5 completed, 2 recruiting, 1 terminated, 1 unknown. 3 Phase 1, 2 Phase 2, 1 Early Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Completed 2, Recruiting 1 |
| Phase 2 | 2 | Completed 1, Recruiting 1 |
| Early Phase 1 | 1 | Recruiting 1 |
| Phase 3 | 1 | Terminated 1 |
Follow C17 Council: new trials by email
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation Cytarabine IT, hydrocortisone, Cisplatin - CNS Embryonal Tumor, CNS, Medulloblastoma | Early Phase 1 | Recruiting | C17 Council | 15 | 2025-09-23 | 2026-07-14 |
| Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer Paxalisib, Opdualag, Irinotecan (drug) - Childhood Cancer, Childhood Solid Tumor | Phase 1 / Phase 2 | Recruiting | Australian & New Zealand Children's Haematology/Oncology Group | 90 | 2024-07-10 | 2026-01-28 |
| Phase I Dose Escalation Study of Topotecan and Pazopanib in Children With Recurrent/Refractory Solid Tumours Topotecan and Pazopanib - Solid Tumors | Phase 1 / Phase 2 | Completed | The Hospital for Sick Children | 30 | 2015-03-01 | 2022-06-28 |
| N-PhenoGENICS: Neurocognitive-Phenome, Genome, Epigenome and Nutriome In Childhood Leukemia Survivors Childhood Leukemia Survivors | Completed | The Hospital for Sick Children | 204 | 2013-07-01 | 2020-10-08 | |
| Phase I Dose Finding Study for Melatonin in Pediatric Oncology Patients With Relapsed Solid Tumors Melatonin - Relapsed Malignant Solid Tumor | Phase 1 | Completed | C17 Council | 9 | 2013-05-01 | 2019-01-31 |
| Preventing Cardiac Sequelae in Pediatric Cancer Survivors Anthracycline-induced Cardiotoxicity | Completed | The Hospital for Sick Children | 1128 | 2012-12-01 | 2019-07-08 | |
| Pharmacological Predictors of Successful Cyclosporine Acute GVHD Prophylaxis in Children Undergoing HSCT Acute-graft-versus-host Disease | Completed | Lee Dupuis | 105 | 2010-10-01 | 2021-08-19 | |
| Low Dose Versus Usual Dose Dexamethasone for Symptom Control in Children Undergoing Cranial or Craniospinal Radiation High dose dexamethasone, Low dose dexamethasone - Vomiting, Headache | Phase 3 | Terminated | The Hospital for Sick Children | 25 | 2010-06-01 | 2016-05-05 |
| Osteonecrosis in Children With Acute Lymphoblastic Leukemia Osteonecrosis, Acute Lymphoblastic Leukemia | Unknown | Halton, Jacqueline, M.D. | 130 | 2009-07-01 | 2010-04-15 |
Precursor Cell Lymphoblastic Leukemia-Lymphoma (2) · Central Nervous System Neoplasms (1) · Headache (1) · Leukemia (1) · Lymphoma (1) · Medulloblastoma (1) · Neoplasms (1) · Neuroblastoma (1) · Neuroectodermal Tumors, Primitive (1) · Neurotoxicity Syndromes (1) · Osteonecrosis (1) · Pinealoma (1) · Pyloric Stenosis, Hypertrophic (1) · Recurrence (1) · Rhabdoid Tumor (1)
Temozolomide (2) · Carboplatin (1) · Celecoxib (1) · Cisplatin (1) · Cyclophosphamide (1) · Dexamethasone (1) · Etoposide (1) · Filgrastim (1) · Granulocyte Colony-Stimulating Factor (1) · Hydrocortisone (1) · Irinotecan (1) · Isotretinoin (1) · Melatonin (1) · Mesna (1) · Opdualag (1)
Canada (9) · Australia (1) · United States (1)
Annie Huang (1) · Daniel Morgenstern, Dr (1) · David Ziegler, Prof (1) · Donna Johnston, MD (1) · Dr. Brenda Spiegler (1) · Dr. Deborah L O'Connor (1) · Dr. Johann Hitzler (1) · Dr. Rosanna Weksberg (1) · Dr. Russell Schachar (1) · Dr. Sharon Guger (1) · Dr. Shinya Ito, MD (1) · Jacqueline Halton (1) · Jim Whitlock (1) · Lee Dupuis, PhD (1) · Luc Mertens, M.D. (1)