54 completed, 27 unknown, 4 recruiting, 2 not yet recruiting. 73 Not applicable, 3 Phase 1, 2 Early Phase 1, 2 Phase 2, 2 Phase 3.
Follow Orthodontic Appliance Complication: new trials by email Literature Review of Orthodontic Appliance Complication trials Research Report on Orthodontic Appliance Complication
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bacterial Diversity Study Using 16S rRNA Sequencing of Periodontal Samples From Patients With Orthodontic Retainers Fixed Orthodontic Retainer, Removable Essix-Type Orthodontic Retainer - Fixed Orthodontic Retainer, Orthodontic Appliances, Removable | Not applicable | Recruiting | Universidad de Murcia | 10 | 2026-01-12 | 2026-07-28 |
| Comparison of a 3-step Bonding System (Transbond™ XT) and a 2-step System (GC Ortho Connect™) on Demineralization Around Maxillary Orthodontic Brackets Transbond™ XT bonding procedure, GC Ortho Connect™ bonding procedure - Tooth Demineralization, White Spot Lesion | Not applicable | Not yet recruiting | University Hospital, Montpellier | 34 | 2026-01-01 | 2026-01-21 |
| Cotinus Coggygria Mouthwash and Halitosis and Oral Hygiene in Orthodontic Patients Cotinus Coggygria mouthwash, Placebo mouthwash - Orthodontic Appliance Complication, Halitosis | Not applicable | Completed | University of Athens | 30 | 2025-12-03 | 2025-12-18 |
| Evaluation of Maxillary Buccal Miniscrew Insertion Using Digital Guides CAD/CAM 3D-Printed Surgical Guide, Free-Hand Orthodontic Miniscrew Placement - Orthodontic Appliance Complication | Not applicable | Completed | Can Tho University of Medicine and Pharmacy | 33 | 2025-11-01 | 2026-07-13 |
| Microbial Adherence, Surface Roughness, Effectiveness and Impact on Patients Between Conventional and 3D Printed Twin Block Appliances Conventional TBA, 3D TBA - Orthodontic Appliances, Removable, Orthodontic Appliance Complication | Not applicable | Recruiting | University of Malaya | 32 | 2025-05-01 | 2025-06-18 |
| Effect of Clear Aligner Attachment Size on Extrusion of Maxillary Lateral Incisors Corresponding treatment order in the prescription with Align Technology, Superimposition of final and initial positions of lateral incisors: Predicted model, Superimposition of final and initial positions of lateral incisors: Gingivally beveled 1x1x3mm aligners - Orthodontic Appliance Complication | Not applicable | Completed | Virginia Commonwealth University | 28 | 2025-03-31 | 2026-06-08 |
| Chios Mastic Toothpaste and Halitosis and Oral Hygiene in Orthodontic Patients mastic toothpaste, Placebo toothpaste - Halitosis, Orthodontic Appliance Complication | Not applicable | Not yet recruiting | University of Athens | 30 | 2025-01-07 | 2025-01-09 |
| Effect of Local Subperiosteal Zoledronic Acid Injection on the Survival of Orthodontic Miniscrews Zoledronic Acid, Normal saline (0.9% sodium chloride) - Orthodontic Appliance Complication | Not applicable | Completed | Latakia University | 68 | 2024-12-01 | 2026-04-22 |
| The Effect of Intraoral Transcutaneous Electrical Nerve Stimulation in Orthodontics Pain Active TENS Device, Intervention 2: Placebo/Sham Device - Orthodontic Appliance, Pain | Not applicable | Recruiting | University of the Pacific | 150 | 2024-09-16 | 2026-02-17 |
| Evaluation of Taste Sensation Changes During Fixed Orthodontic Treatment Taste Test - Taste Disorders, Orthodontic Appliance Complication | Not applicable | Completed | Biruni University | 128 | 2024-09-01 | 2025-05-25 |
| Derma Pen as Treatment of Gingivitis Induced by Orthodontics mechanical periodontal treatment, Derma pen with topical ascorbic Acid - Gingivitis, Orthodontic Appliance Complication | Not applicable | Completed | Safa Basiouny Alawy | 24 | 2024-05-30 | 2025-05-13 |
| Assessment of Pain When Removing Metallic Brackets for Orthodontic Patients Using Two Removal Methods Bracket removal using a Weingart plier with the mouth open, Biting on a cotton roll during brakcet removal - Orthodontic Appliance Complication | Not applicable | Completed | Damascus University | 36 | 2024-05-19 | 2025-03-12 |
| Evaluation of The Stability of Orthodontic Treatment After First Premolar Extraction Using Combined Retention Protocol combined protocol of retention (bonded lingual retainer and vacuum formed retainers), Bonded lingual retainer - Orthodontic Appliance Complication | Not applicable | Unknown | Cairo University | 24 | 2024-03-10 | 2024-07-16 |
| Evaluation Of Anchorage Control Using Arch Wire Stopper Versus Mini-Screws archwire stopper mesial to the maxillary first molar group, inter-radicular mini-screw - Orthodontic Appliance Complication | Not applicable | Completed | Cairo University | 26 | 2024-02-13 | 2026-10-20 |
| Fluoride Delivery to Prevent White Spots During Orthodontic Treatment Fluoride mouthwash (0.05%; 225ppm)., Tooth Mousse Plus - Orthodontic Appliance Complication, Tooth Demineralization | Phase 4 | Unknown | Liverpool University Hospitals NHS Foundation Trust | 130 | 2023-10-20 | 2023-11-08 |
| Regular Home Use of Dual-light Photodynamic Therapy on Oral Health in Adolescents Undergoing Fixed Orthodontic Treatment Lumoral Treatment, Standard oral health instructions - Orthodontic Appliance Complication, Plaque, Dental | Not applicable | Completed | Koite Health Oy | 40 | 2023-09-05 | 2026-01-21 |
| Orthodontic Treatment Impact on Life Experience of Adolescents With Fixed Orthodontic Appliances appliance type - Orthodontic Appliance Complication | Completed | Cairo University | 364 | 2023-08-01 | 2024-07-24 | |
| Efficiency of Rigid Versus Non-rigid Indirect Anchorage During Canine Retraction: A Split Mouth Randomized Study non rigid indirect anchorage connection, rigid indirect anchorage connection - Orthodontic Appliance Complication | Not applicable | Completed | Cairo University | 15 | 2023-07-02 | 2024-08-15 |
| Alteration of Taste Among Orthodontic Patients Following Clear Aligners Treatment clear aligners - Taste Perception, Orthodontic Appliance Complication | Unknown | Riyadh Elm University | 134 | 2023-07-01 | 2023-11-09 | |
| Comparison of MI Paste Plus and Resin Infiltration in White Spot Lesions Following Orthodontic Treatment Resin infiltration, Casein Phosphopeptide (CPP) - Amorphous Calcium Phosphate (ACP) - Fluoride - White Spot Lesions, Orthodontic Appliance Complication | Not applicable | Recruiting | University of Alberta | 62 | 2023-05-30 | 2026-06-30 |
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Gingivitis (6) · Malocclusion (6) · Dental Caries (4) · Dental Plaque (4) · Halitosis (4) · Pain (4) · Inflammation (2) · Malocclusion, Angle Class II (2) · Tooth Demineralization (2) · Agnosia (1) · Feeding Behavior (1) · Feeding and Eating Disorders (1) · Gingival Diseases (1) · Gingival Overgrowth (1) · Heart Arrest (1)
Stomatognathic Diseases (23) · Pathological Conditions, Signs and Symptoms (16) · Tooth Diseases (15) · Signs and Symptoms (11) · Mouth Diseases (9) · Gingival Diseases (7) · Neurologic Manifestations (7) · Periodontal Diseases (7) · Infections (6) · Pathologic Processes (5) · Signs and Symptoms, Digestive (5) · Dental Deposits (4) · Tooth Demineralization (4) · Nervous System Diseases (3) · Behavior (2)
Low-Level Light Therapy (3) · Probiotics (3) · Sodium Fluoride (2) · casein phosphopeptide-amorphous calcium phosphate nanocomplex (2) · 1-phenyl-3,3-dimethyltriazene (1) · Acid Etching, Dental (1) · Biofilms (1) · Congresses as Topic (1) · Control Groups (1) · Dental Debonding (1) · Denture, Partial, Fixed, Resin-Bonded (1) · Diphosphonates (1) · Lasers (1) · Lasers, Semiconductor (1) · Motivational Interviewing (1)
Cairo University (11) · Damascus University (6) · University of Baghdad (6) · University of Malaya (5) · University of Athens (3) · King Abdulaziz University (2) · University Hospital, Montpellier (2) · University of Erlangen-Nürnberg (2) · University of Nove de Julho (2) · Al-Azhar University (1) · Ammar Alubaydi (1) · Ammar Kasem Alzoubi (1) · Armed Forces Institute of Dentistry, Pakistan (1) · Bezmialem Vakif University (1) · Biruni University (1)
Egypt (12) · Iraq (7) · Syria (7) · Malaysia (5) · Pakistan (5) · Greece (4) · Spain (4) · Turkey (Türkiye) (4) · United Kingdom (4) · Brazil (3) · Italy (3) · France (2) · Germany (2) · Saudi Arabia (2) · United States (2)
Mohammad Y Hajeer, DDS MSc PhD (4) · Iosif Sifakakis, Associate Professor (3) · Corinna Lesley Seidel, Dr. (2) · Kinda Sultan, DDS MSc PhD (2) · Abdulmalek MR Majanni, DDS MSc (1) · Ahmad Rami Dirie, DDS MSc (1) · Akram F. Alhuwaizi, Prof. (1) · Amer M Owayda, DDS (1) · Ammar S Alubaydi, MSc (1) · Amr R Elbialy, professor (1) · Andrea Noviello (1) · Andrea Scribante, DDS, PhD. (1) · Andrew Demian, BDS (1) · Aneela Nausheen, FCPS (1)
PMID 29926944, PMID 35477563, PMID 11808763, PMID 11853236, PMID 12209001, PMID 12598550, PMID 14076341, PMID 14738126, PMID 15528910, PMID 15650072, PMID 16448279, PMID 16637733, PMID 16934115, PMID 17443571, PMID 17608932, PMID 17634723, PMID 17713338, PMID 17716083, PMID 17958078, PMID 17977295, PMID 18204252, PMID 18304239, PMID 18331943, PMID 18362316, PMID 18435723, PMID 19639091, PMID 19739205, PMID 19887683, PMID 20090328, PMID 20091655, PMID 20152674, PMID 20383545, PMID 20505049, PMID 21083623, PMID 21536209, PMID 22356705, PMID 22488208, PMID 23158136, PMID 23273358, PMID 23279918, PMID 23311659, PMID 23805818, PMID 23910199, PMID 23989837, PMID 24789647, PMID 25192157, PMID 25653800, PMID 25992985, PMID 26063554, PMID 26229382