96 completed, 25 unknown, 12 terminated, 9 recruiting. 60 Phase 2, 38 Phase 1, 27 Phase 3, 18 Not applicable, 18 Phase 4.
Follow Isotretinoin: new trials by email Literature Review of Isotretinoin trials Research Report on Isotretinoin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Itraconazole With Itraconazole and Isotretinoin in the Treatment Duration, Safety a n d Cure Rate in Adult Patients of Tinea Corporis/ Cruris-A Randomised Controlled Trail Itraconazole (200 mg), ISOtretinoin 20 MG - Tinea Corporis | Phase 4 | Not yet recruiting | Pak Emirates Military Hospital | 60 | 2026-10-01 | 2026-06-30 |
| Isotretinoin vs. Doxycycline for Acneiform Rash in Patients Receiving Drugs That Target the MAPK Pathway Isotretinoin, Doxycycline, Blood specimen collection - Acneiform Drug Eruption, Acneiform Eruptions | Phase 2 | Not yet recruiting | University of California, San Francisco | 50 | 2026-08-30 | 2026-06-05 |
| Low-Dose Versus Conventional-Dose Oral Isotretinoin for Acne Vulgaris Isotretinoin - Acne Vulgaris | Phase 4 | Not yet recruiting | Pakistan Institute of Medical Sciences | 164 | 2026-07-01 | 2026-06-10 |
| Isotretinoin vs hCG for Male Infertility Due to Low or Absent Sperm isotretinoin, Human chorionic gonadotrophin (hCG) - Oligospermia, Azoospermia, Nonobstructive | Phase 2 | Enrolling by invitation | University of Nebraska | 100 | 2026-04-13 | 2026-04-20 |
| Facial Skin Microbiome in Patients With Moderate-to-Severe Acne Vulgaris Treated With Isotretinoin ISOtretinoin 10 MG - Acne Vulgaris | Recruiting | Can Tho University of Medicine and Pharmacy | 90 | 2026-01-13 | 2026-10-01 | |
| Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation Cytarabine IT, hydrocortisone, Cisplatin - CNS Embryonal Tumor, CNS, Medulloblastoma | Early Phase 1 | Recruiting | C17 Council | 15 | 2025-09-23 | 2026-07-14 |
| Effect of Systemic Retinoic Acid Use on Micro Ribonucleic Acid (mRNA) Expression Saliva, serum sampling, oral isotretinoin - Periodontal Diseases, Inflammation | Not applicable | Not yet recruiting | Medipol University | 25 | 2025-09-01 | 2025-08-26 |
| Effects of Isotretinoin on Smell isotretinoin - Smell Dysfunction | Not applicable | Completed | Uşak University | 54 | 2025-06-01 | 2026-07-13 |
| Clinical Trial to Compare Oral Isotretinoin to Standard of Care in Moderate Acne Skin of Color Patients ISOtretinoin 5 MG, Topical cream - Acne Vulgaris | Phase 3 | Recruiting | Centre Hospitalier Universitaire de Nice | 420 | 2025-04-29 | 2026-10-01 |
| 13-cis Retinoic Acid (Isotretinoin) and Sperm Production Isotretinoin, Control group (placebo) - Men with Infertility | Phase 4 | Not yet recruiting | University Hospital, Strasbourg, France | 100 | 2025-03-01 | 2024-11-25 |
| Weekly Isotretinoin vs Tetracycline for Moderate Acne Isotretinoin, Tetracycline - Acne Vulgaris | Early Phase 1 | Recruiting | Medical University of South Carolina | 50 | 2025-02-01 | 2026-05-18 |
| Comparison of Combination of Itraconazole and Isotretinoin Versus Itraconazole Alone in the Treatment of Resistant Trichophyton Infection Itraconazole + Isotretinoin, Itraconazole (ITZ) - Dermatophytosis, Trichophyton Infection | Not applicable | Completed | Multan Medical And Dental College | 148 | 2025-01-29 | 2026-02-19 |
| Assessment of Serum Catestatin Level in Acne Vulgaris Patients Isotretinoin - Acne Vulgaris | Not applicable | Recruiting | Aswan University | 60 | 2025-01-10 | 2025-07-08 |
| Isotretinoin Versus Excimer Light an Adjuvant in Treating Onychomycosis ISOtretinoin 10 MG, excimer light, Itraconazole 200 mg - Onychomycosis | Phase 1 | Recruiting | Zagazig University | 36 | 2024-07-12 | 2026-04-23 |
| Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Ganglioneuroblastoma, Nodular, Neuroblastoma | Phase 3 | Recruiting | National Cancer Institute (NCI) | 478 | 2024-04-19 | 2026-10-30 |
| Systemic Isotretinoin Therapy and Eye Isotretinoin (13-cis-retinoic acid) - Dry Eye, Choroidal Thickness | Not applicable | Completed | Demet Mutlu | 60 | 2024-04-01 | 2026-06-30 |
| Treatment of Plane Warts With Topical and Oral Retinoids Topical tretinoin 0.05%, Topical tretinoin 0.05% + oral isotretinoin (0.5 mg/kg/day) - Plane Warts | Phase 4 | Completed | Latakia University | 39 | 2024-02-12 | 2025-06-10 |
| Correlation Between Depression Scores and Serum NF-ĸB/NLRP3 Axis, Biotinidase, and HMGB After Treatment With Isotretinoin in Patients With Acne Vulgaris ISOtretinoin 20 MG - Acne Vulgaris | Phase 3 | Completed | Mostafa Bahaa | 40 | 2024-01-30 | 2025-03-04 |
| Effect of Oral Isotretinoin on Ocular Surface and Meibomian Glands isotretinoin - Dry Eye Disease (DED), Meibomian Gland Dysfunction (Disorder) | Not applicable | Completed | Benha University | 60 | 2024-01-01 | 2026-09-10 |
| Naxitamab and Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) Combined With Isotretinoin for Maintenance Treatment of Patients With High-Risk Neuroblastoma in First Complete Response. Naxitamab - Neuroblastoma | Phase 4 | Not yet recruiting | SciClone Pharmaceuticals | 62 | 2023-10-31 | 2023-09-21 |
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Neuroblastoma (44) · Acne Vulgaris (29) · Ganglioneuroblastoma (5) · Brain Neoplasms (4) · Glioblastoma (4) · Leukemia, Myelomonocytic, Juvenile (4) · Lung Neoplasms (4) · Medulloblastoma (4) · Astrocytoma (3) · COVID-19 (3) · Carcinoma, Non-Small-Cell Lung (3) · Carcinoma, Renal Cell (3) · Central Nervous System Neoplasms (3) · Glioma (3) · Gliosarcoma (3)
National Cancer Institute (NCI) (13) · Children's Oncology Group (11) · Memorial Sloan Kettering Cancer Center (8) · M.D. Anderson Cancer Center (6) · Dr. Reddy's Laboratories Limited (4) · Eastern Cooperative Oncology Group (4) · Kafrelsheikh University (4) · Federal University of São Paulo (3) · St. Jude Children's Research Hospital (3) · University of Washington (3) · Aswan University (2) · German Society for Pediatric Oncology and Hematology GPOH gGmbH (2) · Masonic Cancer Center, University of Minnesota (2) · Medical University of South Carolina (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2)
United States (84) · Canada (17) · Australia (12) · Egypt (12) · Puerto Rico (9) · Turkey (Türkiye) (9) · United Kingdom (7) · New Zealand (6) · France (5) · Germany (5) · Switzerland (5) · Brazil (4) · China (4) · Israel (3) · Italy (3)
Brian Kushner, MD (4) · Dr. Ralph Scallion, MD (3) · Nai-Kong V. Cheung, MD, PhD (3) · Edileia Bagatin, MD, PhD (2) · Frank Berthold, MD (2) · Marta Penas-Prado, MD (2) · Robert S. DiPaola, MD (2) · Sara M Federico (2) · Sarah E Leary (2) · Wayne L Furman, MD (2) · Adam Donne (1) · Alan J Lerner, MD (1) · Alex Richmond, MD, MSCR (1) · Alice L Yu (1) · Ami V Desai (1)
PMID 23633099, PMID 34028986, PMID 10951254, PMID 11493098, PMID 15337804, PMID 15961764, PMID 16575387, PMID 19401528, PMID 20567002, PMID 20729242, PMID 20879881, PMID 21328522, PMID 22010014, PMID 22742881, PMID 23890779, PMID 24068130, PMID 24419114, PMID 24934963, PMID 25239666, PMID 27297276, PMID 27465021, PMID 29036256, PMID 30332335, PMID 30444686, PMID 31080813, PMID 31163231, PMID 31386611, PMID 31454045, PMID 32038751, PMID 32221013, PMID 32530765, PMID 3287161, PMID 33919763, PMID 34292305, PMID 34871104, PMID 35839426, PMID 36103158, PMID 37170057, PMID 37864393, PMID 37883734, PMID 37944074, PMID 39445512, PMID 39826827, PMID 40036726, PMID 40067131, PMID 7955470, PMID 8380496, PMID 8382035, PMID 8609271, PMID 8884148
U10CA098543 (8), U10CA180886 (8), P01CA081403 (2), P30CA016672 (2), P30CA072720 (2), 2009 (1), K24HD082231 (1), N01CM62204 (1), P01CA075606 (1), P30CA008748 (1), P30CA013330 (1), P30CA033572 (1), R01CA114567 (1), R01GM124264 (1), U01CA062505 (1)