10 completed, 6 recruiting, 1 active not recruiting, 1 terminated. 9 Phase 1, 4 Phase 2, 2 Early Phase 1, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 4, Recruiting 3, Active not recruiting 1, Withdrawn 1 |
| Phase 2 | 4 | Completed 4 |
| Early Phase 1 | 2 | Recruiting 2 |
| Not applicable | 1 | Completed 1 |
Follow Pineoblastoma: new trials by email Literature Review of Pineoblastoma trials Research Report on Pineoblastoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| B7-H3.CD28Z.CART in CNS Neoplasms B7-H3.CD28Z.CART, Fludarabine, Cyclophosphamide - Central Nervous System Neoplasms, Brain Tumor | Phase 1 | Recruiting | Robbie Majzner | 70 | 2026-09-01 | 2026-09-03 |
| A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. SGT-53, hypofractionated radiotherapy with immunotherapy, Nivolumab - CNS Malignancies, Medulloblastoma Recurrent | Early Phase 1 | Recruiting | Children's National Research Institute | 18 | 2025-12-16 | 2026-04-29 |
| Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation Cytarabine IT, hydrocortisone, Cisplatin - CNS Embryonal Tumor, CNS, Medulloblastoma | Early Phase 1 | Recruiting | C17 Council | 15 | 2025-09-23 | 2026-07-14 |
| GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults GPC2-CAR T cells, Fludarabine, Cyclophosphamide - Medulloblastoma, Central Nervous System Embryonal Tumor | Phase 1 | Recruiting | Stanford University | 18 | 2025-08-28 | 2026-10-09 |
| Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT) Multi-tumor antigen specific cytotoxic T lymphocytes (TSA-T) directed against proteogenomically determined personalized tumor-specific antigens (TSA), Group A Standard-of-Care Backbone Therapy, Group B Salvage Backbone Therapy - Medulloblastoma, Childhood, Atypical Teratoid/Rhabdoid Tumor of CNS | Phase 1 | Recruiting | Children's National Research Institute | 12 | 2024-09-20 | 2026-10-13 |
| Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors Anaplastic Astrocytoma, Diffuse Brainstem Glioma | Terminated | Pediatric Brain Tumor Consortium | 57 | 2023-07-12 | 2026-04-23 | |
| StrataXRT in Preventing Radiation Dermatitis in Pediatric Patients Undergoing Radiation Therapy to the Brain or Spinal Cord Placebo Administration, Questionnaire Administration, Wound Dressing Material - Central Nervous System Sarcoma, Ependymoma | Phase 1 | Withdrawn | M.D. Anderson Cancer Center | 2019-08-19 | 2024-10-09 | |
| EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors EGFR806-specific chimeric antigen receptor (CAR) T cell - Central Nervous System Tumor, Pediatric, Glioma | Phase 1 | Completed | Seattle Children's Hospital | 11 | 2019-03-19 | 2025-12-17 |
| HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors HER2-specific chimeric antigen receptor (CAR) T cell - Central Nervous System Tumor, Pediatric, Glioma | Phase 1 | Active not recruiting | Seattle Children's Hospital | 10 | 2018-07-26 | 2025-12-17 |
| SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Gemcitabine, ribociclib, sonidegib - Anaplastic Astrocytoma, Anaplastic Ependymoma | Phase 1 | Completed | St. Jude Children's Research Hospital | 68 | 2018-03-05 | 2024-05-31 |
| International PPB/DICER1 Registry Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor | Recruiting | Children's Hospitals and Clinics of Minnesota | 3400 | 2016-12-06 | 2026-10-26 | |
| Prospective Pilot Trial to Assess a Multimodal Molecular Targeted Therapy in Children, Adolescent and Young Adults With Relapsed or Refractory High-grade Pineoblastoma Temozolomide, Irinotecan, Dasatinib - Pineoblastoma | Phase 2 | Completed | University of Regensburg | 4 | 2016-04-01 | 2021-08-05 |
| Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors Adavosertib, Irinotecan Hydrochloride - Central Nervous System Embryonal Tumor With Rhabdoid Features, Central Nervous System Embryonal Tumor, Not Otherwise Specified | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 76 | 2014-03-28 | 2023-09-26 |
| Morphological Analysis of the Pineal Gland in Pediatric Retinoblastoma Patients Using Magnetic Resonance Imaging Retinoblastoma, Pineoblastoma | Completed | Charite University, Berlin, Germany | 80 | 2013-11-01 | 2015-12-29 | |
| Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Bevacizumab, Irinotecan Hydrochloride, Temozolomide - Central Nervous System Neoplasm, Pineoblastoma | Phase 2 | Completed | National Cancer Institute (NCI) | 108 | 2010-11-22 | 2021-07-23 |
| Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma proton beam radiation - Brain Tumor, Medulloblastoma | Not applicable | Completed | Massachusetts General Hospital | 90 | 2010-04-08 | 2025-08-13 |
| Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous System 3-Dimensional Conformal Radiation Therapy, Carboplatin, Cisplatin - Medulloblastoma, Pineoblastoma | Phase 1 | Completed | National Cancer Institute (NCI) | 33 | 2009-02-25 | 2022-01-13 |
| Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Pleuropulmonary Blastoma, Cystic Nephroma | Completed | Ashley Hill | 1247 | 2005-03-01 | 2023-03-01 | |
| Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors Stem Cell Transplant - Glioblastoma, Astrocytoma | Phase 2 | Completed | Ann & Robert H Lurie Children's Hospital of Chicago | 24 | 1998-03-01 | 2020-08-05 |
Pinealoma (19) · Medulloblastoma (14) · Central Nervous System Neoplasms (10) · Neuroectodermal Tumors, Primitive (10) · Rhabdoid Tumor (9) · Brain Neoplasms (8) · Ependymoma (7) · Neoplasms, Germ Cell and Embryonal (5) · Choroid Plexus Carcinoma (4) · Glioma (4) · Astrocytoma (3) · Glioblastoma (3) · Neuroblastoma (3) · Oligodendroglioma (2) · Pituitary Neoplasms (2)
Brain Diseases (19) · Central Nervous System Diseases (19) · Neoplasms by Histologic Type (19) · Neoplasms by Site (19) · Neoplasms, Glandular and Epithelial (19) · Neoplasms, Nerve Tissue (19) · Nervous System Diseases (19) · Nervous System Neoplasms (19) · Neuroectodermal Tumors (19) · Neoplasms (18) · Neoplasms, Neuroepithelial (18) · Neoplasms, Germ Cell and Embryonal (14) · Brain Neoplasms (11) · Neoplasms, Complex and Mixed (11) · Glioma (10)
Cyclophosphamide (4) · Irinotecan (3) · Temozolomide (3) · Automobiles (2) · Carboplatin (2) · Cisplatin (2) · Filgrastim (2) · Granulocyte Colony-Stimulating Factor (2) · Isotretinoin (2) · Thiotepa (2) · Vincristine (2) · etoposide phosphate (2) · fludarabine (2) · 1,2-diaminocyclohexaneplatinum II citrate (1) · Bandages (1)
National Cancer Institute (NCI) (3) · Children's National Research Institute (2) · Seattle Children's Hospital (2) · Ann & Robert H Lurie Children's Hospital of Chicago (1) · Ashley Hill (1) · C17 Council (1) · Charite University, Berlin, Germany (1) · Children's Hospitals and Clinics of Minnesota (1) · M.D. Anderson Cancer Center (1) · Massachusetts General Hospital (1) · Pediatric Brain Tumor Consortium (1) · Robbie Majzner (1) · St. Jude Children's Research Hospital (1) · Stanford University (1) · University of Regensburg (1)
United States (16) · Canada (4) · Germany (2) · Australia (1) · New Zealand (1) · Puerto Rico (1)
Adam S Levy (1) · Alexandra Miller, MD, PhD (1) · Annie Huang (1) · Brian Rood, MD (1) · D. Ashley Hill, MD (1) · Giles W. Robinson, MD (1) · Juliane Gust, MD, PhD (1) · Katherine Ryan, DO (1) · Kris Ann P Schultz, MD (1) · Kris Ann Schultz, MD (1) · Kristina A Cole (1) · Lucie Lafay-Cousin (1) · Rebecca Ronsley, MD (1) · Sarah E Leary (1) · Stewart Goldman, MD (1)
PMID 19556464, PMID 25209242, PMID 29343557, PMID 24481001, PMID 24761742, PMID 24821309, PMID 24909177, PMID 25118636, PMID 25356068, PMID 26555935, PMID 26671110, PMID 26925222, PMID 27441995, PMID 28323992, PMID 28674120, PMID 28748527, PMID 29037807, PMID 30118397, PMID 30178239, PMID 30339877, PMID 30672147, PMID 30677214, PMID 30715996, PMID 30824630, PMID 31296931, PMID 31820118, PMID 31838154, PMID 31952842, PMID 32291395, PMID 32415267, PMID 33119505, PMID 33484847, PMID 33570641, PMID 33630087, PMID 33637876, PMID 33782093, PMID 33875804, PMID 34253928, PMID 37640679
UM1CA081457 (2), P01CA021239 (1), U01CA081457 (1), U10CA098543 (1), U10CA180886 (1), UM1CA097452 (1)