38 completed, 11 recruiting, 7 terminated, 4 withdrawn. 32 Phase 1, 13 Phase 2, 6 Not applicable, 3 Early Phase 1, 2 Phase 3.
Follow Pinealoma: new trials by email Literature Review of Pinealoma trials Research Report on Pinealoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors NEO100 - Pediatric Tumor of CNS, Pediatric Tumor of Brain | Phase 1 | Recruiting | Neonc Technologies, Inc. | 12 | 2026-09-08 | 2026-09-15 |
| B7-H3.CD28Z.CART in CNS Neoplasms B7-H3.CD28Z.CART, Fludarabine, Cyclophosphamide - Central Nervous System Neoplasms, Brain Tumor | Phase 1 | Recruiting | Robbie Majzner | 70 | 2026-09-01 | 2026-09-03 |
| A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. SGT-53, hypofractionated radiotherapy with immunotherapy, Nivolumab - CNS Malignancies, Medulloblastoma Recurrent | Early Phase 1 | Recruiting | Children's National Research Institute | 18 | 2025-12-16 | 2026-04-29 |
| Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation Cytarabine IT, hydrocortisone, Cisplatin - CNS Embryonal Tumor, CNS, Medulloblastoma | Early Phase 1 | Recruiting | C17 Council | 15 | 2025-09-23 | 2026-07-14 |
| GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults GPC2-CAR T cells, Fludarabine, Cyclophosphamide - Medulloblastoma, Central Nervous System Embryonal Tumor | Phase 1 | Recruiting | Stanford University | 18 | 2025-08-28 | 2026-10-09 |
| Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT) Multi-tumor antigen specific cytotoxic T lymphocytes (TSA-T) directed against proteogenomically determined personalized tumor-specific antigens (TSA), Group A Standard-of-Care Backbone Therapy, Group B Salvage Backbone Therapy - Medulloblastoma, Childhood, Atypical Teratoid/Rhabdoid Tumor of CNS | Phase 1 | Recruiting | Children's National Research Institute | 12 | 2024-09-20 | 2026-10-13 |
| The Evolution of Neuroendoscopy Guided by Head-mounted Mixed Reality Technique Navigation System in Neurosurgery Conventinal Navigation System Group - Pineal Tumor, Brainstem Tumor | Not applicable | Not yet recruiting | Shanghai Zhongshan Hospital | 40 | 2024-07-01 | 2024-07-24 |
| Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors Anaplastic Astrocytoma, Diffuse Brainstem Glioma | Terminated | Pediatric Brain Tumor Consortium | 57 | 2023-07-12 | 2026-04-23 | |
| Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification Observational - Glioma, Glioneuronal Tumor | Recruiting | European Organisation for Research and Treatment of Cancer - EORTC | 1650 | 2023-03-21 | 2025-12-17 | |
| Fluorescence Detection of Adult Primary Central Nervous System Tumors With Tozuleristide and the Canvas System tozuleristide, Canvas imaging system, Surgical resection of tumor - Central Nervous System Tumor | Phase 2 | Completed | John Yu | 50 | 2021-09-30 | 2026-07-10 |
| Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms ONC206 - Central Nervous System Neoplasms, Glioblastoma | Phase 1 | Recruiting | Jazz Pharmaceuticals | 102 | 2020-10-26 | 2025-12-18 |
| Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors SCRI-CARB7H3(s); B7H3-specific chimeric antigen receptor (CAR) T cel - Central Nervous System Tumor, Diffuse Intrinsic Pontine Glioma | Phase 1 | Recruiting | Seattle Children's Hospital | 90 | 2019-12-11 | 2026-04-13 |
| StrataXRT in Preventing Radiation Dermatitis in Pediatric Patients Undergoing Radiation Therapy to the Brain or Spinal Cord Placebo Administration, Questionnaire Administration, Wound Dressing Material - Central Nervous System Sarcoma, Ependymoma | Phase 1 | Withdrawn | M.D. Anderson Cancer Center | 2019-08-19 | 2024-10-09 | |
| EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors EGFR806-specific chimeric antigen receptor (CAR) T cell - Central Nervous System Tumor, Pediatric, Glioma | Phase 1 | Completed | Seattle Children's Hospital | 11 | 2019-03-19 | 2025-12-17 |
| HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors HER2-specific chimeric antigen receptor (CAR) T cell - Central Nervous System Tumor, Pediatric, Glioma | Phase 1 | Active not recruiting | Seattle Children's Hospital | 10 | 2018-07-26 | 2025-12-17 |
| SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Gemcitabine, ribociclib, sonidegib - Anaplastic Astrocytoma, Anaplastic Ependymoma | Phase 1 | Completed | St. Jude Children's Research Hospital | 68 | 2018-03-05 | 2024-05-31 |
| Immune Checkpoint Inhibitor Nivolumab in People With Recurrent Select Rare CNS Cancers Nivolumab, EKG, MRI Brain and/or spine - Medulloblastoma, Ependymoma | Phase 2 | Terminated | National Cancer Institute (NCI) | 136 | 2017-07-13 | 2026-08-18 |
| Melatonin Replacement Therapy in Pinealectomized Patients Melatonin Replacement Therapy - Pineal Tumor | Early Phase 1 | Completed | University of Sao Paulo | 5 | 2017-05-02 | 2019-03-21 |
| Entinostat in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors Entinostat, Laboratory Biomarker Analysis, Pharmacological Study - Brain Stem Neoplasm, Pineal Region Neoplasm | Phase 1 | Completed | National Cancer Institute (NCI) | 21 | 2017-01-06 | 2023-10-17 |
| International PPB/DICER1 Registry Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor | Recruiting | Children's Hospitals and Clinics of Minnesota | 3400 | 2016-12-06 | 2025-01-30 |
Showing 20 of 66. Sign in to see all of them.
Medulloblastoma (51) · Brain Neoplasms (42) · Ependymoma (41) · Glioma (40) · Neuroectodermal Tumors, Primitive (38) · Astrocytoma (37) · Central Nervous System Neoplasms (35) · Oligodendroglioma (34) · Meningioma (31) · Glioblastoma (30) · Choroid Plexus Neoplasms (27) · Gliosarcoma (26) · Craniopharyngioma (24) · Glioma, Subependymal (19)
Brain Diseases (66) · Central Nervous System Diseases (66) · Neoplasms by Histologic Type (66) · Neoplasms by Site (66) · Neoplasms, Glandular and Epithelial (66) · Neoplasms, Nerve Tissue (66) · Nervous System Diseases (66) · Nervous System Neoplasms (66) · Neuroectodermal Tumors (65) · Neoplasms, Neuroepithelial (62) · Neoplasms (57) · Neoplasms, Germ Cell and Embryonal (56) · Neoplasms, Vascular Tissue (32) · Central Nervous System Neoplasms (31) · Meningeal Neoplasms (30)
Temozolomide (7) · Cyclophosphamide (5) · Carboplatin (4) · Irinotecan (4) · Magnetic Resonance Spectroscopy (4) · Automobiles (3) · Filgrastim (3) · Surgical Procedures, Operative (3) · Thiotepa (3) · etoposide phosphate (3) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (2) · Amplified Fragment Length Polymorphism Analysis (2) · Bevacizumab (2) · Celecoxib (2) · Cisplatin (2)
National Cancer Institute (NCI) (11) · Wake Forest University Health Sciences (4) · National Institutes of Health Clinical Center (CC) (3) · Seattle Children's Hospital (3) · Case Comprehensive Cancer Center (2) · Children's National Research Institute (2) · City of Hope Medical Center (2) · Abramson Cancer Center at Penn Medicine (1) · Ann & Robert H Lurie Children's Hospital of Chicago (1) · Ashley Hill (1) · C17 Council (1) · Cancer Research UK (1) · Charite University, Berlin, Germany (1) · Children's Hospitals and Clinics of Minnesota (1) · Children's Oncology Group (1)
United States (53) · Canada (4) · Germany (4) · Australia (2) · France (2) · Switzerland (2) · United Kingdom (2) · Austria (1) · Belgium (1) · Brazil (1) · Greece (1) · Italy (1) · Netherlands (1) · New Zealand (1) · Norway (1)
Darell D. Bigner, MD, PhD (2) · Jana Portnow, MD (2) · Rebecca Ronsley, MD (2) · Adam S Levy (1) · Alexandra Miller, MD, PhD (1) · Andrea O. Rossetti, MD (1) · Andrew Bukowinski (1) · Annie Huang (1) · Antonio Omuro (1) · Brian G. Fuller (1) · Brian Rood, MD (1) · D. Ashley Hill, MD (1) · Dennis D Hickstein, M.D. (1) · Edward A. Neuwelt, MD (1) · Edward G. Shaw, MD (1)
PMID 19556464, PMID 25209242, PMID 29343557, PMID 11410496, PMID 16549835, PMID 18470481, PMID 21850464, PMID 22480131, PMID 23388559, PMID 24481001, PMID 24761742, PMID 24821309, PMID 24909177, PMID 25118636, PMID 25356068, PMID 26555935, PMID 26671110, PMID 26925222, PMID 27020837, PMID 27441995, PMID 28323992, PMID 28674120, PMID 28748527, PMID 29037807, PMID 30118397, PMID 30178239, PMID 30339877, PMID 30672147, PMID 30677214, PMID 30715996, PMID 30824630, PMID 31296931, PMID 31820118, PMID 31838154, PMID 31952842, PMID 32291395, PMID 32415267, PMID 32431667, PMID 33119505, PMID 33484847, PMID 33570641, PMID 33630087, PMID 33637876, PMID 33782093, PMID 33875804, PMID 34253928, PMID 35417530, PMID 35468680, PMID 37640679, PMID 39775044
P30CA033572 (2), U10CA081851 (2), UM1CA081457 (2), UM1CA097452 (2), N01CM62202 (1), P01CA021239 (1), P30CA008748 (1), P30CA014089 (1), P30CA016087 (1), P30CA016672 (1), P30CA043703 (1), P30CA069533 (1), P30CA086862 (1), P30CA124435 (1), U01CA069856 (1)