | 2018-12-20 |
| A Randomized Study of Primary Tumor Radiotherapy for Patients With MPE Stage IV NSCLC Radiation, Chemotherapy - Malignant Pleural Effusion, Nonsmall Cell Lung Cancer, Stage IV | Phase 2 | Unknown | Guizhou Medical University | 68 | 2018-09-01 | 2019-06-14 |
| Bevacizumab in the Treatment of Malignant Pleural Effusions of Non-squamous Non-small Cell Lung Cancer Bevacizumab - Malignant Pleural Effusion | Phase 2 | Unknown | Peking University Cancer Hospital & Institute | 87 | 2016-10-01 | 2018-11-07 |
| Intrapleural Docetaxel Administration Using Medical Pleuroscopy in Malignant Effusion With Lung Cancer intrapleural docetaxel administration - Pleural Effusion, Malignant, Non-small Cell Carcinoma | Phase 2 | Completed | Asan Medical Center | 4 | 2016-07-26 | 2019-03-08 |
| Clinical Trial of Tumor Cell-derived Microparticles Packaging Chemotherapeutic Drugs to Treat Malignant Pleural Effusion tumor derived microparticles, cisplatin - Malignant Pleural Effusion | Phase 2 | Unknown | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 90 | 2016-01-01 | 2019-02-26 |
| Recombinant Adenoviral Human p53 Gene in Treatment of Malignant Pleural Effusion rAdp53, Cisplatin, rAdp53 plus cisplatin - Malignant Pleural Effusion | Phase 2 | Unknown | Shenzhen SiBiono GeneTech Co.,Ltd | 90 | 2015-06-01 | 2015-04-29 |
| Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer metformin hydrochloride, placebo, Chemotherapy - Brenner Tumor, Malignant Ascites | Phase 2 | Completed | University of Chicago | 111 | 2015-02-25 | 2026-03-27 |
| The Effect of Non-Steroidal Anti-Inflammatory Drug Naproxen on Pleural Effusion Formation After Lung Resection Naproxen, Placebo - Pleural Effusion, Pleural Effusion Malignant | Phase 2 | Terminated | McMaster University | 7 | 2014-04-01 | 2018-02-15 |
| Intrapleural Bevacizumab Injection for Malignant Effusion in Lung Cancer Bevacizumab - Non-small Cell Lung Cancer, Malignant Pleural Effusion | Phase 2 | Completed | Haihong Yang, MD, Pricipal investigator | 22 | 2014-01-01 | 2019-03-29 |
| Safety and Effectiveness Study of Tumor Cell-derived Microparticles to Treat Malignant Ascites and Pleural Effusion Drug-packaging microparticles - Malignant Pleural Effusion,, Malignant Ascites | Phase 2 | Unknown | Huazhong University of Science and Technology | 30 | 2013-05-01 | 2013-10-01 |
| Efficacy and Safety of Bevacizumab Versus Pulvis Talci in Malignant Pleural Effusion Bevacizumab, Pulvis talci - Malignant Pleural Effusion | Phase 2 | Unknown | Tang-Du Hospital | 183 | 2012-01-01 | 2014-02-04 |
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Carcinoma, Non-Small-Cell Lung (15) · Lung Neoplasms (7) · Neoplasm Metastasis (6) · Adenocarcinoma of Lung (4) · Carcinoma, Ovarian Epithelial (3) · Fallopian Tube Neoplasms (3) · Pleural Effusion (3) · Myeloproliferative Disorder, Chronic, with Eosinophilia (2) · Ovarian Neoplasms (2) · Pericardial Effusion (2) · Small Cell Lung Carcinoma (2) · Adenocarcinoma, Bronchiolo-Alveolar (1) · Ascites (1) · Brenner Tumor (1)
Neoplasms (42) · Neoplasms by Site (42) · Pleural Diseases (42) · Pleural Neoplasms (42) · Respiratory Tract Diseases (42) · Respiratory Tract Neoplasms (42) · Thoracic Neoplasms (42) · Pleural Effusion (39) · Lung Diseases (20) · Bronchial Neoplasms (17) · Carcinoma, Bronchogenic (17) · Lung Neoplasms (14) · Neoplasms by Histologic Type (8) · Neoplasms, Glandular and Epithelial (8) · Pathological Conditions, Signs and Symptoms (8)
Carboplatin (6) · Cisplatin (6) · Bevacizumab (5) · Paclitaxel (5) · Docetaxel (4) · Drug Therapy (3) · Taxes (3) · Cetuximab (2) · Fluorodeoxyglucose F18 (2) · Gemcitabine (2) · Nivolumab (2) · Silver Nitrate (2) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · Bortezomib (1) · Dihematoporphyrin Ether (1)
National Cancer Institute (NCI) (3) · H. Lee Moffitt Cancer Center and Research Institute (2) · M.D. Anderson Cancer Center (2) · University of Washington (2) · Abramson Cancer Center at Penn Medicine (1) · Asan Medical Center (1) · Assiut University (1) · BioSyngen Pte Ltd (1) · Canadian Cancer Trials Group (1) · Cancer Trials Ireland (1) · Eli Lilly and Company (1) · Gang Hou (1) · Genzyme, a Sanofi Company (1) · Guizhou Medical University (1) · Haihong Yang, MD, Pricipal investigator (1)
United States (16) · China (11) · Canada (3) · United Kingdom (3) · Australia (1) · Brazil (1) · Germany (1) · Ireland (1) · Netherlands (1) · Russia (1) · South Korea (1) · Spain (1)
Alberto Chiappori, MD (1) · Bo Huang, Ph.D (1) · Carlos A. Jimenez, MD (1) · Diane M. Provencher, MD, FRCS, FACOG (1) · Feng Wang (1) · Gang Hou, PhD (1) · Gayle Cook, RN (1) · Gerold Bepler, MD, PhD (1) · Haihong Yang, MD (1) · Hans Hoffmann, MD, PhD (1) · Helen J. Mackay, MD (1) · Ilya Tsimafeyeu, M.D. (1)
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