4 completed, 3 recruiting, 1 active not recruiting, 1 withdrawn. 9 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 4, Recruiting 3, Active not recruiting 1, Withdrawn 1 |
| Phase 2 | 1 | Completed 1 |
Follow Pineoblastoma: new trials by email Literature Review of Pineoblastoma trials Research Report on Pineoblastoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| B7-H3.CD28Z.CART in CNS Neoplasms B7-H3.CD28Z.CART, Fludarabine, Cyclophosphamide - Central Nervous System Neoplasms, Brain Tumor | Phase 1 | Recruiting | Robbie Majzner | 70 | 2026-09-01 | 2026-09-03 |
| GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults GPC2-CAR T cells, Fludarabine, Cyclophosphamide - Medulloblastoma, Central Nervous System Embryonal Tumor | Phase 1 | Recruiting | Stanford University | 18 | 2025-08-28 | 2026-10-09 |
| Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT) Multi-tumor antigen specific cytotoxic T lymphocytes (TSA-T) directed against proteogenomically determined personalized tumor-specific antigens (TSA), Group A Standard-of-Care Backbone Therapy, Group B Salvage Backbone Therapy - Medulloblastoma, Childhood, Atypical Teratoid/Rhabdoid Tumor of CNS | Phase 1 | Recruiting | Children's National Research Institute | 12 | 2024-09-20 | 2026-10-13 |
| StrataXRT in Preventing Radiation Dermatitis in Pediatric Patients Undergoing Radiation Therapy to the Brain or Spinal Cord Placebo Administration, Questionnaire Administration, Wound Dressing Material - Central Nervous System Sarcoma, Ependymoma | Phase 1 | Withdrawn | M.D. Anderson Cancer Center | 2019-08-19 | 2024-10-09 | |
| EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors EGFR806-specific chimeric antigen receptor (CAR) T cell - Central Nervous System Tumor, Pediatric, Glioma | Phase 1 | Completed | Seattle Children's Hospital | 11 | 2019-03-19 | 2025-12-17 |
| HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors HER2-specific chimeric antigen receptor (CAR) T cell - Central Nervous System Tumor, Pediatric, Glioma | Phase 1 | Active not recruiting | Seattle Children's Hospital | 10 | 2018-07-26 | 2025-12-17 |
| SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Gemcitabine, ribociclib, sonidegib - Anaplastic Astrocytoma, Anaplastic Ependymoma | Phase 1 | Completed | St. Jude Children's Research Hospital | 68 | 2018-03-05 | 2024-05-31 |
| Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors Adavosertib, Irinotecan Hydrochloride - Central Nervous System Embryonal Tumor With Rhabdoid Features, Central Nervous System Embryonal Tumor, Not Otherwise Specified | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 76 | 2014-03-28 | 2023-09-26 |
| Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous System 3-Dimensional Conformal Radiation Therapy, Carboplatin, Cisplatin - Medulloblastoma, Pineoblastoma | Phase 1 | Completed | National Cancer Institute (NCI) | 33 | 2009-02-25 | 2022-01-13 |
Medulloblastoma (9) · Pinealoma (9) · Neuroectodermal Tumors, Primitive (7) · Central Nervous System Neoplasms (6) · Ependymoma (6) · Rhabdoid Tumor (6) · Brain Neoplasms (5) · Glioma (4) · Choroid Plexus Carcinoma (3) · Neoplasms, Germ Cell and Embryonal (3) · Astrocytoma (1) · Glioblastoma (1) · Lymphoma, Follicular (1) · Meningeal Neoplasms (1) · Meningioma (1)
Brain Diseases (9) · Central Nervous System Diseases (9) · Neoplasms by Histologic Type (9) · Neoplasms by Site (9) · Neoplasms, Glandular and Epithelial (9) · Neoplasms, Nerve Tissue (9) · Nervous System Diseases (9) · Nervous System Neoplasms (9) · Neuroectodermal Tumors (9) · Neoplasms (8) · Neoplasms, Neuroepithelial (8) · Neoplasms, Complex and Mixed (6) · Neoplasms, Germ Cell and Embryonal (6) · Glioma (5) · Brain Neoplasms (4)
Cyclophosphamide (3) · Automobiles (2) · fludarabine (2) · 1,2-diaminocyclohexaneplatinum II citrate (1) · Bandages (1) · Carboplatin (1) · Cisplatin (1) · Filgrastim (1) · Gemcitabine (1) · Granulocyte Colony-Stimulating Factor (1) · Irinotecan (1) · Isotretinoin (1) · Peripheral Blood Stem Cell Transplantation (1) · Platinum (1) · Radiotherapy, Conformal (1)
National Cancer Institute (NCI) (2) · Seattle Children's Hospital (2) · Children's National Research Institute (1) · M.D. Anderson Cancer Center (1) · Robbie Majzner (1) · St. Jude Children's Research Hospital (1) · Stanford University (1)
United States (9) · Canada (1)
Brian Rood, MD (1) · Giles W. Robinson, MD (1) · Juliane Gust, MD, PhD (1) · Katherine Ryan, DO (1) · Kristina A Cole (1) · Rebecca Ronsley, MD (1) · Sarah E Leary (1) · Susan Chi (1) · Susan L McGovern (1)
U01CA081457 (1), UM1CA081457 (1), UM1CA097452 (1)