13 completed, 5 recruiting, 5 unknown, 4 terminated. 11 Phase 2, 3 Not applicable, 3 Phase 1, 2 Phase 3, 1 Phase 4.
Follow Oral Leukoplakia: new trials by email Literature Review of Oral Leukoplakia trials Research Report on Oral Leukoplakia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions 5-Amino Levulinic Acid - Oral Cancer, Oral Cavity Cancer | Phase 2 | Not yet recruiting | University of Massachusetts, Boston | 65 | 2026-09-01 | 2026-03-19 |
| Comparison of Topical Photodynamic Therapy With Topical Calcipotriol in Management of Oral Leukoplakia Non-invasive Photo Dynamic Therapy using LED of wavelength ranging from 630-660nm( Fluence 15 J/cm2) as light source and 2.5% TB as photosensitizer, Topical application of Calcipotriol ointment 0.005% twice a day for 4 weeks along with preventive and conventional therapy, Conventional non-invasive management : All subjects in the two groups will receive the same standard conventional non- invasive management advised for OL as per current scientific evidence - Oral Leukoplakia | Phase 3 | Not yet recruiting | Dr. Shalini Gupta | 166 | 2026-04-01 | 2026-03-06 |
| Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia Metformin Hydrochloride, Placebo - Oral Leukoplakia | Phase 2 | Recruiting | Cairo University | 34 | 2026-02-01 | 2026-02-06 |
| Evaluation of Artificial Intelligence in Diagnosis and Risk Assessment of Oral Potentially Malignant Disorders Toluidine blue staining of the lesion and cytological smears - Oral Lichen Planus, Oral Leukoplakia | Not yet recruiting | Ain Shams University | 120 | 2025-12-16 | 2026-01-06 | |
| Efficacy of Topical Coenzyme Q10 and Curcumin for Oral Leukoplakia Treatment Coenzyme Q10 gel, Topical curcumin gel - Oral Leukoplakia | Not applicable | Recruiting | Alexandria University | 34 | 2025-11-25 | 2026-01-12 |
| Fenretinide Mucoadhesive Patch: Evaluation of Oral Cancer Prevention Efficacy in Adults With Premalignant Oral Lesions. Mucoadhesive fenretinide-releasing system (FMS) - Oral Leukoplakia, Oral Dysplasia | Phase 1 | Completed | Ohio State University Comprehensive Cancer Center | 7 | 2025-10-14 | 2026-09-25 |
| Topical Calcipotriol Versus Photodynamic Therapy in the Treatment of Oral Leukoplakia Calcipotriol 0.005% gel, ALA mediated PDT - Oral Leukoplakia | Phase 2 / Phase 3 | Active not recruiting | Alexandria University | 30 | 2025-07-16 | 2026-06-22 |
| Pioglitazone-Metformin Combination Treatment for High Risk Oral Preneoplasia pioglitazone-metformin - Oral Leukoplakia | Phase 2 | Recruiting | University of Minnesota | 36 | 2025-01-01 | 2026-07-29 |
| Unveiling the Protein Expression Patterns in Oral Lichen Planus and Leukoplakia Through Comparative Salivary Proteomics Saliva, Oral Lichen Planus | Completed | Kocaeli University | 21 | 2024-12-25 | 2026-02-18 | |
| SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomography OCT (Optical Coherence Tomography) - Oral Squamous Cell Carcinoma, Oral Potentially Malignant Disorder | Recruiting | University of Palermo | 200 | 2024-03-13 | 2025-05-23 | |
| Analyzing Handprint Patterns to Predict Oral Cancer Risks: A Comparative Study Oral Leukoplakia | Unknown | King Khalid University | 160 | 2024-02-29 | 2024-02-21 | |
| Identification of Oral Lesions Through an Autofluorescence System Screening examination - Oral Leukoplakia, Autofluorescence | Not applicable | Completed | Federico II University | 200 | 2023-06-01 | 2026-09-02 |
| Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia Biopsy, Biospecimen Collection, Extended Release Metformin Hydrochloride - Erythroplakia, Oral Leukoplakia | Phase 2 | Active not recruiting | University of Arizona | 34 | 2023-01-12 | 2026-09-28 |
| Intralesional 5-fluorouracil Injection for the Treatment of Oral Leukoplakia 5-fluorouracil - Oral Leukoplakia | Phase 1 | Withdrawn | University of California, San Francisco | 2022-09-30 | 2022-09-22 | |
| Oral Cancer Screening and Education in Hong Kong No intervention utilised - Oral Cancer, Oral Leukoplakia | Unknown | The University of Hong Kong | 3190 | 2021-08-01 | 2020-07-27 | |
| Diagnostic Accuracy of Salivary Gamma-synuclein in Oral Malignant and Premalignant Lesions Salivary Gamma-synuclein, Incisional biopsy, Conventional visual and tactile examination - Oral Cancer, Oral Lichen Planus | Unknown | Cairo University | 69 | 2021-03-10 | 2021-02-01 | |
| Saliva and Plasma Exosomes for Oral Leukoplakia Malignant Transformation Diagnosis and Oral Cancer Prognosis Monitoring Detect the expression level of miR-185 in salivary and plasma exosomes. - Oral Leukoplakia, Oral Cancer | Completed | Beijing Stomatological Hospital, Capital Medical University | 225 | 2020-06-13 | 2024-06-24 | |
| Intra and Extra Oral Inspection of Oral Mucosa questionnaire survey - Oral Lichen Planus, Oral Leukoplakia | Terminated | Dalarna County Council, Sweden | 70 | 2020-02-01 | 2023-02-16 | |
| Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia topical melatonin, PLACEBO - Oral Leukoplakia | Not applicable | Unknown | Postgraduate Institute of Dental Sciences Rohtak | 66 | 2020-02-01 | 2020-02-05 |
| Prediction of Malignant Transformation of Oral Leukoplakia Using a MAGE-A-based Immunoscore Oral Leukoplakia, Oral Leukoplakia of Tongue | Recruiting | University of Erlangen-Nürnberg Medical School | 500 | 2019-12-01 | 2019-12-03 |
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Leukoplakia, Oral (34) · Mouth Neoplasms (12) · Lichen Planus, Oral (11) · Erythroplasia (3) · Mouth Diseases (3) · Squamous Cell Carcinoma of Head and Neck (3) · Leukoplakia (2) · Lichen Planus (2) · Oral Submucous Fibrosis (2) · Actinic cheilitis (1) · Carcinoma in Situ (1) · Carcinoma, Squamous Cell (1) · Disease (1) · Graft vs Host Disease (1) · Head and Neck Neoplasms (1)
Neoplasms (34) · Neoplasms by Site (34) · Pathological Conditions, Anatomical (34) · Pathological Conditions, Signs and Symptoms (34) · Head and Neck Neoplasms (33) · Precancerous Conditions (33) · Stomatognathic Diseases (33) · Leukoplakia (32) · Mouth Diseases (31) · Mouth Neoplasms (22) · Lichenoid Eruptions (12) · Skin Diseases (12) · Skin Diseases, Papulosquamous (12) · Skin and Connective Tissue Diseases (12) · Lichen Planus (10)
Metformin (3) · Aminolevulinic Acid (2) · Biopsy (2) · Photochemotherapy (2) · Pioglitazone (2) · 1-phenyl-3,3-dimethyltriazene (1) · Behavior Therapy (1) · Catechin (1) · Ethanol (1) · Fluconazole (1) · Fluorouracil (1) · Gels (1) · Melatonin (1) · Photosensitizing Agents (1) · Rosiglitazone (1)
National Cancer Institute (NCI) (7) · Cairo University (3) · Alexandria University (2) · National Taiwan University Hospital (2) · Ain Shams University (1) · All India Institute of Medical Sciences (1) · Beijing Stomatological Hospital, Capital Medical University (1) · Dalarna County Council, Sweden (1) · Dr. Shalini Gupta (1) · Federico II University (1) · King Khalid University (1) · Kocaeli University (1) · Ohio State University Comprehensive Cancer Center (1) · Postgraduate Institute of Dental Sciences Rohtak (1) · The Oxford Dental College, Hospital and Research Center, Bangalore, India (1)
United States (12) · Egypt (4) · India (4) · Canada (3) · Italy (3) · Taiwan (2) · China (1) · Germany (1) · Sweden (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Frank Ondrey (2) · Scott M Lippman (2) · Chun-Pin Chiang, DMSc (1) · Eglal M Moussa, PhD oral medicine (1) · Eva Szabo, M.D. (1) · Falk Wehrhan, MD, DMD (1) · Frank Meyskens (1) · Jay Boyle (1) · Jonathan Celli, PhD (1) · Jutta Ries, PhD (1) · Karin Gunnars Hellgren (1) · Kyle Jones, DDS, PhD (1) · Manuel Weber, MD, DMD (1) · Mohammad Akram, MD (1)
PMID 39532605, PMID 39584361, PMID 14520092, PMID 23639862, PMID 33813637, PMID 34255745
N01CN35159 (2), P30CA016672 (2), P30CA023074 (2), N01CN00031 (1), N01CN35153 (1), P30CA008748 (1), P30CA060553 (1), R01CA227273 (1), U01CA072294 (1), U01CA279862 (1), UG1CA242596 (1)